First Trust Exchange-Traded Fund VI
First Trust Nasdaq Bank ETF (FTXO) 

First Trust Nasdaq Food & Beverage ETF (FTXG) 

First Trust Nasdaq Oil & Gas ETF (FTXN) 

First Trust Nasdaq Pharmaceuticals ETF (FTXH) 

First Trust Nasdaq Retail ETF (FTXD) 

First Trust Nasdaq Semiconductor ETF (FTXL) 

First Trust Nasdaq Transportation ETF (FTXR) 

First Trust Indxx Medical Devices ETF (MDEV) 

Semi-Annual Report
For the Period Ended
September 30, 2021

 

 

Table of Contents
First Trust Exchange-Traded Fund VI
Semi-Annual Report
September 30, 2021

2

3
Fund Performance Overview

4

6

8

10

12

14

16

18

20

21
Portfolio of Investments

23

24

25

26

27

28

29

31

34

36

38

42

50

58

Table of Contents
Caution Regarding Forward-Looking Statements
This report contains certain forward-looking statements within the meaning of the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended. Forward-looking statements include statements regarding the goals, beliefs, plans or current expectations of First Trust Advisors L.P. (“First Trust” or the “Advisor”) and its representatives, taking into account the information currently available to them. Forward-looking statements include all statements that do not relate solely to current or historical fact. For example, forward-looking statements include the use of words such as “anticipate,” “estimate,” “intend,” “expect,” “believe,” “plan,” “may,” “should,” “would” or other words that convey uncertainty of future events or outcomes.
Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of any series of First Trust Exchange-Traded Fund VI (the “Trust”) described in this report (each such series is referred to as a “Fund” and collectively, the “Funds”) to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. When evaluating the information included in this report, you are cautioned not to place undue reliance on these forward-looking statements, which reflect the judgment of the Advisor and its representatives only as of the date hereof. We undertake no obligation to publicly revise or update these forward-looking statements to reflect events and circumstances that arise after the date hereof.
Performance and Risk Disclosure
There is no assurance that any Fund described in this report will achieve its investment objective. Each Fund is subject to market risk, which is the possibility that the market values of securities owned by the Fund will decline and that the value of the Fund’s shares may therefore be less than what you paid for them. Accordingly, you can lose money by investing in a Fund. See “Risk Considerations” in the Additional Information section of this report for a discussion of certain other risks of investing in the Funds.
Performance data quoted represents past performance, which is no guarantee of future results, and current performance may be lower or higher than the figures shown. For the most recent month-end performance figures, please visit www.ftportfolios.com or speak with your financial advisor. Investment returns, net asset value and share price will fluctuate and Fund shares, when sold, may be worth more or less than their original cost.
The Advisor may also periodically provide additional information on Fund performance on each Fund’s web page at www.ftportfolios.com.
How to Read This Report
This report contains information that may help you evaluate your investment. It includes details about each Fund and presents data and analysis that provide insight into each Fund’s performance and investment approach.
By reading the market overview by Robert F. Carey, Chief Market Strategist of the Advisor, you may obtain an understanding of how the market environment affected the performance of each Fund. The statistical information that follows may help you understand each Fund’s performance compared to that of relevant market benchmarks.
It is important to keep in mind that the opinions expressed by personnel of the Advisor are just that: informed opinions. They should not be considered to be promises or advice. The opinions, like the statistics, cover the period through the date on the cover of this report. The material risks of investing in each Fund are spelled out in the prospectus, the statement of additional information, and other Fund regulatory filings.
Page 1

Table of Contents
Shareholder Letter
First Trust Exchange-Traded Fund VI
Semi-Annual Letter from the Chairman and CEO
September 30, 2021
Dear Shareholders,
First Trust is pleased to provide you with the semi-annual report for certain series of the First Trust Exchange-Traded Fund VI (the “Funds”), which contains detailed information about the Funds for the six months ended September 30, 2021. Please note that the First Trust Indxx Medical Devices ETF was incepted on June 22, 2021, and so the information in this letter and the semi-annual report prior to that date will not apply to this Fund.
A great deal has changed over the past 18 months. Suffice it to say that the dominant story in 2020 was the onset of the coronavirus (“COVID-19”) pandemic. It is still a huge story 20 months later, mostly due to the arrival of the Delta variant in the U.S. and the subsequent surge in cases around mid-2021. The Delta variant is twice as contagious as the previous variants, according to the Centers for Disease Control and Prevention (“CDC”). Fortunately, we have come to learn that the existing vaccines approved by the U.S. Food and Drug Administration have been effective in providing protection against the Delta variant, particularly with respect to keeping the people already vaccinated out of the intensive care unit. As I’m sure you are aware, a significant percentage of the U.S. population has chosen not to be vaccinated. These individuals have proven to be much more vulnerable to the virus and account for the lion’s share of hospitalizations, according to the CDC. While it is these individuals right to choose, unless mandated by a private company or government agency, the universe of people that have not gotten vaccinated is large enough that it has likely delayed the full economic recovery, at least on the margin, in our opinion. In the U.S., the path chosen by the federal government to help mitigate the economic fallout from the pandemic has been to inject trillions of dollars of liquidity (stimulus) into the financial system. To date, it appears to have been effective, however, it has contributed to a new and potentially ominous headwind for the economy: inflation.
The Consumer Price Index came in at 5.4% year-over-year in September 2021, the largest increase since 2008, according to data from the Bureau of Labor Statistics (“BLS”). The BLS also reported that the Producer Price Index was up 8.6% compared to a year ago, its highest level since 1981. These two barometers of inflation are clearly elevated. Why is rising inflation worth noting? It tends to reduce the purchasing power of the currency one uses over time. In the case of the U.S., it reduces how much consumers can buy with their dollars. A modest amount of inflation can be a sign that the economy is healthy. Too much inflation can derail an economy. While we are not even close to that point yet, investors should monitor the direction of inflation moving forward because the U.S. economy has yet to fully reopen from the COVID-19 pandemic and millions of workers remain on the sideline. Earlier this year, Federal Reserve Chairman Jerome Powell proclaimed that the spike in inflation in the U.S. would be relatively short-lived, or “transitory.” He cited the pandemic-related bottlenecks in the global supply chain for creating shortages in such critical industries as semiconductors as being largely responsible for the sharp rise in prices. With prices rising nearly across the board, his take on inflation is losing credibility with each passing month, in my opinion. If inflation continues to run hotter-than-expected, we believe that the Federal Reserve will likely have to alter its easy monetary policy in favor of one that boosts interest rates and bond yields.
The markets have performed quite well over the past 18 months. I believe that the combination of the federal government’s efforts in fast-tracking the vaccines, its decisiveness in injecting trillions of dollars of capital into the financial system to help backstop it, and the ability of millions of workers to adapt to working efficiently from home helped boost the confidence levels of investors throughout. Having said that, I still feel we need to fully reopen the U.S. economy, put the millions of people out of work back to work and remedy the global supply chain bottlenecks. While investors should be prepared for the possibility of some additional volatility moving forward, due to inflationary pressures, the potential for higher interest rates and bond yields, and next year’s mid-term election season, we encourage them to stay the course.
Thank you for giving First Trust the opportunity to play a role in your financial future. We value our relationship with you and will report on the Funds again in six months.
Sincerely,
James A. Bowen
Chairman of the Board of Trustees
Chief Executive Officer of First Trust Advisors L.P.
Page 2

Table of Contents
Market Overview
First Trust Exchange-Traded Fund VI
Semi-Annual Report
September 30, 2021
Robert F. Carey, CFA
Senior Vice President and Chief Market Strategist
First Trust Advisors L.P.
Mr. Carey is responsible for the overall management of research and analysis of the First Trust product line. Mr. Carey has more than 30 years of experience as an Equity and Fixed-Income Analyst and is a recipient of the Chartered Financial Analyst (“CFA”) designation. He is a graduate of the University of Illinois at Champaign-Urbana with a B.S. in Physics. He is also a member of the Investment Analysts Society of Chicago and the CFA Institute. Mr. Carey has appeared as a guest on such programs as Bloomberg TV, CNBC, and WBBM Radio, and has been quoted by several publications, including The Wall Street Journal, The Wall Street Reporter, Bloomberg News Service, and Registered Rep.
State of the Global Economy
The International Monetary Fund (“IMF”) reported in its latest release that global gross domestic product (“GDP”) growth is expected to come in at 5.9% in 2021 and 4.9% in 2022, up from -3.1% in 2020. Keep in mind that the onset of the coronavirus (“COVID-19”) pandemic in the U.S. and most global regions occurred in the first quarter of 2020. The IMF sees the U.S. economy growing at 6.0% in 2021 and 5.2% in 2022, up from -3.4% in 2020. With respect to all Advanced Economies, the IMF is projecting GDP growth of 5.2% in 2021 and 4.5% in 2022, up from -4.5% in 2020. Lastly, the IMF projects Emerging Market and Developing Economies to grow at a rate of 6.4% in 2021 and 5.1% in 2022, up from -2.1% in 2020. Looking ahead to 2022, the outlook for growth is encouraging, but down a bit from the strong pandemic-induced recovery in 2021. The IMF is concerned that inflationary pressures stemming from the global supply chain bottlenecks could push prices higher if the problems persist. That scenario could, in turn, cause central banks to raise rates quickly to try and prevent inflation from overheating.
One of the better barometers for judging the overall business climate is mergers and acquisitions (“M&A”) activity, in our opinion. M&A deals totaled $4.3 trillion over the first nine months of 2021, the most ever recorded for that period, according to data from Refinitiv. The $1.52 trillion in deal value registered in the third quarter of 2021 was the highest ever for a calendar quarter. Executives are expanding their businesses aggressively in the current climate.
Performance of Global Stocks and Bonds
With respect to U.S. equities, the S&P 500®, S&P MidCap 400®, and S&P SmallCap 600® Indices posted total returns of 9.18%, 1.81% and 1.54%, respectively, for the six-month period ended September 30, 2021. Large-capitalization (“cap”) stocks significantly outperformed their mid- and small-cap counterparts in the period. Investors may have favored well-capitalized companies in the period due to the surge in the volume of Delta variant cases of COVID-19, in our opinion. All 11 sectors that comprise the S&P 500® Index were up on a total return basis. The top performer was the Real Estate sector, up 14.08%, while the worst result came from the Industrials sector, up 0.06%.
A Bloomberg survey of 21 equity strategists found that their average 2021 year-end price target for the S&P 500® Index was 4,466 as of September 21, 2021, up from 4,335 on August 20, 2021, according to its own release. The highest and lowest estimates were 4,825 (up from 4,700) and 3,800 (unchanged), respectively. On September 30, 2021, the S&P 500® Index closed at 4,307.54, which was 5.06% below its all-time closing high of 4,536.95 on September 2, 2021. As of October 1, 2021, Bloomberg’s 2021, 2022 and 2023 consensus earnings growth rate estimates for the S&P  500® Index stood at 44.90%, 8.95% and 9.80%, respectively.
Over the past six months, the MSCI World ex USA and MSCI Emerging Markets Indices posted total returns of 4.95% (USD) and -3.45% (USD), respectively, according to Bloomberg. The Bloomberg Global Aggregate Index of higher quality debt posted a total return of 0.42% (USD), while the Bloomberg EM Hard Currency Aggregate Index of emerging markets debt rose by 1.99% (USD), according Bloomberg. Over that same period, the U.S. dollar rose by 1.07% against a basket of major currencies, as measured by the U.S. Dollar Index (DXY). The modest increase in the dollar had little impact on the performance of these foreign indices, in our opinion.
In the U.S. bond market, the top-performing major debt group we track was high yield corporate bonds. The Bloomberg U.S. Corporate High Yield Index posted a total return of 3.65% for the six-month period ended September 30, 2021. The worst-performing U.S. debt group that we track was long maturity Government National Mortgage Association (“GNMAs”). The Bloomberg GNMA 30-Year Index posted a total return of -0.02%. The yield on the benchmark 10-Year Treasury Note (“T-Note”) increased by 25 points in the period to close at 1.49% on September 30, 2021, according to Bloomberg. For comparative purposes, the average yield on the 10-Year T-Note was 2.04% for the 10-year period ended September 30, 2021.
Page 3

Table of Contents
Fund Performance Overview (Unaudited)
First Trust Nasdaq Bank ETF (FTXO)
The First Trust Nasdaq Bank ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Banks IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXO.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the banking sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the banking sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes companies providing a broad range of financial services, including retail banking, loans and money transmissions.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV 5.63% 96.57% 12.76% 12.82%   82.32% 83.41%
Market Price 5.73% 96.80% 12.69% 12.84%   81.71% 83.52%
Index Performance              
Nasdaq US Smart Banks IndexTM 6.01% 98.23% 13.54% 13.60%   88.68% 89.85%
NASDAQ US Benchmark Banks Index 8.51% 85.58% 15.95% 15.78%   109.55% 108.93%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Banks IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 4

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Bank ETF (FTXO) (Continued)
Sector Allocation % of Total
Investments
Financials 100.0%
Total 100.0%
Top Ten Holdings % of Total
Investments
New York Community Bancorp, Inc. 8.0%
PNC Financial Services Group (The), Inc. 8.0
JPMorgan Chase & Co. 8.0
Popular, Inc. 8.0
Citigroup, Inc. 7.6
Fifth Third Bancorp 4.3
Citizens Financial Group, Inc. 4.2
Zions Bancorp N.A. 4.2
Wells Fargo & Co. 4.0
First Horizon Corp. 3.9
Total 60.2%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 5

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Food & Beverage ETF (FTXG)
The First Trust Nasdaq Food & Beverage ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Food & Beverage IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXG.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the food and beverage sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the beverages sector or food producers sector according to the Industry Classification Benchmark (“ICB”). The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) manufacturers and shippers of cider or malt products; (ii) producers, distillers, vintners, blenders and shippers of wine and spirits; (iii) manufacturers, bottlers and distributors of non-alcoholic beverages; (iv) companies that grow crops or raise livestock, operate fisheries or own non-tobacco plantations; (v) food producers, including meatpacking, snacks, fruits, vegetables, dairy products and frozen seafood; (vi) producers of pet food; and (vii) manufacturers of dietary supplements, vitamins and related items.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV -5.23% 16.50% 5.10% 5.30%   28.22% 29.64%
Market Price -6.62% 16.05% 5.08% 5.30%   28.09% 29.63%
Index Performance              
Nasdaq US Smart Food & Beverage IndexTM -4.97% 17.28% 5.77% 5.98%   32.38% 33.88%
NASDAQ US Benchmark Food, Beverage and Tobacco Index 0.03% 14.16% 7.33% 7.62%   42.45% 44.69%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Food & Beverage IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 6

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Food & Beverage ETF (FTXG) (Continued)
Sector Allocation % of Total
Investments
Consumer Staples 95.1%
Materials 3.9
Consumer Discretionary 1.0
Total 100.0%
Top Ten Holdings % of Total
Investments
Bunge Ltd. 8.8%
Tyson Foods, Inc., Class A 8.2
Archer-Daniels-Midland Co. 8.1
Darling Ingredients, Inc. 7.9
Hershey (The) Co. 7.8
General Mills, Inc. 4.2
Conagra Brands, Inc. 4.2
Kellogg Co. 4.1
B&G Foods, Inc. 4.0
JM Smucker (The) Co. 4.0
Total 61.3%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 7

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Oil & Gas ETF (FTXN)
The First Trust Nasdaq Oil & Gas ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Oil & Gas IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXN.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the oil and gas sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the oil & gas producers sector or the oil equipment, services & distribution sector according to the Industry Classification Benchmark (“ICB”). The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) companies engaged in the exploration for and drilling, production, refining and supply of oil and gas products; (ii) integrated oil and gas companies engaged in the exploration for, and drilling, production, refining, distribution and retail sales of, oil and gas products; (iii) suppliers of equipment and services to oil fields and offshore platforms, such as drilling, exploration, seismic-information services and platform construction; and (iv) operators of pipelines carrying oil, gas or other forms of fuel.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV 23.47% 106.17% -0.06% 1.02%   -0.31% 5.22%
Market Price 23.46% 106.50% -0.06% 1.03%   -0.30% 5.28%
Index Performance              
Nasdaq US Smart Oil & Gas IndexTM 24.05% 108.32% 0.60% 1.68%   3.01% 8.75%
NASDAQ US Benchmark Energy Index 9.48% 86.93% -1.21% -0.07%   -5.91% -0.36%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Oil & Gas IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 8

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Oil & Gas ETF (FTXN) (Continued)
Sector Allocation % of Total
Investments
Energy 100.0%
Total 100.0%
Top Ten Holdings % of Total
Investments
SM Energy Co. 9.5%
Centennial Resource Development, Inc./DE, Class A 9.0
Cheniere Energy, Inc. 7.7
Williams (The) Cos., Inc. 7.2
Kinder Morgan, Inc. 7.1
Cabot Oil & Gas Corp. 4.7
Targa Resources Corp. 3.8
ONEOK, Inc. 3.8
Equitrans Midstream Corp. 3.7
ConocoPhillips 3.7
Total 60.2%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 9

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Pharmaceuticals ETF (FTXH)
The First Trust Nasdaq Pharmaceuticals ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Pharmaceuticals IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXH.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the pharmaceutical sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the pharmaceuticals sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes vaccine producers and manufacturers of prescription or over-the-counter drugs.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV 0.28% 7.58% 6.32% 6.00%   35.88% 34.05%
Market Price 0.32% 7.62% 6.32% 6.02%   35.84% 34.16%
Index Performance              
Nasdaq US Smart Pharmaceuticals IndexTM 0.63% 8.07% 7.01% 6.69%   40.31% 38.49%
NASDAQ US Benchmark Pharmaceuticals Index 6.09% 15.98% 11.54% 11.38%   72.63% 71.92%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Pharmaceuticals IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 10

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Pharmaceuticals ETF (FTXH) (Continued)
Sector Allocation % of Total
Investments
Health Care 100.0%
Total 100.0%
Top Ten Holdings % of Total
Investments
Prestige Consumer Healthcare, Inc. 8.2%
Merck & Co., Inc. 8.1
Pfizer, Inc. 7.8
Johnson & Johnson 7.8
AbbVie, Inc. 7.2
Catalent, Inc. 4.3
Horizon Therapeutics PLC 4.2
Alkermes PLC 4.1
Gilead Sciences, Inc. 4.0
Zoetis, Inc. 4.0
Total 59.7%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 11

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Retail ETF (FTXD)
The First Trust Nasdaq Retail ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Retail IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXD.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the retail sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the food & drug retailers sector or the general retailers sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes: (i) operators of pharmacies, including wholesalers and distributors catering to these businesses; (ii) supermarkets, food-oriented convenience stores and other food retailers and distributors; (iii) retailers and wholesalers specializing mainly in clothing, shoes, jewelry, sunglasses and other accessories; (iv) retail outlets and wholesalers; (v) retailers and wholesalers concentrating on the sale of home improvement products; (vi) providers of consumer services such as online marketplaces, auction houses, day-care centers, dry cleaners, schools, consumer rental companies, veterinary clinics, hair salons and providers of funerals, lawn maintenance, consumer storage, heating and cooling installation and plumbing services; and (vii) retailers and wholesalers concentrating on a single class of goods, such as electronics, books, automotive parts or closeouts.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV 8.63% 28.99% 12.58% 12.50%   80.81% 80.81%
Market Price 8.59% 28.98% 12.57% 12.51%   80.77% 80.87%
Index Performance              
Nasdaq US Smart Retail IndexTM 9.03% 29.88% 13.32% 13.23%   86.83% 86.80%
NASDAQ US Benchmark Retail Index 7.08% 14.94% 20.76% 21.09%   156.80% 161.73%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Retail IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 12

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Retail ETF (FTXD) (Continued)
Sector Allocation % of Total
Investments
Consumer Discretionary 72.6%
Consumer Staples 15.7
Health Care 7.6
Industrials 3.2
Energy 0.9
Total 100.0%
Top Ten Holdings % of Total
Investments
GameStop Corp., Class A 6.7%
CVS Health Corp. 5.8
AutoZone, Inc. 5.3
Walmart, Inc. 5.0
Kroger (The) Co. 4.7
O’Reilly Automotive, Inc. 4.4
Costco Wholesale Corp. 4.2
Target Corp. 3.9
Dollar General Corp. 3.9
Home Depot (The), Inc. 3.7
Total 47.6%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 13

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Semiconductor ETF (FTXL)
The First Trust Nasdaq Semiconductor ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Semiconductor IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXL.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the semiconductor sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the semiconductors sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes producers and distributors of semiconductors and other integrated chips, including other products related to the semiconductor industry, such as semiconductor capital equipment and motherboards.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV 4.12% 41.10% 27.46% 28.19%   236.36% 248.51%
Market Price 4.23% 41.37% 27.33% 28.23%   234.75% 249.03%
Index Performance              
Nasdaq US Smart Semiconductor IndexTM 4.45% 42.03% 28.28% 29.03%   247.35% 260.10%
NASDAQ US Benchmark Semiconductors Index 11.26% 36.10% 27.73% 28.49%   240.02% 252.71%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Semiconductor IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 14

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Semiconductor ETF (FTXL) (Continued)
Sector Allocation % of Total
Investments
Information Technology 100.0%
Total 100.0%
Top Ten Holdings % of Total
Investments
Texas Instruments, Inc. 8.3%
Intel Corp. 8.1
Broadcom, Inc. 8.0
Synaptics, Inc. 7.8
Amkor Technology, Inc. 7.5
ON Semiconductor Corp. 4.3
Analog Devices, Inc. 4.2
Cirrus Logic, Inc. 4.1
KLA Corp. 4.1
Micron Technology, Inc. 4.0
Total 60.4%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 15

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Transportation ETF (FTXR)
The First Trust Nasdaq Transportation ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Transportation IndexTM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXR.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).
The Index is designed to provide exposure to U.S. companies comprising the transportation sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the industrial transportation sector, the automobiles & parts sector or the airlines sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) operators of mail and package delivery services; (ii) providers of on-water transportation for commercial markets; (iii) providers of industrial railway transportation and railway lines; (iv) companies that manage airports, train depots, roads, bridges, tunnels, ports, and providers of logistic services to shippers of goods; (v) companies that provide commercial trucking services; (vi) makers of motorcycles and passenger vehicles; (vii) manufacturers and distributors of new and replacement parts for motorcycles and automobiles; (viii) manufacturers, distributors and retreaders of automobile, truck and motorcycle tires; and (ix) companies providing primarily passenger air transport.
Performance  
      Average Annual Total Returns   Cumulative Total Returns
  6 Months
Ended
9/30/21
1 Year
Ended
9/30/21
5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
  5 Years
Ended
9/30/21
Inception
(9/20/16)
to 9/30/21
Fund Performance              
NAV -5.80% 32.62% 9.64% 10.23%   58.40% 63.17%
Market Price -5.89% 32.52% 9.61% 10.22%   58.19% 63.11%
Index Performance              
Nasdaq US Smart Transportation IndexTM -5.89% 32.90% 10.21% 10.80%   62.56% 67.49%
NASDAQ US Benchmark Industrial Transportation Index -3.59% 15.39% 17.05% 17.83%   119.73% 128.16%
NASDAQ US Benchmark Index 8.40% 32.02% 17.03% 17.27%   119.50% 122.74%
(See Notes to Fund Performance Overview on page 20.)

Nasdaq® and Nasdaq US Smart Transportation IndexTM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.
Page 16

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Nasdaq Transportation ETF (FTXR) (Continued)
Sector Allocation % of Total
Long-Term
Investments
Industrials 80.1%
Consumer Discretionary 19.9
Total 100.0%
Top Ten Holdings % of Total
Long-Term
Investments
Expeditors International of Washington, Inc. 7.9%
United Rentals, Inc. 7.1
Old Dominion Freight Line, Inc. 6.9
Ford Motor Co. 6.6
CSX Corp. 5.6
General Motors Co. 4.3
Westinghouse Air Brake Technologies Corp. 4.0
PACCAR, Inc. 3.9
Norfolk Southern Corp. 3.9
JB Hunt Transport Services, Inc. 3.9
Total 54.1%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 17

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Indxx Medical Devices ETF (MDEV)
The First Trust Indxx Medical Devices ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an index called the Indxx Global Medical Equipment Index (the “Index”). The shares of the Fund are listed and traded on Cboe BZX Exchange, Inc. under the ticker symbol “MDEV.”
Under normal market conditions, the Fund will invest at least 80% of its net assets (plus any borrowings for investment purposes) in the common stocks and depositary receipts that comprise the Index. The Index is developed, maintained and sponsored by Indxx, LLC (the “Index Provider”). The Index is composed of common stock and depositary receipts issued by U.S. and non-U.S. companies that comprise the medical devices industry, as determined by the Index Provider. Companies comprising the medical devices industry are those companies that focus on developing equipment, instruments, and machines to diagnose, monitor, and treat diseases.
Performance
    Cumulative
Total Returns
    Inception (6/22/21)
to 9/30/21
Fund Performance    
NAV   2.70%
Market Value   2.94%
Index Performance    
Indxx Global Medical Equipment Index   3.09%
MSCI World Health Care Index   1.52%
(See Notes to Fund Performance Overview on page 20.)

Indxx and Indxx Global Medical Equipment Index are trademarks of Indxx, LLC (“Indxx”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Indxx, and Indxx makes no representation regarding the advisability of trading in such product. The Index is determined, composed and calculated by Indxx without regard to First Trust or the Fund.
Page 18

Table of Contents
Fund Performance Overview (Unaudited) (Continued)
First Trust Indxx Medical Devices ETF (MDEV) (Continued)
Sector Allocation % of Total
Investments
Health Care 100.0%
Total 100.0%
Top Ten Holdings % of Total
Investments
WuXi AppTec Co., Ltd., Class H 2.6%
DexCom, Inc. 2.6
West Pharmaceutical Services, Inc. 2.6
Straumann Holding AG 2.5
Sonova Holding AG 2.5
PerkinElmer, Inc. 2.5
Edwards Lifesciences Corp. 2.4
ResMed, Inc. 2.4
Terumo Corp. 2.4
Danaher Corp. 2.4
Total 24.9%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.
Frequency Distribution of Discounts and Premiums
Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.
Page 19

Table of Contents
Notes to Fund Performance Overview (Unaudited)
Total returns for the period since inception are calculated from the inception date of each Fund. “Average Annual Total Returns” represent the average annual change in value of an investment over the periods indicated. “Cumulative Total Returns” represent the total change in value of an investment over the periods indicated.
Each Fund’s per share net asset value (“NAV”) is the value of one share of the Fund and is computed by dividing the value of all assets of the Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of outstanding shares. The price used to calculate market return (“Market Price”) is determined by using the midpoint of the national best bid and offer price (“NBBO”) as of the time that the Fund’s NAV is calculated. Under SEC rules, the NBBO consists of the highest displayed buy and lowest sell prices among the various exchanges trading the Fund at the time the Fund’s NAV is calculated. Prior to January 1, 2019, the price used was the midpoint between the highest bid and the lowest offer on the stock exchange on which shares of the Fund were listed for trading as of the time that the Fund’s NAV was calculated. Since shares of each Fund did not trade in the secondary market until after the Fund’s inception, for the period from inception to the first day of secondary market trading in shares of the Fund, the NAV of each Fund is used as a proxy for the secondary market trading price to calculate market returns. NAV and market returns assume that all distributions have been reinvested in each Fund at NAV and Market Price, respectively.
An index is a statistical composite that tracks a specified financial market or sector. Unlike each Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by each Fund. These expenses negatively impact the performance of each Fund. Also, market returns do not include brokerage commissions that may be payable on secondary market transactions. If brokerage commissions were included, market returns would be lower. The total returns presented reflect the reinvestment of dividends on securities in the indices. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. The investment return and principal value of shares of each Fund will vary with changes in market conditions. Shares of each Fund may be worth more or less than their original cost when they are redeemed or sold in the market. Each Fund’s past performance is no guarantee of future performance.
Page 20

Table of Contents
First Trust Exchange-Traded Fund VI
Understanding Your Fund Expenses
September 30, 2021 (Unaudited)
As a shareholder of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust Nasdaq Retail ETF, First Trust Nasdaq Semiconductor ETF, First Trust Nasdaq Transportation ETF or First Trust Indxx Medical Devices ETF (each a “Fund” and collectively, the “Funds”), you incur two types of costs: (1) transaction costs; and (2) ongoing costs, including management fees, distribution and/or service (12b-1) fees, if any, and other Fund expenses. This Example is intended to help you understand your ongoing costs of investing in the Funds and to compare these costs with the ongoing costs of investing in other funds.
The Example is based on an investment of $1,000 invested at the beginning of the period (or since inception) and held through the six-month (or shorter) period ended September 30, 2021.
Actual Expenses
The first line in the following table provides information about actual account values and actual expenses. You may use the information in this line, together with the amount you invested, to estimate the expenses that you paid over the period. Simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number in the first line under the heading entitled “Expenses Paid During the Period” to estimate the expenses you paid on your account during this six-month (or shorter) period.
Hypothetical Example for Comparison Purposes
The second line in the following table provides information about hypothetical account values and hypothetical expenses based on each Fund’s actual expense ratio and an assumed rate of return of 5% per year before expenses, which is not each Fund’s actual return. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in the Funds and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.
Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs such as brokerage commissions. Therefore, the second line in the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.
  Beginning
Account Value
April 1, 2021
Ending
Account Value
September 30, 2021
Annualized
Expense Ratio
Based on the
Six-Month
Period
Expenses Paid
During the
Six-Month
Period (a)
First Trust Nasdaq Bank ETF (FTXO)
Actual $1,000.00 $1,056.30 0.60% $3.09
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
First Trust Nasdaq Food & Beverage ETF (FTXG)
Actual $1,000.00 $947.70 0.60% $2.93
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
First Trust Nasdaq Oil & Gas ETF (FTXN)
Actual $1,000.00 $1,234.70 0.60% $3.36
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
First Trust Nasdaq Pharmaceuticals ETF (FTXH)
Actual $1,000.00 $1,002.80 0.60% $3.01
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
First Trust Nasdaq Retail ETF (FTXD)
Actual $1,000.00 $1,086.30 0.60% $3.14
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
First Trust Nasdaq Semiconductor ETF (FTXL)
Actual $1,000.00 $1,041.20 0.60% $3.07
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
Page 21

Table of Contents
First Trust Exchange-Traded Fund VI
Understanding Your Fund Expenses (Continued)
September 30, 2021 (Unaudited)
  Beginning
Account Value
April 1, 2021
Ending
Account Value
September 30, 2021
Annualized
Expense Ratio
Based on the
Six-Month
Period
Expenses Paid
During the
Six-Month
Period (a)
First Trust Nasdaq Transportation ETF (FTXR)
Actual $1,000.00 $942.00 0.60% $2.92
Hypothetical (5% return before expenses) $1,000.00 $1,022.06 0.60% $3.04
  Beginning
Account Value
June 22, 2021 (b)
Ending
Account Value
September 30, 2021
Annualized
Expense Ratio
Based on the
the Number of Days
in the Period
Expenses Paid
During the Period
June 22, 2021 (b)
to September 30, 2021 (c)
First Trust Indxx Medical Devices ETF (MDEV)
Actual $1,000.00 $1,027.00 0.70% $1.96
Hypothetical (5% return before expenses) $1,000.00 $1,021.56 0.70% $3.55
    
(a) Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (April 1, 2021 through September 30, 2021), multiplied by 183/365 (to reflect the six-month period).
(b) Inception date.
(c) Actual expenses are equal to the annualized expense ratio as indicated in the table multiplied by the average account value over the period (June 22, 2021 through September 30, 2021), multiplied by 101/365. Hypothetical expenses are assumed for the most recent six-month period.
Page 22

Table of Contents
First Trust Nasdaq Bank ETF (FTXO)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.9%
    Banks – 88.2%    
101,371   Bank of America Corp.   $4,303,199
250,130   Citigroup, Inc.   17,554,123
205,376   Citizens Financial Group, Inc.   9,648,564
57,261   Comerica, Inc.   4,609,510
37,053   Cullen/Frost Bankers, Inc.   4,395,227
57,706   East West Bancorp, Inc.   4,474,523
231,433   Fifth Third Bancorp   9,822,017
4,714   First Citizens BancShares, Inc., Class A   3,974,703
548,716   First Horizon Corp.   8,938,584
45,206   First Republic Bank   8,719,333
272,519   Huntington Bancshares, Inc.   4,213,144
295,753   Investors Bancorp, Inc.   4,468,828
112,454   JPMorgan Chase & Co.   18,407,595
208,279   KeyCorp   4,502,992
30,228   M&T Bank Corp.   4,514,250
94,124   PNC Financial Services Group (The), Inc.   18,414,419
236,857   Popular, Inc.   18,396,683
207,158   Regions Financial Corp.   4,414,537
16,320   Signature Bank   4,443,610
37,460   Silvergate Capital Corp., Class A (a)   4,326,630
7,563   SVB Financial Group (a)   4,892,353
98,197   Synovus Financial Corp.   4,309,866
74,170   Truist Financial Corp.   4,350,071
73,744   US Bancorp   4,383,343
196,794   Wells Fargo & Co.   9,133,210
43,379   Western Alliance Bancorp   4,720,503
155,328   Zions Bancorp N.A.   9,613,250
        203,945,067
    Consumer Finance – 3.7%    
70,141   Discover Financial Services   8,616,822
    Thrifts & Mortgage Finance – 8.0%    
1,436,655   New York Community Bancorp, Inc.   18,489,750
    Total Investments – 99.9%   231,051,639
    (Cost $214,026,045) (b)    
    Net Other Assets and Liabilities – 0.1%   333,997
    Net Assets – 100.0%   $231,385,636
    

(a) Non-income producing security.
 
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $19,022,491 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $1,996,897. The net unrealized appreciation was $17,025,594.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $231,051,639 $231,051,639 $ $
    
* See Portfolio of Investments for industry breakout.
 
See Notes to Financial Statements
Page 23

Table of Contents
First Trust Nasdaq Food & Beverage ETF (FTXG)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.9%
    Beverages – 19.5%    
143   Boston Beer (The) Co., Inc., Class A (a)   $72,894
1,165   Brown-Forman Corp., Class B   78,067
4,359   Coca-Cola (The) Co.   228,717
387   Constellation Brands, Inc., Class A   81,537
6,881   Keurig Dr. Pepper, Inc.   235,055
1,721   Molson Coors Beverage Co., Class B   79,820
839   Monster Beverage Corp. (a)   74,528
1,758   National Beverage Corp.   92,278
1,569   PepsiCo, Inc.   235,993
        1,178,889
    Chemicals – 3.9%    
5,582   Corteva, Inc.   234,890
    Food & Staples Retailing – 1.4%    
2,406   US Foods Holding Corp. (a)   83,392
    Food Products – 74.0%    
8,182   Archer-Daniels-Midland Co.   491,002
8,085   B&G Foods, Inc.   241,661
684   Beyond Meat, Inc. (a)   71,998
6,484   Bunge Ltd.   527,279
1,961   Campbell Soup Co.   81,989
7,411   Conagra Brands, Inc.   251,011
6,589   Darling Ingredients, Inc. (a)   473,749
4,246   General Mills, Inc.   253,996
2,762   Hershey (The) Co.   467,468
1,797   Hormel Foods Corp.   73,677
931   Ingredion, Inc.   82,868
1,985   JM Smucker (The) Co.   238,259
3,887   Kellogg Co.   248,457
2,273   Kraft Heinz (The) Co.   83,692
1,256   Lamb Weston Holdings, Inc.   77,081
948   McCormick & Co., Inc.   76,816
3,954   Mondelez International, Inc., Class A   230,044
6,252   Tyson Foods, Inc., Class A   493,533
        4,464,580
    Specialty Retail – 1.1%    
2,558   GrowGeneration Corp. (a)   63,106
    Total Investments – 99.9%   6,024,857
    (Cost $6,316,421) (b)    
    Net Other Assets and Liabilities – 0.1%   7,779
    Net Assets – 100.0%   $6,032,636
    

(a) Non-income producing security.
 
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $18,174 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $309,738. The net unrealized depreciation was $291,564.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $6,024,857 $6,024,857 $ $
    
* See Portfolio of Investments for industry breakout.
 
Page 24
See Notes to Financial Statements

Table of Contents
First Trust Nasdaq Oil & Gas ETF (FTXN)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 100.0%
    Energy Equipment &
Services – 4.4%
   
33,260   Baker Hughes Co.   $822,520
5,846   ChampionX Corp. (a)   130,717
6,828   Halliburton Co.   147,621
5,066   Helmerich & Payne, Inc.   138,859
1,617   Nabors Industries Ltd. (a)   156,008
10,354   NOV, Inc. (a)   135,741
4,863   Schlumberger N.V.   144,139
123,803   Transocean Ltd. (a)   469,214
        2,144,819
    Oil, Gas & Consumable Fuels – 95.6%    
170,247   Antero Midstream Corp.   1,773,974
68,575   Antero Resources Corp. (a)   1,289,896
17,186   APA Corp.   368,296
106,512   Cabot Oil & Gas Corp.   2,317,701
3,989   Callon Petroleum Co. (a)   195,780
663,724   Centennial Resource Development, Inc./DE, Class A (a)   4,446,951
38,705   Cheniere Energy, Inc.   3,780,317
17,489   Chevron Corp.   1,774,259
69,490   CNX Resources Corp. (a)   876,964
100,486   Comstock Resources, Inc. (a)   1,040,030
26,911   ConocoPhillips   1,823,758
7,973   Delek US Holdings, Inc. (a)   143,275
23,005   Devon Energy Corp.   816,908
1,769   Diamondback Energy, Inc.   167,471
4,223   EOG Resources, Inc.   338,980
9,544   EQT Corp. (a)   195,270
179,884   Equitrans Midstream Corp.   1,824,024
17,198   Exxon Mobil Corp.   1,011,586
3,298   Hess Corp.   257,607
4,220   HollyFrontier Corp.   139,809
208,050   Kinder Morgan, Inc.   3,480,676
57,799   Kosmos Energy Ltd. (a)   171,085
94,599   Magnolia Oil & Gas Corp., Class A   1,682,916
67,975   Marathon Oil Corp.   929,218
23,047   Marathon Petroleum Corp.   1,424,535
4,745   Matador Resources, Co.   180,500
6,416   Murphy Oil Corp.   160,207
5,311   Occidental Petroleum Corp.   157,099
32,228   ONEOK, Inc.   1,868,902
5,004   Ovintiv, Inc.   164,531
13,113   PBF Energy, Inc., Class A (a)   170,076
23,233   PDC Energy, Inc.   1,101,012
1,920   Phillips 66   134,458
909   Pioneer Natural Resources Co.   151,358
9,331   Range Resources Corp. (a)   211,161
177,222   SM Energy Co.   4,675,116
29,981   Southwestern Energy Co. (a)   166,095
38,539   Targa Resources Corp.   1,896,504
42,756   Tellurian, Inc. (a)   167,176
Shares   Description   Value
    Oil, Gas & Consumable
Fuels (Continued)
   
2,054   Valero Energy Corp.   $144,951
137,097   Williams (The) Cos., Inc.   3,556,296
        47,176,728
    Total Investments – 100.0%   49,321,547
    (Cost $44,887,545) (b)    
    Net Other Assets and Liabilities – 0.0%   13,357
    Net Assets – 100.0%   $49,334,904
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $4,911,498 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $477,496. The net unrealized appreciation was $4,434,002.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $49,321,547 $49,321,547 $ $
    
* See Portfolio of Investments for industry breakout.
 
See Notes to Financial Statements
Page 25

Table of Contents
First Trust Nasdaq Pharmaceuticals ETF (FTXH)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.9%
    Biotechnology – 31.7%    
11,917   AbbVie, Inc.   $1,285,487
23,846   Alkermes PLC (a)   735,411
8,852   BioMarin Pharmaceutical, Inc. (a)   684,171
3,130   Blueprint Medicines Corp. (a)   321,795
10,242   Gilead Sciences, Inc.   715,404
6,896   Horizon Therapeutics PLC (a)   755,388
7,343   Ionis Pharmaceuticals, Inc. (a)   246,284
3,469   United Therapeutics Corp. (a)   640,308
1,458   Vertex Pharmaceuticals, Inc. (a)   264,466
        5,648,714
    Health Care Providers &
Services – 3.9%
   
14,201   Cardinal Health, Inc.   702,382
    Pharmaceuticals – 64.3%    
11,149   Bristol-Myers Squibb Co.   659,686
5,715   Catalent, Inc. (a)   760,495
13,720   Corcept Therapeutics, Inc. (a)   270,010
8,747   Elanco Animal Health, Inc. (a)   278,942
2,886   Eli Lilly & Co.   666,810
127,498   Endo International PLC (a)   413,093
22,425   Esperion Therapeutics, Inc. (a)   270,221
2,217   Jazz Pharmaceuticals PLC (a)   288,676
8,611   Johnson & Johnson   1,390,676
19,320   Merck & Co., Inc.   1,451,125
27,649   Ocular Therapeutix, Inc. (a)   276,490
4,924   Pacira BioSciences, Inc. (a)   275,744
7,130   Perrigo Co. PLC   337,463
32,361   Pfizer, Inc.   1,391,847
25,978   Prestige Consumer Healthcare, Inc. (a)   1,457,626
367,257   TherapeuticsMD, Inc. (a)   272,284
3,644   Zoetis, Inc.   707,446
19,714   Zogenix, Inc. (a)   299,456
        11,468,090
    Total Investments – 99.9%   17,819,186
    (Cost $17,131,742) (b)    
    Net Other Assets and Liabilities – 0.1%   24,378
    Net Assets – 100.0%   $17,843,564
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $1,848,370 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $1,160,926. The net unrealized appreciation was $687,444.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $17,819,186 $17,819,186 $ $
    
* See Portfolio of Investments for industry breakout.
 
Page 26
See Notes to Financial Statements

Table of Contents
First Trust Nasdaq Retail ETF (FTXD)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 100.0%
    Commercial Services &
Supplies – 1.1%
   
1,767   Copart, Inc. (a)   $245,118
    Diversified Consumer
Services – 0.8%
   
2,465   Chegg, Inc. (a)   167,669
    Food & Staples Retailing – 15.6%    
2,060   Costco Wholesale Corp.   925,661
25,511   Kroger (The) Co.   1,031,410
2,574   Sysco Corp.   202,059
4,039   Walgreens Boots Alliance, Inc.   190,035
8,001   Walmart, Inc.   1,115,179
        3,464,344
    Health Care Providers &
Services – 7.6%
   
1,678   AmerisourceBergen Corp.   200,437
15,077   CVS Health Corp.   1,279,434
1,005   McKesson Corp.   200,377
        1,680,248
    Internet & Direct Marketing
Retail – 6.7%
   
58   Amazon.com, Inc. (a)   190,532
2,327   Chewy, Inc., Class A (a)   158,492
4,806   eBay, Inc.   334,834
948   Etsy, Inc. (a)   197,146
2,840   Overstock.com, Inc. (a)   221,293
4,892   Stitch Fix, Inc., Class A (a)   195,436
730   Wayfair, Inc., Class A (a)   186,522
        1,484,255
    Multiline Retail – 17.0%    
4,016   Dollar General Corp.   851,954
7,994   Dollar Tree, Inc. (a)   765,186
8,666   Kohl’s Corp.   408,082
22,812   Macy’s, Inc.   515,551
7,166   Nordstrom, Inc. (a)   189,541
2,832   Ollie’s Bargain Outlet Holdings, Inc. (a)   170,713
3,804   Target Corp.   870,241
        3,771,268
    Oil, Gas & Consumable Fuels – 1.0%    
25,853   Clean Energy Fuels Corp. (a)   210,702
    Road & Rail – 2.1%    
4,306   Lyft, Inc., Class A (a)   230,759
5,238   Uber Technologies, Inc. (a)   234,662
        465,421
    Specialty Retail – 48.1%    
3,362   Advance Auto Parts, Inc.   702,288
Shares   Description   Value
    Specialty Retail (Continued)    
6,717   American Eagle Outfitters, Inc.   $173,299
695   AutoZone, Inc. (a)   1,180,103
3,038   Bath & Body Works, Inc.   191,485
7,444   Bed Bath & Beyond, Inc. (a)   128,595
7,334   Best Buy Co., Inc.   775,277
684   Burlington Stores, Inc. (a)   193,962
1,637   CarMax, Inc. (a)   209,470
625   Carvana Co. (a)   188,462
6,669   Dick’s Sporting Goods, Inc.   798,746
963   Five Below, Inc. (a)   170,268
8,511   GameStop Corp., Class A (a)   1,493,425
7,670   Gap (The), Inc.   174,109
2,470   Home Depot (The), Inc.   810,802
617   Lithia Motors, Inc.   195,614
2,215   Lowe’s Cos., Inc.   449,335
1,579   O’Reilly Automotive, Inc. (a)   964,864
294   RH (a)   196,072
1,732   Ross Stores, Inc.   188,528
2,819   TJX (The) Cos., Inc.   185,998
1,306   Tractor Supply Co.   264,609
529   Ulta Beauty, Inc. (a)   190,927
3,092   Victoria’s Secret & Co. (a)   170,864
3,604   Williams-Sonoma, Inc.   639,097
        10,636,199
    Total Investments – 100.0%   22,125,224
    (Cost $22,268,199) (b)    
    Net Other Assets and Liabilities – 0.0%   9,884
    Net Assets – 100.0%   $22,135,108
    

(a) Non-income producing security.
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $776,769 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $919,744. The net unrealized depreciation was $142,975.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $22,125,224 $22,125,224 $ $
    
* See Portfolio of Investments for industry breakout.
 
See Notes to Financial Statements
Page 27

Table of Contents
First Trust Nasdaq Semiconductor ETF (FTXL)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.8%
    Electronic Equipment,
Instruments & Components – 2.6%
   
17,621   II-VI, Inc. (a)   $1,045,983
6,503   IPG Photonics Corp. (a)   1,030,075
        2,076,058
    Semiconductors &
Semiconductor Equipment – 97.2%
   
10,024   Advanced Micro Devices, Inc. (a)   1,031,470
10,715   Ambarella, Inc. (a)   1,668,754
242,174   Amkor Technology, Inc.   6,042,241
20,414   Analog Devices, Inc.   3,418,937
24,616   Applied Materials, Inc.   3,168,818
13,379   Broadcom, Inc.   6,487,878
13,062   Brooks Automation, Inc.   1,336,896
39,753   Cirrus Logic, Inc. (a)   3,273,660
13,060   Cree, Inc. (a)   1,054,334
9,238   Entegris, Inc.   1,163,064
123,057   Intel Corp.   6,556,477
9,785   KLA Corp.   3,273,180
5,473   Lam Research Corp.   3,114,958
17,865   Lattice Semiconductor Corp. (a)   1,154,972
18,138   Marvell Technology, Inc.   1,093,903
7,053   Microchip Technology, Inc.   1,082,565
45,131   Micron Technology, Inc.   3,203,398
2,242   Monolithic Power Systems, Inc.   1,086,653
4,959   NVIDIA Corp.   1,027,306
15,461   NXP Semiconductors N.V.   3,028,346
74,982   ON Semiconductor Corp. (a)   3,431,926
17,690   Qorvo, Inc. (a)   2,957,591
22,676   QUALCOMM, Inc.   2,924,750
7,040   Silicon Laboratories, Inc. (a)   986,726
6,049   Skyworks Solutions, Inc.   996,754
35,055   Synaptics, Inc. (a)   6,300,435
9,139   Teradyne, Inc.   997,705
34,846   Texas Instruments, Inc.   6,697,750
        78,561,447
    Total Investments – 99.8%   80,637,505
    (Cost $76,729,370) (b)    
    Net Other Assets and Liabilities – 0.2%   145,561
    Net Assets – 100.0%   $80,783,066
    

(a) Non-income producing security.
 
(b) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $5,414,098 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $1,505,963. The net unrealized appreciation was $3,908,135.

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $80,637,505 $80,637,505 $ $
    
* See Portfolio of Investments for industry breakout.
 
Page 28
See Notes to Financial Statements

Table of Contents
First Trust Nasdaq Transportation ETF (FTXR)
Portfolio of Investments
September 30, 2021 (Unaudited)
Shares   Description   Value
COMMON STOCKS – 99.9%
    Air Freight & Logistics – 20.3%    
416,097   CH Robinson Worldwide, Inc.   $36,200,439
714,149   Expeditors International of Washington, Inc.   85,076,570
167,510   FedEx Corp.   36,733,268
247,426   GXO Logistics, Inc. (a)   19,408,095
227,499   United Parcel Service, Inc., Class B   41,427,568
        218,845,940
    Airlines – 13.5%    
352,929   Alaska Air Group, Inc. (a)   20,681,639
1,014,891   American Airlines Group, Inc. (a)   20,825,563
500,419   Delta Air Lines, Inc. (a)   21,322,853
1,337,537   JetBlue Airways Corp. (a)   20,450,941
406,527   Southwest Airlines Co. (a)   20,907,684
824,987   Spirit Airlines, Inc. (a)   21,400,163
435,109   United Airlines Holdings, Inc. (a)   20,698,135
        146,286,978
    Auto Components – 5.5%    
264,330   Aptiv PLC (a)   39,377,240
474,155   BorgWarner, Inc.   20,488,238
        59,865,478
    Automobiles – 14.4%    
5,036,702   Ford Motor Co. (a)   71,319,700
887,165   General Motors Co. (a)   46,762,467
27,507   Tesla, Inc. (a)   21,331,129
2,062,888   Workhorse Group, Inc. (a) (b)   15,781,093
        155,194,389
    Electrical Equipment – 3.6%    
1,372,365   Blink Charging Co. (a) (b)   39,263,363
    Machinery – 9.8%    
1,940,262   Nikola Corp. (a) (b)   20,702,595
537,248   PACCAR, Inc.   42,399,612
495,665   Westinghouse Air Brake Technologies Corp.   42,731,280
        105,833,487
    Road & Rail – 25.7%    
2,024,334   CSX Corp.   60,203,693
250,878   JB Hunt Transport Services, Inc.   41,951,819
175,538   Norfolk Southern Corp.   41,997,467
261,000   Old Dominion Freight Line, Inc.   74,640,780
205,247   Union Pacific Corp.   40,230,465
232,849   XPO Logistics, Inc. (a)   18,530,123
        277,554,347
Shares   Description   Value
    Trading Companies &
Distributors – 7.1%
   
218,376   United Rentals, Inc. (a)   $76,634,690
    Total Common Stocks   1,079,478,672
    (Cost $1,064,428,940)    
MONEY MARKET FUNDS – 3.0%
32,929,024   Goldman Sachs Financial Square Treasury Obligations Fund - Institutional Class - 0.01% (c) (d)   32,929,024
    (Cost $32,929,024)    
Principal
Value
  Description   Value
REPURCHASE AGREEMENTS – 3.2%
$34,165,951   BNP Paribas S.A., 0.03% (c), dated 9/30/21, due 10/1/21, with a maturity value of $34,165,980. Collateralized by U.S. Treasury Notes, interest rates of 0.375% to 0.750%, due 4/15/24 to 1/31/28. The value of the collateral including accrued interest is $35,033,807. (d)   34,165,951
    (Cost $34,165,951)    
    Total Investments – 106.1%   1,146,573,647
    (Cost $1,131,523,915) (e)    
    Net Other Assets and Liabilities – (6.1)%   (66,381,084)
    Net Assets – 100.0%   $1,080,192,563
    

(a) Non-income producing security.
(b) All or a portion of this security is on loan (See Note 2D - Securities Lending in the Notes to Financial Statements). The remaining contractual maturity of all of the securities lending transactions is overnight and continuous. The aggregate value of such securities is $66,196,692 and the total value of the collateral held by the Fund is $67,094,975.
(c) Rate shown reflects yield as of September 30, 2021.
(d) This security serves as collateral for securities on loan.
(e) Aggregate cost for financial reporting purposes approximates the aggregate cost for federal income tax purposes. As of September 30, 2021, the aggregate gross unrealized appreciation for all investments in which there was an excess of value over tax cost was $76,535,312 and the aggregate gross unrealized depreciation for all investments in which there was an excess of tax cost over value was $61,485,580. The net unrealized appreciation was $15,049,732.
 
See Notes to Financial Statements
Page 29

Table of Contents
First Trust Nasdaq Transportation ETF (FTXR)
Portfolio of Investments (Continued)
September 30, 2021 (Unaudited)

Valuation Inputs
A summary of the inputs used to value the Fund’s investments as of September 30, 2021 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):
  Total
Value at
9/30/2021
Level 1
Quoted
Prices
Level 2
Significant
Observable
Inputs
Level 3
Significant
Unobservable
Inputs
Common Stocks* $1,079,478,672 $1,079,478,672 $ $
Money Market Funds 32,929,024 32,929,024
Repurchase Agreements 34,165,951 34,165,951
Total Investments $1,146,573,647 $1,112,407,696 $34,165,951