Caution Regarding Forward-Looking Statements

This report contains certain forward-looking statements within the meaning of the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended. Forward-looking statements include statements regarding the goals, beliefs, plans or current expectations of First Trust Advisors L.P. (“First Trust” or the “Advisor”) and its representatives, taking into account the information currently available to them. Forward-looking statements include all statements that do not relate solely to current or historical fact. For example, forward-looking statements include the use of words such as “anticipate,” “estimate,” “intend,” “expect,” “believe,” “plan,” “may,” “should,” “would” or other words that convey uncertainty of future events or outcomes.

Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of any series of First Trust Exchange-Traded Fund VI (the “Trust”) described in this report (each such series is referred to as a “Fund” and collectively, the “Funds”) to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. When evaluating the information included in this report, you are cautioned not to place undue reliance on these forward-looking statements, which reflect the judgment of the Advisor and its representatives only as of the date hereof. We undertake no obligation to publicly revise or update these forward-looking statements to reflect events and circumstances that arise after the date hereof.

Performance and Risk Disclosure

There is no assurance that any Fund described in this report will achieve its investment objective. Each Fund is subject to market risk, which is the possibility that the market values of securities owned by the Fund will decline and that the value of the Fund’s shares may therefore be less than what you paid for them. Accordingly, you can lose money by investing in a Fund. See “Risk Considerations” in the Additional Information section of this report for a discussion of certain other risks of investing in the Funds.

Performance data quoted represents past performance, which is no guarantee of future results, and current performance may be lower or higher than the figures shown. For the most recent month-end performance figures, please visit www.ftportfolios.com or speak with your financial advisor. Investment returns, net asset value and share price will fluctuate and Fund shares, when sold, may be worth more or less than their original cost.

The Advisor may also periodically provide additional information on Fund performance on each Fund’s web page at www.ftportfolios.com.

How to Read This Report

This report contains information that may help you evaluate your investment. It includes details about each Fund and presents data and analysis that provide insight into each Fund’s performance and investment approach.

By reading the market overview by Robert F. Carey, Chief Market Strategist of the Advisor, you may obtain an understanding of how the market environment affected the performance of each Fund. The statistical information that follows may help you understand each Fund’s performance compared to that of relevant market benchmarks.

It is important to keep in mind that the opinions expressed by personnel of the Advisor are just that: informed opinions. They should not be considered to be promises or advice. The opinions, like the statistics, cover the period through the date on the cover of this report. The material risks of investing in each Fund are spelled out in the prospectus, the statement of additional information, and other Fund regulatory filings.

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Shareholder Letter

First Trust Exchange-Traded Fund VI

Annual Letter from the Chairman and CEO

March 31, 2022

Dear Shareholders,

First Trust is pleased to provide you with the annual report for certain series of the First Trust Exchange-Traded Fund VI (the “Funds”), which contains detailed information about the Funds for the twelve months ended March 31, 2022. Please note that the First Trust S-Network Streaming & Gaming ETF (“BNGE”) was incepted after the start of the reporting period, so information in this letter and the report prior to the Fund’s inception date of January 25, 2022, will not apply to that Fund.

How are investors expected to make sense of the markets in a climate like the one we are in today? For what it is worth, the famous adage that “perception is reality” is a complete misnomer, in my opinion. Perception is a perspective of reality. Reality is the truth. When it comes to investing one’s capital, it can be difficult to ascertain the truth, especially in the age of the internet and the 24/7 news cycle. There is so much information pumped out daily pertaining to the securities markets that it can be counterproductive if you consume too much of it, particularly if you do not have a discerning eye. To be frank, a lot of financial information adds up to nothing more than noise, or is an extension of someone’s agenda, and we at First Trust encourage investors to ignore it as best they can. That is why we believe that investors should lean on those market principles that are tried and true. That is how you make sense of the markets, in my opinion.

There is essentially nothing major transpiring around the globe today that we have not encountered to some degree before, including war. Even the coronavirus (“COVID-19”) pandemic, which arrived in the U.S. in the first quarter of 2020, was somewhat matched in scope by the 1918 flu (Spanish flu) pandemic. Approximately 987,000 lives have been lost so far in the U.S. from the COVID-19 pandemic, compared to 675,000 spanning the 1918 flu pandemic, according to data from the Centers for Disease Control and Prevention. While we have had more deaths from the COVID-19 virus, the speed in which no fewer than three effective vaccines were brought to bear to combat this virus was astounding. U.S. ingenuity is what keeps this country ascending, in my opinion. I believe it to be one of the main reasons why the investment philosophy “time in the market” has been such a tried and true principle of the wealth building process. Endure the ups and downs of the stock market and you can persevere over time. In the short-run, it is anybody’s guess, and guessing should not play any role in developing a financial plan. History is on your side. Keep in mind, the S&P 500^® Index has never failed to fully recover any losses sustained in a downturn and it stood at its all-time closing high on January 3, 2022.

The stock and bond markets have been more volatile of late and may stay that way, at least over the near-term. Based on some thorough guidance from the Federal Reserve (the “Fed”) with respect to its bias towards raising short-term interest rates more aggressively than once thought to fight inflation, there is a good chance that the days of artificially low interest rates are finally coming to an end. Bond yields have spiked recently to reflect the surge in inflation, which stood at 8.5% on a trailing 12-month basis in March 2022, and the anticipated rate hikes from the Fed. In other words, interest rates and bond yields are in the process of normalizing. What is normal? Well, the Federal Funds target rate (upper bound), which stood at 0.50% at the close on April 21, 2022, averaged 2.48% for the 30-year period ended April 21, 2022, according to Bloomberg. It reached as high as 6.50% in 2000. The yield on the 10-Year Treasury Note (“T-Note”), which stood at 2.91% at the close on April 21, 2022, averaged 3.98% over that same 30-year period. The 10-Year T-Note reached as high as 8.03% in 1994. All eyes will likely be on the Fed for the remainder of this year. The economy is still growing, albeit at a slower clip, and it looks like more Americans are heading back to work. Keep an eye on interest rates, bond yields and inflation in the months ahead. We would prefer slow and steady as they rise as opposed to sharp moves higher. As always, stay the course!

Thank you for giving First Trust the opportunity to play a role in your financial future. We value our relationship with you and will report on the Funds again in six months.

Sincerely,

James A. Bowen

Chairman of the Board of Trustees

Chief Executive Officer of First Trust Advisors L.P.

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Market Overview

First Trust Exchange-Traded Fund VI

Annual Report

March 31, 2022

Robert F. Carey, CFA

Senior Vice President and Chief Market Strategist

First Trust Advisors L.P.

Mr. Carey is responsible for the overall management of research and analysis of the First Trust product line. Mr. Carey has more than 30 years of experience as an Equity and Fixed-Income Analyst and is a recipient of the Chartered Financial Analyst (“CFA”) designation. He is a graduate of the University of Illinois at Champaign-Urbana with a B.S. in Physics. He is also a member of the Investment Analysts Society of Chicago and the CFA Institute. Mr. Carey has appeared as a guest on such programs as Bloomberg TV, CNBC, and WBBM Radio, and has been quoted by several publications, including The Wall Street Journal, The Wall Street Reporter, Bloomberg News Service, and Registered Rep.

State of the Global Economy

The latest global growth forecast from the International Monetary Fund (“IMF”) released in April 2022 sees real gross domestic product growth rising by 3.6% worldwide in 2022, down from its 4.4% projection in January 2022. The IMF is calling for a 3.7% growth rate for the U.S., down from its January estimate of 4.0%. Emerging Market and Developing Economies are expected to grow by 3.8% this year, down markedly from the IMF’s 4.8% estimate in January. While global growth is expected to slow some in 2022, there does not appear to be a significant threat of recession in the near-term. The IMF notes that the reduction in its economic growth targets is largely a byproduct of Russia’s decision to invade Ukraine back on February 24, 2022.

Robust inflation and the war between Russia and Ukraine have been the dominant stories of late, in our opinion. Inflation, as measured by the Consumer Price Index, stood at 8.5% on a trailing 12-month basis at the end of March 2022, according to the U.S. Bureau of Labor Statistics. The last time inflation in the U.S. was this high was in 1982. Consumer prices are up significantly across the board, including groceries, gasoline, automobiles, homes, and apartment rents. It has been reported that the war between Russia and Ukraine could lead to global food shortages. It has already helped drive energy prices higher. These two events are worth monitoring closely. If one or both end up being protracted, then we would anticipate higher levels of volatility in the markets moving forward. Perhaps the biggest beneficiary of the spike in inflation is commodity prices, which surged 27.03% in the first quarter of 2022, as measured by the Refinitiv/CC CRB Excess Return Index.

Performance of Global Stocks and Bonds

The major U.S. stock indices delivered mixed results over the past 12 months. The S&P 500^®, S&P MidCap 400^® and S&P SmallCap 600^® Indices posted total returns of 15.65%, 4.59% and 1.23%, respectively, for the 12-month period ended March 31, 2022. Due to the ongoing economic headwinds stemming from the coronavirus pandemic, rising inflation, and, more recently, the war between Russia and Ukraine, large-capitalization (“cap”) stocks outperformed their mid- and small-cap counterparts over the period, an indication that investors were somewhat concerned about the level of risk they were willing to assume, in our opinion. Ten of the 11 major sectors that comprise the S&P 500^® Index (the “Index”) were up on a total return basis for the period. The top performer was the Energy sector, up 64.30%, while the worst showing came from Communication Services, down 0.93%.

A Bloomberg survey of 24 equity strategists found that their average 2022 year-end price target for the Index was 4,868 as of April 2022, according to its own release. The highest and lowest estimates were 5,330 and 4,400, respectively. Brian Wesbury, Chief Economist at First Trust, announced in May 2022 that he is looking for a year-end price target of 4,900, a downward revision from his 5,250 projection at the close of 2021. The Index closed trading on March 31, 2022, at 4,530.41. The outlook for corporate earnings remains optimistic. Bloomberg’s consensus year-over-year earnings growth rate estimates for the Index for 2022 and 2023 were 10.25% and 9.44%, respectively, as of April 1, 2022.

The broader foreign stock indices lagged the performance of the major U.S. stock indices. Over the past 12 months, the MSCI World ex USA and MSCI Emerging Markets equity indices posted total returns of 3.04% (USD) and -11.37% (USD), respectively, according to Bloomberg. The major foreign bond indices were down over the same period. The Bloomberg Global Aggregate Index of higher quality debt posted a total return of -6.40% (USD), while the Bloomberg EM Hard Currency Aggregate Index of emerging markets debt declined by 8.80% (USD), according to Bloomberg. The U.S. dollar rose by 5.45% over the past 12 months against a basket of major currencies, as measured by the U.S. Dollar Index (DXY). The sizable jump in the dollar provided a drag on the performance of both foreign stock and bond indices, in our opinion.

In the U.S. bond market, the results were also disappointing. The top-performing major debt group we track was speculative-grade corporate bonds. The Bloomberg U.S. Corporate High Yield Index posted a total return of -0.66% for the 12-month period ended March 31, 2022. The worst-performing U.S. debt group that we track was long-term municipal bonds. The Bloomberg Municipal Bond: Long Bond (22+ years) posted a total return of -5.30%. The yield on the benchmark 10-Year Treasury Note (“T-Note”) rose by 60 basis points in the period to close at 2.34% on March 31, 2022, according to Bloomberg. For comparative purposes, the average yield on the 10-Year T-Note was 2.03% for the 10-year period ended March 31, 2022.

Table of Contents

Fund Performance Overview (Unaudited)

First Trust Nasdaq Bank ETF (FTXO)

The First Trust Nasdaq Bank ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Banks Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXO.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the banking sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the banking sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes companies providing a broad range of financial services, including retail banking, loans and money transmissions.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	3.89%	6.79%	11.27%	38.89%	80.40%
Market Price	3.99%	6.79%	11.28%	38.87%	80.52%
Index Performance
Nasdaq US Smart Banks Index^TM	4.59%	7.51%	12.03%	43.60%	87.30%
NASDAQ US Benchmark Banks Index	2.21%	8.43%	13.03%	49.86%	96.79%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a net asset value (“NAV”) return of 3.89% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index generated a return of 12.05%, and the NASDAQ US Benchmark Banks Index (the “Benchmark”) generated a return of 2.21%. The Banking industry carried most of the weight in the Fund as well as in the Benchmark. This industry had a weight of 90.3% in the Fund and 96.1% in the Benchmark, which included the Diversified Banks and Regional Banks sub-industries. The Regional Banks sub-industry received a 68.6% allocation in the Fund and provided the largest contribution to the Fund’s return at 5.9%. The sole negative contribution to the Fund’s return was the -1.1% contribution from the Diversified Banks sub-industry. On a relative basis, the Fund outperformed the Benchmark. The largest source of relative outperformance came from the Regional Banks sub-industry which earned 4.7% of outperformance for the Fund versus the Benchmark. Both the Diversified Banks and Regional Banks sub-industries were positive contributors to relative performance. The Fund invested nominally in several other sub-sectors, but none were significant contributors to the performance of the Fund or the Benchmark during the period covered by this report.

Nasdaq^® and Nasdaq US Smart Banks Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

Page 4

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Bank ETF (FTXO) (Continued)

Sector Allocation	% of Total Investments
Financials	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Zions Bancorp N.A.	8.1%
Wells Fargo & Co.	7.9
KeyCorp	7.8
Popular, Inc.	7.8
Citizens Financial Group, Inc.	7.6
JPMorgan Chase & Co.	4.2
Comerica, Inc.	4.1
Bank of America Corp.	4.1
Synovus Financial Corp.	4.1
M&T Bank Corp.	4.1
Total	59.8%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.

Frequency Distribution of Discounts and Premiums

Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Food & Beverage ETF (FTXG)

The First Trust Nasdaq Food & Beverage ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Food & Beverage Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXG.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the food and beverage sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the beverages sector or food producers sector according to the Industry Classification Benchmark (“ICB”). The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) manufacturers and shippers of cider or malt products; (ii) producers, distillers, vintners, blenders and shippers of wine and spirits; (iii) manufacturers, bottlers and distributors of non-alcoholic beverages; (iv) companies that grow crops or raise livestock, operate fisheries or own non-tobacco plantations; (v) food producers, including meatpacking, snacks, fruits, vegetables, dairy products and frozen seafood; (vi) producers of pet food; and (vii) manufacturers of dietary supplements, vitamins and related items.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	7.13%	7.12%	7.16%	41.02%	46.54%
Market Price	5.72%	7.13%	7.19%	41.09%	46.75%
Index Performance
Nasdaq US Smart Food & Beverage Index^TM	7.79%	7.81%	7.85%	45.62%	51.86%
NASDAQ US Benchmark Food, Beverage and Tobacco Index	12.23%	9.36%	9.16%	56.42%	62.33%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 7.13% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index generated a return of 12.05%, and the NASDAQ US Benchmark Food, Beverage, and Tobacco Index (the “Benchmark”) generated a return of 12.23%. The Food Products sub-industry received an allocation of 73.7% in the Fund during the period and contributed 9.7% to the Fund’s return. The most negatively contributing industry investments during the period were in the Specialty Retail industry, which carried a relatively low average weight of only 2.6% but contributed -3.5% to the Fund’s overall return. On a relative basis, the Fund underperformed the Benchmark. The greatest source of underperformance came from investments in the Specialty Retail industry which caused -3.7% of underperformance relative to the Benchmark. The greatest source of outperformance came from investments in the Food Products industry, which caused 2.0% of outperformance for the Fund versus the Benchmark.

Nasdaq^® and Nasdaq US Smart Food & Beverage Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Food & Beverage ETF (FTXG) (Continued)

Sector Allocation	% of Total Investments
Consumer Staples	95.7%
Materials	4.3
Total	100.0%

Top Ten Holdings	% of Total Investments
Archer-Daniels-Midland Co.	9.0%
Bunge Ltd.	8.3
Tyson Foods, Inc., Class A	7.6
Hershey (The) Co.	6.5
Conagra Brands, Inc.	5.9
Corteva, Inc.	4.3
McCormick & Co., Inc.	4.1
PepsiCo, Inc.	4.0
Hostess Brands, Inc.	4.0
Kellogg Co.	3.9
Total	57.6%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Oil & Gas ETF (FTXN)

The First Trust Nasdaq Oil & Gas ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Oil & Gas Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXN.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the oil and gas sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising either the oil & gas producers sector or the oil equipment, services & distribution sector according to the Industry Classification Benchmark (“ICB”). The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) companies engaged in the exploration for and drilling, production, refining and supply of oil and gas products; (ii) integrated oil and gas companies engaged in the exploration for, and drilling, production, refining, distribution and retail sales of, oil and gas products; (iii) suppliers of equipment and services to oil fields and offshore platforms, such as drilling, exploration, seismic-information services and platform construction; and (iv) operators of pipelines carrying oil, gas or other forms of fuel.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	73.19%	7.10%	7.30%	40.89%	47.58%
Market Price	73.07%	7.10%	7.30%	40.90%	47.59%
Index Performance
Nasdaq US Smart Oil & Gas Index^TM	74.64%	7.83%	8.01%	45.80%	53.10%
NASDAQ US Benchmark Energy Index	59.92%	6.54%	7.03%	37.27%	45.54%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 73.19% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index generated a return of 12.05%, and the NASDAQ US Benchmark Energy Index (the “Benchmark”) generated a return of 59.92%. The Oil, Gas & Consumable Fuels industry received a 95.0% allocation in the Fund and provided the Fund’s largest contribution to return at 69.9%. No industry made a negative contribution to the Fund’s return for the period. On a relative basis, the Fund outperformed the Benchmark. The largest source of outperformance came from investments in the Oil, Gas & Consumable Fuels industry which generated a 9.2% contribution to the Fund’s relative return versus the Benchmark. Each of the industries within the Fund earned outperformance for the Fund versus the Benchmark, with the exception of the Metals & Mining industry which generated a -0.2% return versus the Benchmark

Nasdaq^® and Nasdaq US Smart Oil & Gas Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Oil & Gas ETF (FTXN) (Continued)

Sector Allocation	% of Total Investments
Energy	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Chevron Corp.	7.2%
Marathon Oil Corp.	6.4
Williams (The) Cos., Inc.	6.1
ConocoPhillips	6.0
Devon Energy Corp.	5.7
Occidental Petroleum Corp.	4.5
APA Corp.	4.1
Targa Resources Corp.	4.0
Chesapeake Energy Corp.	3.9
Marathon Petroleum Corp.	3.8
Total	51.7%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

The First Trust Nasdaq Pharmaceuticals ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Pharmaceuticals Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXH.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the pharmaceutical sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the pharmaceuticals sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes vaccine producers and manufacturers of prescription or over-the-counter drugs.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	5.39%	7.33%	6.40%	42.44%	40.87%
Market Price	5.15%	7.29%	6.36%	42.18%	40.61%
Index Performance
Nasdaq US Smart Pharmaceuticals Index^TM	6.13%	8.04%	7.10%	47.18%	46.06%
NASDAQ US Benchmark Pharmaceuticals Index	23.69%	14.04%	13.41%	92.89%	100.43%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 5.39% during the period covered by this report. During the same period, the NASDAQ US Benchmark Index generated a return of 12.05%, and the NASDAQ US Benchmark Pharmaceuticals Index (the “Benchmark”) generated a return of 23.69%. The Pharmaceuticals industry received an allocation of 66.0% in the Fund and 71.0% in the Benchmark. Other represented industries were Biotechnology, Health Care Equipment & Supplies, and Health Care Providers & Services. The Pharmaceuticals industry was the primary driver of the Fund’s return, with a contribution to overall Fund return of 4.4%. The only sector with a negative contribution to the Fund’s return was the Health Care Equipment & Supplies sector with a -0.3% contribution to the Fund’s return. On a relative basis, the Fund underperformed the Benchmark. Each of the sectors in the Fund caused the Fund to underperform the Benchmark. The Fund’s investments in the Pharmaceuticals industry generated -11.0% of relative underperformance for the Fund versus the Benchmark, largely resulting from selection effect.

Nasdaq^® and Nasdaq US Smart Pharmaceuticals Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Pharmaceuticals ETF (FTXH) (Continued)

Sector Allocation	% of Total Investments
Health Care	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
AbbVie, Inc.	8.3%
Johnson & Johnson	8.2
Bristol-Myers Squibb Co.	8.1
Cardinal Health, Inc.	8.0
Gilead Sciences, Inc.	7.5
Ironwood Pharmaceuticals, Inc.	4.4
Eli Lilly & Co.	4.4
Vertex Pharmaceuticals, Inc.	4.3
Pfizer, Inc.	4.2
Merck & Co., Inc.	4.1
Total	61.5%

Frequency Distribution of Discounts and Premiums

Page 11

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Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network E-Commerce ETF (ISHP)

The First Trust S-Network E-Commerce ETF (the “Fund”), formerly the First Trust Nasdaq Retail ETF, seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the S-Network Global E-Commerce Index^TM(the “Index”). The Fund lists and principally trades its shares on The Nasdaq, Inc. under the symbol “ISHP.” The Fund will normally invest at least 90% of its net assets (plus any borrowings for investment purposes) in the common stocks and depository receipts that comprise the Index.

The Index seeks to provide exposure to companies with securities listed on recognized global securities exchanges that are principally engaged in the global e-commerce industry, including the online retail, online marketplace, content navigation and e-commerce infrastructure business segments. To be eligible for inclusion in the Index, a security must be issued by a company principally engaged in one of the four following business segments comprising the global e-commerce industry: (1) content navigation; (2) online retail; (3) online marketplace; and (4) e-commerce infrastructure. The Index is owned and is developed, maintained and sponsored by S-Network Global Indexes, Inc. (the “Index Provider”).

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	-0.94%	10.62%	9.47%	65.62%	64.88%
Market Price	-1.13%	10.57%	9.47%	65.24%	64.88%
Index Performance
S-Network Global E-Commerce Index⁽¹⁾⁽²⁾	N/A	N/A	N/A	N/A	N/A
MSCI ACWI Index⁽³⁾	7.28%	11.64%	12.33%	73.43%	90.11%
Nasdaq US Smart Retail Index	9.07%	13.35%	11.98%	87.08%	86.85%
NASDAQ US Benchmark Retail Index	6.35%	19.45%	18.87%	143.19%	159.93%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -0.94% during the period covered by this report. During the same period, the MSCI ACWI Index (the “Benchmark”) generated a return of 7.28%. The Fund had a 65.6% exposure to the Consumer Discretionary sector, which caused a -1.9% contribution to the Fund’s total return, the most exposure but also greatest negative contribution to the Fund’s return of any sector. The Consumer Staples sector contributed 3.1% to the Fund’s total return. On a relative basis, the Fund underperformed the Benchmark. The greatest source of underperformance were the investments in the Consumer Discretionary sector which caused -5.9% of underperformance for the Fund versus the Benchmark. The greatest source of relative outperformance came from the Consumer Staples sector which caused 2.2% of underperformance.

⁽¹⁾

On January 26, 2022, the Fund’s underlying index changed from the NASDAQ US Smart Retail Index to the S-Network Global E-Commerce Index. Therefore, performance and historical returns shown for the periods prior to January 26, 2022, are not necessarily indicative of the performance of the Fund, based on its current Index, would have generated.

⁽²⁾	Because the Fund’s new underlying Index had an inception date of April 30, 2021, performance data is not available for all the periods shown in the table for the Index because performance data does not exist for some of the entire periods.

⁽³⁾	The MSCI ACWI Index will serve as the Fund’s new primary benchmark index. The Fund’s investment advisor has determined that the MSCI ACWI Index provides a more appropriate comparison to Fund returns.

S-Network and S-Network Global E-Commerce Index^TM are service marks of S-Network Global Indexes, Inc. and have been licensed for use by First Trust Advisors L.P. The Fund is not issued, sponsored, endorsed, sold or promoted by S-Network Global Indexes, Inc. or its affiliates (collectively, “S-Network”). S-Network makes no representation or warranty, express or implied, to the purchasers or owners of the Fund or any member of the public regarding the advisability of investing in securities generally or in the Fund particularly or the ability of the Index to track general market performance.

Page 12

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network E-Commerce ETF (ISHP) (Continued)

Sector Allocation	% of Total Investments
Consumer Discretionary	39.0%
Communication Services	22.3
Industrials	18.6
Information Technology	9.9
Real Estate	5.0
Consumer Staples	3.4
Financials	1.8
Total	100.0%

Top Ten Holdings	% of Total Investments
ZoomInfo Technologies, Inc.	2.3%
Union Pacific Corp.	2.2
Canadian National Railway Co.	2.2
Lululemon Athletica, Inc.	2.2
Expedia Group, Inc.	2.1
MercadoLibre, Inc.	2.1
Prologis, Inc.	2.1
Airbnb, Inc., Class A	2.1
Walmart, Inc.	2.0
CSX Corp.	2.0
Total	21.3%

Frequency Distribution of Discounts and Premiums

Page 13

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Semiconductor ETF (FTXL)

The First Trust Nasdaq Semiconductor ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Semiconductor Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXL.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the semiconductor sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the semiconductors sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes producers and distributors of semiconductors and other integrated chips, including other products related to the semiconductor industry, such as semiconductor capital equipment and motherboards.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	8.46%	23.59%	26.28%	188.29%	263.03%
Market Price	8.55%	23.61%	26.31%	188.55%	263.49%
Index Performance
Nasdaq US Smart Semiconductor Index^TM	9.16%	24.38%	27.10%	197.65%	276.32%
NASDAQ US Benchmark Semiconductors Index	26.06%	28.11%	28.49%	245.06%	299.60%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 8.46% during the period covered by this report. During the same period, the NASDAQ US Benchmark Semiconductors Index (the “Benchmark”) generated a return of 26.06%. The Fund allocated 96.6% to the Semiconductors & Semiconductor Equipment industry while the Benchmark allocated 98.8% to the same industry. The Fund’s largest sub-industry allocation during the period was the 73.5% weight to the Semiconductors sub-industry. This sub-industry also made the largest contribution to the Fund’s return at 9.6% during the period. The only negative contribution to Fund was the -1.1% from the Electronic Equipment Instruments & Components industry. On a relative basis, the Fund underperformed the Benchmark. The largest source of this underperformance came from investments in the Semiconductor Equipment sub-industry where the Fund earned underperformance against the Benchmark of -4.9%. Furthermore, the Fund underperformed the Benchmark across all industries and both of the Semiconductors & Semiconductor Equipment sub-industries during the period.

Nasdaq^® and Nasdaq US Smart Semiconductor Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Semiconductor ETF (FTXL) (Continued)

Sector Allocation	% of Total Investments
Information Technology	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Broadcom, Inc.	8.6%
Intel Corp.	8.3
Texas Instruments, Inc.	6.8
Micron Technology, Inc.	5.7
QUALCOMM, Inc.	5.3
II-VI, Inc.	4.2
ON Semiconductor Corp.	4.0
KLA Corp.	3.6
Analog Devices, Inc.	3.5
Skyworks Solutions, Inc.	3.1
Total	53.1%

Frequency Distribution of Discounts and Premiums

Page 15

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Transportation ETF (FTXR)

The First Trust Nasdaq Transportation ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Transportation Index^TM (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXR.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the transportation sector that have been selected based upon their liquidity and weighted based upon their cumulative score on three investing factors: volatility, value and growth. The Index’s initial selection universe consists of the component securities of the NASDAQ US Benchmark Index that have been classified as comprising the industrial transportation sector, the automobiles & parts sector or the airlines sub-sector according to the Industry Classification Benchmark. The NASDAQ US Benchmark Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) operators of mail and package delivery services; (ii) providers of on-water transportation for commercial markets; (iii) providers of industrial railway transportation and railway lines; (iv) companies that manage airports, train depots, roads, bridges, tunnels, ports, and providers of logistic services to shippers of goods; (v) companies that provide commercial trucking services; (vi) makers of motorcycles and passenger vehicles; (vii) manufacturers and distributors of new and replacement parts for motorcycles and automobiles; (viii) manufacturers, distributors and retreaders of automobile, truck and motorcycle tires; and (ix) companies providing primarily passenger air transport.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22	5 Years Ended 3/31/22	Inception (9/20/16) to 3/31/22
Fund Performance
NAV	-0.53%	8.43%	10.35%	49.86%	72.30%
Market Price	-0.56%	8.40%	10.35%	49.71%	72.35%
Index Performance
Nasdaq US Smart Transportation Index^TM	-0.46%	8.96%	10.90%	53.55%	77.15%
NASDAQ US Benchmark Industrial Transportation Index	13.21%	18.20%	19.52%	130.69%	167.93%
NASDAQ US Benchmark Index	12.05%	15.53%	16.29%	105.85%	130.25%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -0.53% during the period covered by this report. During the same period, the NASDAQ US Benchmark Industrial Transportation Index (the “Benchmark”) generated a return of 13.21%. The Road & Rail industry’s 27.2% allocation was the Fund’s largest weight during the period. This industry also made the largest contribution to the Fund’s return with 4.1% for the period. The largest negative contribution to the Fund’s return was the -3.0% from the Specialty Retail industry. On a relative basis, the Fund underperformed the Benchmark. The largest source of underperformance came from the Airlines industry which generated a -4.5% drag for the Fund versus the Benchmark for the period. None of the invested industries earned outperformance for the Fund versus the Benchmark.

Nasdaq^® and Nasdaq US Smart Transportation Index^TM are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

Page 16

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Transportation ETF (FTXR) (Continued)

Sector Allocation	% of Total Long-Term Investments
Industrials	75.2%
Consumer Discretionary	24.8
Total	100.0%

Top Ten Holdings	% of Total Long-Term Investments
Union Pacific Corp.	8.7%
CSX Corp.	8.2
JB Hunt Transport Services, Inc.	7.7
PACCAR, Inc.	7.5
Ford Motor Co.	6.6
CH Robinson Worldwide, Inc.	4.4
Norfolk Southern Corp.	4.3
United Rentals, Inc.	4.3
FedEx Corp.	4.1
United Parcel Service, Inc., Class B	4.0
Total	59.8%

Frequency Distribution of Discounts and Premiums

Page 17

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network Streaming & Gaming ETF (BNGE)

The First Trust S-Network Streaming & Gaming ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an index called the S-Network Streaming & Gaming Index (the “Index”). The Fund lists and principally trades its shares on The NYSE Arca, Inc. under the ticker symbol “BNGE.” The Fund will normally invest at least 80% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Fund, using an indexing investment approach, attempts to replicate, before fees and expenses, the performance of the Index. The Index is developed, maintained and sponsored by S-Network Global Indexes, Inc. (the “Index Provider”). The Index Provider retains the right at any time, upon prior written notice, to modify the Index methodology.

Performance
		Cumulative Total Returns
		Inception (1/25/22) to 3/31/22
Fund Performance
NAV		-4.81%
Market Price		-4.28%
Index Performance
S-Network Streaming & Gaming Index		-4.13%
MSCI ACWI Index		1.98%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -4.81% from the Fund’s inception date of January 25, 2022 through March 31, 2022. During the same period, the MSCI ACWI Index (the “Benchmark”) generated a return of 1.98%. The United States was the highest weighted country during the period with an allocation of 54.6%. However, the country with the largest contribution to the Fund’s return was Japan with a contribution of 0.2%. Investments in the Cayman Islands contributed -3.0% to the Fund’s total return, the worst of any country. The total currency effect to the Fund from the Fund’s inception date through March 31, 2022 was less than -0.1%. On a relative basis, the Fund underperformed the Benchmark. The greatest degree of underperformance came from investments in the Cayman Islands. These investments generated a -2.9% drag on the Fund relative to the Benchmark. The greatest degree of outperformance came from investments in Japan which contributed 0.3% to the Fund’s outperformance versus the Benchmark.

S-Network and S-Network Streaming & Gaming Index are service marks of S-Network Global Indexes, Inc. and have been licensed for use by First Trust Advisors L.P. The Fund is not issued, sponsored, endorsed, sold or promoted by S-Network Global Indexes, Inc. or its affiliates (collectively, “S-Network”). S-Network makes no representation or warranty, express or implied, to the purchasers or owners of the Fund or any member of the public regarding the advisability of investing in securities generally or in the Fund particularly or the ability of the Index to track general market performance.

Page 18

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network Streaming & Gaming ETF (BNGE) (Continued)

Sector Allocation	% of Total Investments
Communication Services	56.3%
Consumer Discretionary	26.3
Information Technology	17.4
Total	100.0%

Top Ten Holdings	% of Total Investments
Activision Blizzard, Inc.	6.5%
NVIDIA Corp.	5.3
Nintendo Co., Ltd.	5.2
Electronic Arts, Inc.	5.1
Intel Corp.	4.7
NetEase, Inc., ADR	4.6
Walt Disney (The) Co.	4.6
Advanced Micro Devices, Inc.	4.3
Sony Group Corp.	4.3
Tencent Holdings Ltd.	3.9
Total	48.5%

Frequency Distribution of Discounts and Premiums

Page 19

Table of Contents

Notes to Fund Performance Overview (Unaudited)

Total returns for the periods since inception are calculated from the inception date of each Fund. “Average Annual Total Returns” represent the average annual change in value of an investment over the periods indicated. “Cumulative Total Returns” represent the total change in value of an investment over the periods indicated.

Each Fund’s per share net asset value (“NAV”) is the value of one share of the Fund and is computed by dividing the value of all assets of the Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of outstanding shares. The price used to calculate market return (“Market Price”) is determined by using the midpoint of the national best bid and offer price (“NBBO”) as of the time that the Fund’s NAV is calculated. Under SEC rules, the NBBO consists of the highest displayed buy and lowest sell prices among the various exchanges trading the Fund at the time the Fund’s NAV is calculated. Prior to January 1, 2019, the price used was the midpoint between the highest bid and the lowest offer on the stock exchange on which shares of the Fund were listed for trading as of the time that the Fund’s NAV was calculated. Since shares of each Fund did not trade in the secondary market until after the Fund’s inception, for the period from inception to the first day of secondary market trading in shares of the Fund, the NAV of each Fund is used as a proxy for the secondary market trading price to calculate market returns. NAV and market returns assume that all distributions have been reinvested in each Fund at NAV and Market Price, respectively.

An index is a statistical composite that tracks a specified financial market or sector. Unlike each Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by each Fund. These expenses negatively impact the performance of each Fund. Also, market returns do not include brokerage commissions that may be payable on secondary market transactions. If brokerage commissions were included, market returns would be lower. The total returns presented reflect the reinvestment of dividends on securities in the indices. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. The investment return and principal value of shares of each Fund will vary with changes in market conditions. Shares of each Fund may be worth more or less than their original cost when they are redeemed or sold in the market. Each Fund’s past performance is no guarantee of future performance.

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First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses

March 31, 2022 (Unaudited)

As a shareholder of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust S-Network E-Commerce ETF, First Trust Nasdaq Semiconductor ETF, First Trust Nasdaq Transportation ETF or First Trust S-Network Streaming & Gaming ETF (each a “Fund” and collectively, the “Funds”), you incur two types of costs: (1) transaction costs; and (2) ongoing costs, including management fees, distribution and/or service (12b-1) fees, if any, and other Fund expenses. This Example is intended to help you understand your ongoing costs of investing in the Funds and to compare these costs with the ongoing costs of investing in other funds.

The Example is based on an investment of $1,000 invested at the beginning of the period (or since inception) and held through the six-month (or shorter) period ended March 31, 2022.

Actual Expenses

The first line in the following table provides information about actual account values and actual expenses. You may use the information in this line, together with the amount you invested, to estimate the expenses that you paid over the period. Simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number in the first line under the heading entitled “Expenses Paid During the Six-Month Period” to estimate the expenses you paid on your account during this six-month (or shorter) period.

Hypothetical Example for Comparison Purposes

The second line in the following table provides information about hypothetical account values and hypothetical expenses based on each Fund’s actual expense ratio and an assumed rate of return of 5% per year before expenses, which is not each Fund’s actual return. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in the Funds and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs such as brokerage commissions. Therefore, the second line in the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

	Beginning Account Value October 1, 2021	Ending Account Value March 31, 2022	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
First Trust Nasdaq Bank ETF (FTXO)
Actual	$1,000.00	$983.60	0.60%	$2.97
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Food & Beverage ETF (FTXG)
Actual	$1,000.00	$1,130.40	0.60%	$3.19
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Oil & Gas ETF (FTXN)
Actual	$1,000.00	$1,402.60	0.60%	$3.59
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Pharmaceuticals ETF (FTXH)
Actual	$1,000.00	$1,050.90	0.60%	$3.07
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust S-Network E-Commerce ETF (ISHP)
Actual	$1,000.00	$911.90	0.60%	$2.86
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Semiconductor ETF (FTXL)
Actual	$1,000.00	$1,041.60	0.60%	$3.05
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02

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Table of Contents

First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses (Continued)

March 31, 2022 (Unaudited)

	Beginning Account Value October 1, 2021	Ending Account Value March 31, 2022	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
First Trust Nasdaq Transportation ETF (FTXR)
Actual	$1,000.00	$1,056.00	0.60%	$3.08
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02

	Beginning Account Value January 25, 2022	Ending Account Value March 31, 2022	Annualized Expense Ratio Based on the Number of Days In the Period	Expenses Paid During the Period January 25, 2022 (b) to March 31, 2022 (c)
First Trust S-Network Streaming & Gaming ETF (BNGE)
Actual	$1,000.00	$951.90	0.70%	$1.24
Hypothetical (5% return before expenses)	$1,000.00	$1,021.44	0.70%	$3.53

(a)	Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (October 1, 2021 through March 31, 2022), multiplied by 182/365 (to reflect the six-month period).
(b)	Inception date.
(c)	Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (January 25, 2022 through March 31, 2022), multiplied by 66/365 (to reflect the six-month period). Hypothetical expenses are assumed for the most recent six-month period.

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Table of Contents

First Trust Nasdaq Bank ETF (FTXO)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.8%
	Banks – 95.0%
357,312	Bank of America Corp.	$14,728,401
266,640	Citigroup, Inc.	14,238,576
602,566	Citizens Financial Group, Inc.	27,314,317
165,390	Comerica, Inc.	14,956,218
100,481	Cullen/Frost Bankers, Inc.	13,907,575
39,553	East West Bancorp, Inc.	3,125,478
330,127	Fifth Third Bancorp	14,208,666
4,391	First Citizens BancShares, Inc., Class A	2,922,649
19,992	First Republic Bank	3,240,703
223,164	Huntington Bancshares, Inc.	3,262,658
111,374	JPMorgan Chase & Co.	15,182,504
1,259,931	KeyCorp	28,197,256
86,666	M&T Bank Corp.	14,689,887
863,961	Old National Bancorp	14,151,681
34,263	Pinnacle Financial Partners, Inc.	3,154,937
79,265	PNC Financial Services Group (The), Inc.	14,620,429
343,891	Popular, Inc.	28,109,650
652,885	Regions Financial Corp.	14,533,220
10,042	Signature Bank	2,947,226
27,044	Silvergate Capital Corp., Class A (a)	4,072,015
5,715	SVB Financial Group (a)	3,197,257
299,968	Synovus Financial Corp.	14,698,432
55,664	Truist Financial Corp.	3,156,149
132,133	US Bancorp	7,022,869
57,522	Webster Financial Corp.	3,228,135
591,841	Wells Fargo & Co.	28,680,615
36,948	Western Alliance Bancorp	3,060,033
445,569	Zions Bancorp N.A.	29,211,504
		343,819,040
	Consumer Finance – 3.9%
127,942	Discover Financial Services	14,097,929
	Thrifts & Mortgage Finance – 0.9%
300,127	New York Community Bancorp, Inc.	3,217,361
	Total Investments – 99.8%	361,134,330
	(Cost $366,326,636)
	Net Other Assets and Liabilities – 0.2%	802,259
	Net Assets – 100.0%	$361,936,589

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 361,134,330	$ 361,134,330	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

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Table of Contents

First Trust Nasdaq Food & Beverage ETF (FTXG)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.9%
	Beverages – 18.7%
328	Boston Beer (The) Co., Inc., Class A (a)	$127,418
1,928	Brown-Forman Corp., Class B	129,215
1,969	Celsius Holdings, Inc. (a)	108,649
6,798	Coca-Cola (The) Co.	421,476
583	Constellation Brands, Inc., Class A	134,276
10,941	Keurig Dr. Pepper, Inc.	414,664
2,410	Molson Coors Beverage Co., Class B	128,646
1,490	Monster Beverage Corp. (a)	119,051
2,584	PepsiCo, Inc.	432,510
		2,015,905
	Chemicals – 4.3%
8,131	Corteva, Inc.	467,370
	Food & Staples Retailing – 1.1%
3,218	US Foods Holding Corp. (a)	121,093
	Food Products – 74.8%
10,785	Archer-Daniels-Midland Co.	973,454
2,689	Beyond Meat, Inc. (a)	129,906
8,093	Bunge Ltd.	896,785
9,408	Campbell Soup Co.	419,315
19,043	Conagra Brands, Inc.	639,273
1,736	Darling Ingredients, Inc. (a)	139,540
1,321	Freshpet, Inc. (a)	135,587
6,274	General Mills, Inc.	424,875
3,264	Hershey (The) Co.	707,080
2,640	Hormel Foods Corp.	136,066
19,640	Hostess Brands, Inc. (a)	430,902
3,139	JM Smucker (The) Co.	425,052
6,616	Kellogg Co.	426,666
10,786	Kraft Heinz (The) Co.	424,860
1,894	Lamb Weston Holdings, Inc.	113,470
4,446	McCormick & Co., Inc.	443,711
6,461	Mondelez International, Inc., Class A	405,622
9,131	Tyson Foods, Inc., Class A	818,411
		8,090,575
	Personal Products – 1.0%
3,536	Herbalife Nutrition Ltd. (a)	107,353
	Total Investments – 99.9%	10,802,296
	(Cost $10,007,726)
	Net Other Assets and Liabilities – 0.1%	8,187
	Net Assets – 100.0%	$10,810,483

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 10,802,296	$ 10,802,296	$ —	$ —

*	See Portfolio of Investments for industry breakout.

Page 24

See Notes to Financial Statements

Table of Contents

First Trust Nasdaq Oil & Gas ETF (FTXN)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.8%
	Energy Equipment & Services – 2.9%
87,637	Baker Hughes Co.	$3,190,863
120,258	ChampionX Corp. (a)	2,943,916
401,179	Halliburton Co.	15,192,649
71,067	Helmerich & Payne, Inc.	3,040,246
150,134	NOV, Inc.	2,944,128
65,613	Schlumberger N.V.	2,710,473
727,335	Transocean Ltd. (a)	3,323,921
		33,346,196
	Oil, Gas & Consumable Fuels – 96.9%
256,449	Antero Midstream Corp.	2,787,601
112,284	Antero Resources Corp. (a)	3,428,030
1,122,776	APA Corp.	46,404,332
45,682	Callon Petroleum Co. (a)	2,698,893
1,180,397	Centennial Resource Development, Inc./DE, Class A (a)	9,525,804
220,934	Cheniere Energy, Inc.	30,632,499
517,860	Chesapeake Energy Corp.	45,053,820
506,120	Chevron Corp.	82,411,520
51,015	Civitas Resources, Inc.	3,046,106
157,573	CNX Resources Corp. (a)	3,264,913
686,332	ConocoPhillips	68,633,200
110,365	Coterra Energy, Inc.	2,976,544
35,435	Denbury, Inc. (a)	2,784,128
1,110,585	Devon Energy Corp.	65,668,891
179,839	Diamondback Energy, Inc.	24,652,330
348,103	EOG Resources, Inc.	41,504,321
111,272	EQT Corp.	3,828,869
401,682	Equitrans Midstream Corp.	3,390,196
417,625	Exxon Mobil Corp.	34,491,649
25,481	Hess Corp.	2,727,486
84,554	HF Sinclair Corp. (a)	3,369,477
2,299,107	Kinder Morgan, Inc.	43,476,113
6,049,057	Kosmos Energy Ltd. (a)	43,492,720
33,629	Laredo Petroleum, Inc. (a)	2,661,399
2,898,627	Marathon Oil Corp.	72,784,524
513,731	Marathon Petroleum Corp.	43,924,000
806,544	Matador Resources, Co.	42,730,701
674,957	Murphy Oil Corp.	27,261,513
914,808	Occidental Petroleum Corp.	51,906,206
384,335	ONEOK, Inc.	27,145,581
421,658	Ovintiv, Inc.	22,799,048
154,917	PBF Energy, Inc., Class A (a)	3,775,327
368,671	PDC Energy, Inc.	26,795,008
30,567	Phillips 66	2,640,683
148,801	Pioneer Natural Resources Co.	37,204,714
112,194	Range Resources Corp. (a)	3,408,454
181,172	SM Energy Co.	7,056,649
515,987	Southwestern Energy Co. (a)	3,699,627
611,969	Targa Resources Corp.	46,185,300
675,796	Tellurian, Inc. (a)	3,581,719
30,828	Valero Energy Corp.	3,130,275

Shares	Description	Value

	Oil, Gas & Consumable Fuels (Continued)
534,816	Whiting Petroleum Corp.	$43,592,852
2,084,394	Williams (The) Cos., Inc.	69,639,604
		1,112,172,626
	Total Investments – 99.8%	1,145,518,822
	(Cost $980,129,753)
	Net Other Assets and Liabilities – 0.2%	2,112,150
	Net Assets – 100.0%	$1,147,630,972

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 1,145,518,822	$ 1,145,518,822	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 25

Table of Contents

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.9%
	Biotechnology – 40.8%
8,893	AbbVie, Inc.	$1,441,644
9,912	Alkermes PLC (a)	260,785
2,901	Amgen, Inc.	701,520
3,154	BioMarin Pharmaceutical, Inc. (a)	243,173
4,069	Blueprint Medicines Corp. (a)	259,928
5,955	Emergent BioSolutions, Inc. (a)	244,512
21,757	Gilead Sciences, Inc.	1,293,454
2,703	Horizon Therapeutics PLC (a)	284,383
7,382	Ionis Pharmaceuticals, Inc. (a)	273,429
61,066	Ironwood Pharmaceuticals, Inc. (a)	768,210
1,912	Seagen, Inc. (a)	275,424
1,483	United Therapeutics Corp. (a)	266,065
2,857	Vertex Pharmaceuticals, Inc. (a)	745,591
		7,058,118
	Health Care Providers & Services – 8.0%
24,331	Cardinal Health, Inc.	1,379,568
	Pharmaceuticals – 51.1%
19,137	Bristol-Myers Squibb Co.	1,397,575
2,415	Catalent, Inc. (a)	267,823
11,054	Corcept Therapeutics, Inc. (a)	248,936
8,673	Elanco Animal Health, Inc. (a)	226,279
2,629	Eli Lilly & Co.	752,867
79,228	Endo International PLC (a)	183,017
1,793	Jazz Pharmaceuticals PLC (a)	279,116
7,985	Johnson & Johnson	1,415,182
8,580	Merck & Co., Inc.	703,989
6,601	Organon & Co.	230,573
3,695	Pacira BioSciences, Inc. (a)	282,002
6,937	Perrigo Co. PLC	266,589
13,998	Pfizer, Inc.	724,676
11,038	Prestige Consumer Healthcare, Inc. (a)	584,352
59,679	Viatris, Inc.	649,307
3,393	Zoetis, Inc.	639,886
		8,852,169
	Total Investments – 99.9%	17,289,855
	(Cost $15,705,794)
	Net Other Assets and Liabilities – 0.1%	21,475
	Net Assets – 100.0%	$17,311,330

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 17,289,855	$ 17,289,855	$ —	$ —

*	See Portfolio of Investments for industry breakout.

Page 26

See Notes to Financial Statements

Table of Contents

First Trust S-Network E-Commerce ETF (ISHP)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 97.7%
	Air Freight & Logistics – 5.3%
5,896	Deutsche Post AG (a)	$281,545
1,436	FedEx Corp.	332,276
1,758	United Parcel Service, Inc., Class B	377,021
		990,842
	Commercial Services & Supplies – 1.8%
2,672	Copart, Inc. (b)	335,256
	Entertainment – 1.3%
2,051	Sea Ltd., ADR (b)	245,689
	Food & Staples Retailing – 3.4%
5,564	HelloFresh SE (a) (b)	249,733
2,547	Walmart, Inc.	379,299
		629,032
	Hotels, Restaurants & Leisure – 6.0%
2,231	Airbnb, Inc., Class A (b)	383,196
148	Booking Holdings, Inc. (b)	347,571
2,000	Expedia Group, Inc. (b)	391,340
		1,122,107
	Interactive Media & Services – 21.0%
27,679	Adevinta ASA (a) (b)	252,687
134	Alphabet, Inc., Class A (b)	372,701
38,202	Auto Trader Group PLC (a) (c) (d)	315,368
2,430	Baidu, Inc., ADR (b)	321,489
2,864	IAC/InterActiveCorp (b)	287,202
1,132	Meta Platforms, Inc., Class A (b)	251,712
1,255	NAVER Corp. (a)	348,801
11,235	Pinterest, Inc., Class A (b)	276,493
3,208	REA Group Ltd. (a)	321,600
9,651	Snap, Inc., Class A (b)	347,339
9,568	Twitter, Inc. (b)	370,186
6,796	Yandex N.V., Class A (a) (b) (e) (f)	8,342
7,025	ZoomInfo Technologies, Inc. (b)	419,674
		3,893,594
	Internet & Direct Marketing Retail – 23.9%
2,819	Alibaba Group Holding Ltd., ADR (b)	306,707
113	Amazon.com, Inc. (b)	368,374
8,034	Chewy, Inc., Class A (b)	327,626
16,518	Coupang, Inc. (b)	292,038
3,863	Delivery Hero SE (a) (b) (c) (d)	168,364
5,852	eBay, Inc.	335,085
2,221	Etsy, Inc. (b)	276,026
13,899	Farfetch Ltd., Class A (b)	210,153

Shares	Description	Value

	Internet & Direct Marketing Retail (Continued)
9,775	JD.com, Inc, Class A (a) (b)	$277,756
12,635	Meituan, Class B (a) (b) (c) (d)	239,357
329	MercadoLibre, Inc. (b)	391,339
6,426	Pinduoduo, Inc., ADR (b)	257,747
4,150	Prosus N.V. (a)	223,801
36,900	Rakuten Group, Inc. (a)	290,135
2,178	Wayfair, Inc., Class A (b)	241,279
4,805	Zalando SE (a) (b) (c) (d)	243,297
		4,449,084
	IT Services – 8.2%
169	Adyen N.V. (a) (b) (c) (d)	334,737
2,706	Block, Inc. (b)	366,934
3,401	Fiserv, Inc. (b)	344,861
2,044	PayPal Holdings, Inc. (b)	236,389
348	Shopify, Inc., Class A (b)	235,234
		1,518,155
	Leisure Products – 1.6%
11,521	Peloton Interactive, Inc., Class A (b)	304,385
	Marine – 1.6%
97	AP Moller - Maersk A.S., Class B (a)	291,481
	Professional Services – 1.8%
5,004	Costar Group, Inc. (b)	333,316
	Real Estate Management & Development – 2.9%
17,564	KE Holdings, Inc., ADR (b)	217,267
6,545	Zillow Group, Inc., Class C (b)	322,603
		539,870
	Road & Rail – 8.1%
3,020	Canadian National Railway Co.	405,115
10,082	CSX Corp.	377,571
8,639	Uber Technologies, Inc. (b)	308,239
1,494	Union Pacific Corp.	408,176
		1,499,101
	Software – 1.7%
669	Intuit, Inc.	321,682
	Specialty Retail – 5.2%
3,609	Best Buy Co., Inc.	328,058
2,274	Carvana Co. (b)	271,266
2,488	Williams-Sonoma, Inc.	360,760
		960,084
	Textiles, Apparel & Luxury Goods – 2.2%
1,100	Lululemon Athletica, Inc. (b)	401,753

See Notes to Financial Statements

Page 27

Table of Contents

First Trust S-Network E-Commerce ETF (ISHP)

Portfolio of Investments (Continued)

March 31, 2022

Shares	Description	Value
COMMON STOCKS (Continued)
	Thrifts & Mortgage Finance – 1.7%
28,907	Rocket Cos, Inc., Class A	$321,446
	Total Common Stocks	18,156,877
	(Cost $20,022,964)
REAL ESTATE INVESTMENT TRUSTS – 2.1%
	Equity Real Estate Investment Trusts – 2.1%
2,416	Prologis, Inc.	390,136
	(Cost $372,076)
	Total Investments – 99.8%	18,547,013
	(Cost $20,395,040)
	Net Other Assets and Liabilities – 0.2%	39,389
	Net Assets – 100.0%	$18,586,402

(a)	This security is fair valued by the Advisor’s Pricing Committee in accordance with procedures adopted by the Trust’s Board of Trustees and in accordance with provisions of the Investment Company Act of 1940, as amended. At March 31, 2022, securities noted as such are valued at $3,847,004 or 20.7% of net assets. Certain of these securities are fair valued using a factor provided by a third-party pricing service due to the change in value between the foreign markets’ close and the New York Stock Exchange close exceeding a certain threshold. On days when this threshold is not exceeded, these securities are typically valued at the last sale price on the exchange on which they are principally traded.
(b)	Non-income producing security.
(c)	This security, sold within the terms of a private placement memorandum, is exempt from registration upon resale under Rule 144A of the Securities Act of 1933, as amended (the “1933 Act”), and may be resold in transactions exempt from registration, normally to qualified institutional buyers. Pursuant to procedures adopted by the Trust’s Board of Trustees, this security has been determined to be liquid by First Trust Advisors L.P. (the “Advisor”). Although market instability can result in periods of increased overall market illiquidity, liquidity for each security is determined based on security specific factors and assumptions, which require subjective judgment. At March 31, 2022, securities noted as such amounted to $1,301,123 or 7.0% of net assets.
(d)	This security may be resold to qualified foreign investors and foreign institutional buyers under Regulation S of the 1933 Act.
(e)	Pursuant to procedures adopted by the Trust’s Board of Trustees, this security has been determined to be illiquid by the Advisor.
(f)	This security’s value was determined using significant unobservable inputs (see Note 2A – Portfolio Valuation in the Notes to Financial Statements).

ADR	American Depositary Receipt

Currency Exposure Diversification	% of Total Investments
United States Dollar	77.1%
Euro	8.1
Hong Kong Dollar	2.8
Canadian Dollar	2.2
South Korean Won	1.9
Australian Dollar	1.7
British Pound Sterling	1.7
Danish Krone	1.6
Japanese Yen	1.6
Norwegian Krone	1.3
Total	100.0%

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks:
Air Freight & Logistics	$ 990,842	$ 709,297	$ 281,545	$ —
Food & Staples Retailing	629,032	379,299	249,733	—
Interactive Media & Services	3,893,594	2,646,796	1,238,456	8,342
Internet & Direct Marketing Retail	4,449,084	3,006,374	1,442,710	—
IT Services	1,518,155	1,183,418	334,737	—
Marine	291,481	—	291,481	—
Other industry categories*	6,384,689	6,384,689	—	—
Real Estate Investment Trusts*	390,136	390,136	—	—
Total Investments	$ 18,547,013	$ 14,700,009	$ 3,838,662	$ 8,342

*	See Portfolio of Investments for industry breakout.

Page 28

See Notes to Financial Statements

Table of Contents

First Trust Nasdaq Semiconductor ETF (FTXL)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.8%
	Electronic Equipment, Instruments & Components – 6.2%
62,562	II-VI, Inc. (a)	$4,535,119
19,734	IPG Photonics Corp. (a)	2,166,004
		6,701,123
	Semiconductors & Semiconductor Equipment – 93.6%
20,856	Advanced Micro Devices, Inc. (a)	2,280,395
18,412	Ambarella, Inc. (a)	1,931,787
22,642	Analog Devices, Inc.	3,740,006
19,168	Applied Materials, Inc.	2,526,342
29,391	Azenta, Inc.	2,435,926
14,795	Broadcom, Inc.	9,316,116
19,714	Entegris, Inc.	2,587,660
182,204	Intel Corp.	9,030,030
10,758	KLA Corp.	3,938,073
4,583	Lam Research Corp.	2,463,867
41,078	Lattice Semiconductor Corp. (a)	2,503,704
37,645	Marvell Technology, Inc.	2,699,523
36,575	Microchip Technology, Inc.	2,748,246
79,157	Micron Technology, Inc.	6,165,539
5,608	Monolithic Power Systems, Inc.	2,723,693
10,549	NVIDIA Corp.	2,878,400
13,530	NXP Semiconductors N.V.	2,504,132
69,407	ON Semiconductor Corp. (a)	4,345,572
28,581	Power Integrations, Inc.	2,648,887
18,807	Qorvo, Inc. (a)	2,333,949
37,283	QUALCOMM, Inc.	5,697,588
16,735	Silicon Laboratories, Inc. (a)	2,513,597
12,725	SiTime Corp. (a)	3,153,510
25,427	Skyworks Solutions, Inc.	3,388,911
11,292	Synaptics, Inc. (a)	2,252,754
21,814	Teradyne, Inc.	2,579,069
39,848	Texas Instruments, Inc.	7,311,311
25,042	Wolfspeed, Inc. (a)	2,851,282
		101,549,869
	Total Investments – 99.8%	108,250,992
	(Cost $107,226,769)
	Net Other Assets and Liabilities – 0.2%	199,711
	Net Assets – 100.0%	$108,450,703

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 108,250,992	$ 108,250,992	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 29

Table of Contents

First Trust Nasdaq Transportation ETF (FTXR)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.6%
	Air Freight & Logistics – 16.2%
113,042	CH Robinson Worldwide, Inc.	$12,175,754
105,738	Expeditors International of Washington, Inc.	10,907,932
49,164	FedEx Corp.	11,376,058
51,940	United Parcel Service, Inc., Class B	11,139,052
		45,598,796
	Airlines – 8.0%
68,977	Alaska Air Group, Inc. (a)	4,001,356
209,921	American Airlines Group, Inc. (a)	3,831,058
90,714	Delta Air Lines, Inc. (a)	3,589,553
237,135	JetBlue Airways Corp. (a)	3,545,168
82,673	Southwest Airlines Co. (a)	3,786,424
81,553	United Airlines Holdings, Inc. (a)	3,780,797
		22,534,356
	Auto Components – 8.7%
27,973	Aptiv PLC (a)	3,348,648
233,769	Goodyear Tire & Rubber (The) Co. (a)	3,340,559
65,097	Lear Corp.	9,282,181
258,099	Luminar Technologies, Inc. (a) (b)	4,034,087
224,360	QuantumScape Corp. (a) (b)	4,484,957
		24,490,432
	Automobiles – 12.3%
296,807	Fisker, Inc. (a) (b)	3,828,810
1,089,326	Ford Motor Co.	18,420,503
175,468	General Motors Co. (a)	7,674,970
4,159	Tesla, Inc. (a)	4,481,739
		34,406,022
	Distributors – 3.8%
232,781	LKQ Corp.	10,570,585
	Machinery – 9.2%
458,364	Nikola Corp. (a)	4,909,079
238,087	PACCAR, Inc.	20,968,322
		25,877,401
	Road & Rail – 37.1%
612,741	CSX Corp.	22,947,150
107,715	JB Hunt Transport Services, Inc.	21,628,095
42,602	Norfolk Southern Corp.	12,150,942
34,802	Old Dominion Freight Line, Inc.	10,394,661
38,046	Saia, Inc. (a)	9,276,376
88,870	Union Pacific Corp.	24,280,173
49,825	XPO Logistics, Inc. (a)	3,627,260
		104,304,657

Shares	Description	Value

	Trading Companies & Distributors – 4.3%
33,983	United Rentals, Inc. (a)	$12,071,101
	Total Common Stocks	279,853,350
	(Cost $292,622,727)
MONEY MARKET FUNDS – 3.0%
8,319,356	Goldman Sachs Financial Square Treasury Obligations Fund - Institutional Class - 0.20% (c) (d)	8,319,356
	(Cost $8,319,356)
Principal Value	Description	Value
REPURCHASE AGREEMENTS – 0.3%
$927,929	BNP Paribas S.A., 0.24% (c), dated 3/31/22, due 4/1/22, with a maturity value of $927,935. Collateralized by U.S. Treasury Note, interest rate of 0.25%, due 9/30/25. The value of the collateral including accrued interest is $945,420. (d)	927,929
	(Cost $927,929)
	Total Investments – 102.9%	289,100,635
	(Cost $301,870,012)
	Net Other Assets and Liabilities – (2.9)%	(8,258,909)
	Net Assets – 100.0%	$280,841,726

(a)	Non-income producing security.
(b)	All or a portion of this security is on loan (See Note 2E - Securities Lending in the Notes to Financial Statements). The remaining contractual maturity of all of the securities lending transactions is overnight and continuous. The aggregate value of such securities is $8,968,935 and the total value of the collateral held by the Fund is $9,247,285.
(c)	Rate shown reflects yield as of March 31, 2022.
(d)	This security serves as collateral for securities on loan.

Offsetting Assets and Liabilities

Offsetting assets and liabilities requires entities to disclose both gross and net information about instruments and transactions eligible for offset, and to disclose instruments and transactions subject to master netting or similar agreements (see Note 2D – Offsetting on the Statements of Assets and Liabilities in the Notes to Financial Statements).

The Fund’s loaned securities were all subject to an enforceable Securities Lending Agency Agreement. Securities lent in accordance with the Securities Lending Agency Agreement on a gross basis were as follows:

Page 30

See Notes to Financial Statements

Table of Contents

First Trust Nasdaq Transportation ETF (FTXR)

Portfolio of Investments (Continued)

March 31, 2022

Security Lending Agency Agreement
Total gross amount presented on the Statements of Assets and Liabilities ⁽¹⁾	$8,968,935
Non-cash Collateral ⁽²⁾	(8,968,935)
Net Amount	$—

⁽¹⁾	The amount presented on the Statements of Assets and Liabilities, which is included in “Investments, at value,” is not offset and is shown on a gross basis.
⁽²⁾	At March 31, 2022, the value of the collateral received from each borrower exceeded the value of the related securities loaned. This amount is disclosed on the Portfolio of Investments.

The Fund’s investments in repurchase agreements were all subject to an enforceable Master Repurchase Agreement. Repurchase Agreements on a gross basis were as follows:

Repurchase Agreements
Total gross amount presented on the Statements of Assets and Liabilities ⁽³⁾	$927,929
Non-cash Collateral ⁽⁴⁾	(927,929)
Net Amount	$—

⁽³⁾	The amount is included in “Investments, at value” on the Statements of Assets and Liabilities.
⁽⁴⁾	At March 31, 2022, the value of the collateral received from each seller exceeded the value of the repurchase agreements.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2022 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2022	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 279,853,350	$ 279,853,350	$ —	$ —
Money Market Funds	8,319,356	8,319,356	—	—
Repurchase Agreements	927,929	—	927,929	—
Total Investments	$ 289,100,635	$ 288,172,706	$ 927,929	$—

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 31

Table of Contents

First Trust S-Network Streaming & Gaming ETF (BNGE)

Portfolio of Investments

March 31, 2022

Shares	Description	Value
COMMON STOCKS – 99.5%
	Australia – 4.7%
3,831	Aristocrat Leisure Ltd. (a)	$103,981
4,407	PointsBet Holdings Ltd. (a) (b)	12,289
11,715	Tabcorp Holdings Ltd. (a)	46,674
		162,944
	Cayman Islands – 16.0%
2,196	Bilibili, Inc., ADR (b)	56,174
2,193	Hello Group, Inc., ADR (b)	12,676
4,353	iQIYI, Inc., ADR (b)	19,763
399	JOYY, Inc., ADR	14,655
13,056	Kuaishou Technology (a) (b) (c) (d)	119,628
1,794	NetEase, Inc., ADR	160,904
2,928	Tencent Holdings Ltd. (a)	134,964
8,520	Tencent Music Entertainment Group, ADR (b)	41,492
		560,256
	Greece – 0.5%
1,326	OPAP S.A. (a)	19,302
	Ireland – 2.3%
690	Flutter Entertainment PLC (a) (b)	79,881
	Isle Of Man (U.K.) – 2.2%
2,784	Entain PLC (a) (b)	59,636
2,076	Playtech PLC (b)	16,145
		75,781
	Japan – 9.4%
356	Nintendo Co., Ltd. (a)	179,696
1,438	Sony Group Corp. (a)	147,935
		327,631
	Luxembourg – 2.4%
567	Spotify Technology S.A. (b)	85,628
	Malta – 1.0%
750	Kambi Group PLC (a) (b)	17,210
1,632	Kindred Group PLC, SDR (a)	17,806
		35,016
	South Africa – 0.7%
2,553	MultiChoice Group	23,015
	South Korea – 1.8%
168	Krafton, Inc. (a) (b)	37,848
1,554	NHN BUGS, Corp. (a) (b)	25,651
		63,499
	Sweden – 2.8%
786	Evolution AB (a) (c) (d)	79,963
429	Nordic Entertainment Group AB, Class B (a) (b)	17,323
		97,286

Shares	Description	Value

	United States – 55.7%
2,832	Activision Blizzard, Inc.	$226,872
1,368	Advanced Micro Devices, Inc. (b)	149,577
4,572	DraftKings, Inc., Class A (b)	89,017
1,389	Electronic Arts, Inc.	175,722
1,482	fuboTV, Inc. (b)	9,737
357	GameStop Corp., Class A (b)	59,469
972	iHeartMedia, Inc., Class A (b)	18,400
3,309	Intel Corp.	163,994
2,199	MGM Resorts International	92,226
348	Netflix, Inc. (b)	130,357
681	NVIDIA Corp.	185,818
804	Penn National Gaming, Inc. (b)	34,106
1,884	ROBLOX Corp., Class A (b)	87,116
756	Roku, Inc. (b)	94,704
1,614	Rush Street Interactive, Inc. (b)	11,734
444	Scientific Games Corp. (b)	26,085
4,575	Sirius XM Holdings, Inc.	30,286
618	Take-Two Interactive Software, Inc. (b)	95,011
1,050	Unity Software, Inc. (b)	104,170
1,167	Walt Disney (The) Co. (b)	160,066
		1,944,467
	Total Investments – 99.5%	3,474,706
	(Cost $3,645,431)
	Net Other Assets and Liabilities – 0.5%	17,151
	Net Assets – 100.0%	$3,491,857

(a)	This security is fair valued by the Advisor’s Pricing Committee in accordance with procedures adopted by the Trust’s Board of Trustees and in accordance with provisions of the Investment Company Act of 1940, as amended. At March 31, 2022, securities noted as such are valued at $1,099,787 or 31.5% of net assets. Certain of these securities are fair valued using a factor provided by a third-party pricing service due to the change in value between the foreign markets’ close and the New York Stock Exchange close exceeding a certain threshold. On days when this threshold is not exceeded, these securities are typically valued at the last sale price on the exchange on which they are principally traded.
(b)	Non-income producing security.
(c)	This security may be resold to qualified foreign investors and foreign institutional buyers under Regulation S of the Securities Act of 1933, as amended (the “1933 Act”).
(d)	This security is exempt from registration upon resale under Rule 144A of the 1933 Act and may be resold in transactions exempt from registration, normally to qualified institutional buyers. This security is not restricted on the foreign exchange where it trades freely without any additional registration. As such, it does not require the additional disclosure required of restricted securities.

Page 32

See Notes to Financial Statements

Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Assets and Liabilities

March 31, 2022

	First Trust Nasdaq Bank ETF (FTXO)	First Trust Nasdaq Food & Beverage ETF (FTXG)	First Trust Nasdaq Oil & Gas ETF (FTXN)
ASSETS:
Investments, at value	$ 361,134,330	$ 10,802,296	$ 1,145,518,822
Cash	112,828	5,063	2,453,909
Foreign currency	—	—	—
Receivables:
Fund shares sold	1,630,879	1,347,426	4,018,292
Dividends	873,807	6,987	276,416
Dividend reclaims	—	—	—
Securities lending income	—	—	—
Investment securities sold	—	—	—
Total Assets	363,751,844	12,161,772	1,152,267,439
LIABILITIES:
Payables:
Investment securities purchased	1,627,087	1,346,583	4,011,605
Investment advisory fees	188,168	4,706	624,862
Collateral for securities on loan	—	—	—
Fund shares redeemed	—	—	—
Total Liabilities	1,815,255	1,351,289	4,636,467
NET ASSETS	$361,936,589	$10,810,483	$1,147,630,972
NET ASSETS consist of:
Paid-in capital	$ 451,006,625	$ 11,194,575	$ 1,001,938,385
Par value	114,000	4,000	433,500
Accumulated distributable earnings (loss)	(89,184,036)	(388,092)	145,259,087
NET ASSETS	$361,936,589	$10,810,483	$1,147,630,972
NET ASSET VALUE, per share	$31.75	$27.03	$26.47
Number of shares outstanding (unlimited number of shares authorized, par value $0.01 per share)	11,400,002	400,002	43,350,002
Investments, at cost	$366,326,636	$10,007,726	$980,129,753
Foreign currency, at cost (proceeds)	$—	$—	$—
Securities on loan, at value	$—	$—	$—

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Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Operations

For the Period Ended March 31, 2022

	First Trust Nasdaq Bank ETF (FTXO)	First Trust Nasdaq Food & Beverage ETF (FTXG)	First Trust Nasdaq Oil & Gas ETF (FTXN)
INVESTMENT INCOME:
Dividends	$ 6,969,165	$ 150,554	$ 9,121,177
Interest	44	2	241
Securities lending income (net of fees)	—	—	147
Foreign withholding tax	(57,030)	—	—
Other	—	—	7
Total investment income	6,912,179	150,556	9,121,572
EXPENSES:
Investment advisory fees	1,649,361	40,789	2,219,185
Total expenses	1,649,361	40,789	2,219,185
NET INVESTMENT INCOME (LOSS)	5,262,818	109,767	6,902,387
NET REALIZED AND UNREALIZED GAIN (LOSS):
Net realized gain (loss) on:
Investments	(13,814,589)	(636,223)	(34,155,718)
In-kind redemptions	12,795,122	287,212	205,113,067
Foreign currency transactions	—	—	—
Net realized gain (loss)	(1,019,467)	(349,011)	170,957,349
Net change in unrealized appreciation (depreciation) on:
Investments	(11,467,228)	692,861	162,037,630
Foreign currency translation	—	—	—
Net change in unrealized appreciation (depreciation)	(11,467,228)	692,861	162,037,630
NET REALIZED AND UNREALIZED GAIN (LOSS)	(12,486,695)	343,850	332,994,979
NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS	$(7,223,877)	$ 453,617	$ 339,897,366

(a)	Inception date is January 25, 2022, which is consistent with the commencement of investment operations and is the date the initial creation units were established.

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Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets

	First Trust Nasdaq Bank ETF (FTXO)		First Trust Nasdaq Food & Beverage ETF (FTXG)
	Year Ended 3/31/2022	Year Ended 3/31/2021	Year Ended 3/31/2022	Year Ended 3/31/2021
OPERATIONS:
Net investment income (loss)	$ 5,262,818	$ 2,496,898	$ 109,767	$ 37,996
Net realized gain (loss)	(1,019,467)	18,011,029	(349,011)	219,178
Net change in unrealized appreciation (depreciation)	(11,467,228)	49,898,872	692,861	819,716
Net increase (decrease) in net assets resulting from operations	(7,223,877)	70,406,799	453,617	1,076,890
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(5,155,141)	(2,495,731)	(116,496)	(37,626)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	231,246,175	240,319,581	9,224,482	4,989,914
Cost of shares redeemed	(84,224,058)	(139,595,309)	(3,884,145)	(3,488,460)
Net increase (decrease) in net assets resulting from shareholder transactions	147,022,117	100,724,272	5,340,337	1,501,454
Total increase (decrease) in net assets	134,643,099	168,635,340	5,677,458	2,540,718
NET ASSETS:
Beginning of period	227,293,490	58,658,150	5,133,025	2,592,307
End of period	$361,936,589	$227,293,490	$10,810,483	$5,133,025
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	7,300,002	3,750,002	200,002	150,002
Shares sold	6,750,000	8,200,000	350,000	200,000
Shares redeemed	(2,650,000)	(4,650,000)	(150,000)	(150,000)
Shares outstanding, end of period	11,400,002	7,300,002	400,002	200,002

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Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets (Continued)

	First Trust Nasdaq Semiconductor ETF (FTXL)		First Trust Nasdaq Transportation ETF (FTXR)
	Year Ended 3/31/2022	Year Ended 3/31/2021	Year Ended 3/31/2022	Year Ended 3/31/2021
OPERATIONS:
Net investment income (loss)	$ 361,146	$ 248,285	$ 10,254,406	$ 451,189
Net realized gain (loss)	14,839,706	15,506,395	18,134,255	166,462,888
Net change in unrealized appreciation (depreciation)	(11,810,521)	17,121,367	(109,717,327)	97,342,785
Net increase (decrease) in net assets resulting from operations	3,390,331	32,876,047	(81,328,666)	264,256,862
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(338,211)	(248,060)	(10,039,966)	(1,221,540)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	93,443,236	82,131,018	720,128,082	1,605,131,373
Cost of shares redeemed	(72,200,805)	(61,955,704)	(1,419,772,038)	(797,823,739)
Net increase (decrease) in net assets resulting from shareholder transactions	21,242,431	20,175,314	(699,643,956)	807,307,634
Total increase (decrease) in net assets	24,294,551	52,803,301	(791,012,588)	1,070,342,956
NET ASSETS:
Beginning of period	84,156,152	31,352,851	1,071,854,314	1,511,358
End of period	$108,450,703	$84,156,152	$280,841,726	$1,071,854,314
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	1,300,002	950,002	32,600,002	100,002
Shares sold	1,300,000	1,500,000	22,150,000	58,950,000
Shares redeemed	(1,050,000)	(1,150,000)	(46,050,000)	(26,450,000)
Shares outstanding, end of period	1,550,002	1,300,002	8,700,002	32,600,002

(a)	Inception date is January 25, 2022, which is consistent with the commencement of investment operations and is the date the initial creation units were established.

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights

For a share outstanding throughout each period

First Trust Nasdaq Bank ETF (FTXO)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 31.14	$ 15.64	$ 24.41	$ 29.50	$ 25.94
Income from investment operations:
Net investment income (loss)	0.61	0.59 (a)	0.73	0.84	0.40
Net realized and unrealized gain (loss)	0.61 (b)	15.50	(8.77)	(5.14)	3.56
Total from investment operations	1.22	16.09	(8.04)	(4.30)	3.96
Distributions paid to shareholders from:
Net investment income	(0.61)	(0.59)	(0.73)	(0.79)	(0.40)
Net asset value, end of period	$31.75	$31.14	$15.64	$24.41	$29.50
Total return (c)	3.89%	105.13%	(33.93)%	(14.49)%	15.35%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 361,937	$ 227,293	$ 58,658	$ 168,447	$ 1,314,444
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.91%	2.65%	2.69%	1.83%	1.47%
Portfolio turnover rate (d)	78%	176%	59%	87%	39%

(a)	Based on average shares outstanding.
(b)	The per share amount does not correlate with the aggregate realized and unrealized gain (loss) due to the timing of the Fund share sales and repurchases in relation to market value fluctuation of the underlying investments.
(c)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(d)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Food & Beverage ETF (FTXG)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 25.66	$ 17.28	$ 20.06	$ 19.71	$ 20.63
Income from investment operations:
Net investment income (loss)	0.41	0.32	0.27	0.27	0.35
Net realized and unrealized gain (loss)	1.39	8.38	(2.77)	0.33	(0.95)
Total from investment operations	1.80	8.70	(2.50)	0.60	(0.60)
Distributions paid to shareholders from:
Net investment income	(0.43)	(0.32)	(0.28)	(0.25)	(0.32)
Net asset value, end of period	$27.03	$25.66	$17.28	$20.06	$19.71
Total return (a)	7.13%	50.65%	(12.69)%	3.13%	(2.96)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 10,810	$ 5,133	$ 2,592	$ 2,006	$ 985
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.61%	1.44%	1.58%	1.55%	1.53%
Portfolio turnover rate (b)	77%	131%	59%	108%	76%

(a)

Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.

(b)

Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

See Notes to Financial Statements

Page 43

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Oil & Gas ETF (FTXN)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 15.51	$ 8.10	$ 18.91	$ 19.95	$ 20.63
Income from investment operations:
Net investment income (loss)	0.31	0.22	0.31	0.41	0.36
Net realized and unrealized gain (loss)	10.96	7.39	(10.79)	(1.06)	(0.67)
Total from investment operations	11.27	7.61	(10.48)	(0.65)	(0.31)
Distributions paid to shareholders from:
Net investment income	(0.31)	(0.20)	(0.32)	(0.39)	(0.33)
Return of capital	—	—	(0.01)	—	(0.04)
Total distributions	(0.31)	(0.20)	(0.33)	(0.39)	(0.37)
Net asset value, end of period	$26.47	$15.51	$8.10	$18.91	$19.95
Total return (a)	73.19%	95.16%	(56.26)%	(3.27)%	(1.47)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 1,147,631	$ 36,448	$ 6,885	$ 12,294	$ 3,991
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.87%	2.01%	2.14%	1.69%	1.96%
Portfolio turnover rate (b)	139%	136%	76%	126%	92%

(a)

(b)

Page 44

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 25.51	$ 19.36	$ 21.50	$ 21.14	$ 19.83
Income from investment operations:
Net investment income (loss)	0.27	0.24	0.18	0.13	0.17
Net realized and unrealized gain (loss)	1.10	6.14	(2.13)	0.35	1.65
Total from investment operations	1.37	6.38	(1.95)	0.48	1.82
Distributions paid to shareholders from:
Net investment income	(0.25)	(0.23)	(0.19)	(0.12)	(0.17)
Net realized gain	—	—	—	—	(0.34)
Total distributions	(0.25)	(0.23)	(0.19)	(0.12)	(0.51)
Net asset value, end of period	$26.63	$25.51	$19.36	$21.50	$21.14
Total return (a)	5.39%	33.00%	(9.13)%	2.30%	9.32%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 17,311	$ 19,133	$ 5,810	$ 5,376	$ 2,114
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.97%	1.07%	0.85%	0.69%	0.80%
Portfolio turnover rate (b)	77%	83%	42%	107%	70%

(a)

(b)

See Notes to Financial Statements

Page 45

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust S-Network E-Commerce ETF (ISHP)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 31.48	$ 18.10	$ 22.34	$ 20.86	$ 19.68
Income from investment operations:
Net investment income (loss)	0.26	0.19	0.27	0.21	0.31
Net realized and unrealized gain (loss)	(0.54)	13.39	(4.22)	1.45	1.18
Total from investment operations	(0.28)	13.58	(3.95)	1.66	1.49
Distributions paid to shareholders from:
Net investment income	(0.22)	(0.20)	(0.29)	(0.18)	(0.31)
Net asset value, end of period	$30.98	$31.48	$18.10	$22.34	$20.86
Total return (a)	(0.94)%	75.23%	(17.90)%	7.98%	7.63%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 18,586	$ 9,444	$ 3,619	$ 8,934	$ 1,043
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.91%	0.70%	1.11%	1.41%	1.54%
Portfolio turnover rate (b)	213%	114%	65%	127%	126%

(a)

(b)

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Semiconductor ETF (FTXL)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 64.74	$ 33.00	$ 31.83	$ 32.58	$ 25.04
Income from investment operations:
Net investment income (loss)	0.27	0.23	0.38	0.25	0.14
Net realized and unrealized gain (loss)	5.22	31.75	1.18	(0.79)	7.54
Total from investment operations	5.49	31.98	1.56	(0.54)	7.68
Distributions paid to shareholders from:
Net investment income	(0.26)	(0.24)	(0.39)	(0.21)	(0.14)
Net asset value, end of period	$69.97	$64.74	$33.00	$31.83	$32.58
Total return (a)	8.46%	97.11%	4.82%	(1.62)%	30.77%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 108,451	$ 84,156	$ 31,353	$ 30,242	$ 47,247
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.40%	0.45%	1.00%	0.78%	0.55%
Portfolio turnover rate (b)	58%	113%	64%	94%	59%

(a)

(b)

See Notes to Financial Statements

Page 47

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Transportation ETF (FTXR)

	Year Ended March 31,
	2022	2021	2020	2019	2018
Net asset value, beginning of period	$ 32.88	$ 15.11	$ 23.33	$ 24.93	$ 22.78
Income from investment operations:
Net investment income (loss)	0.45	0.04	0.30	0.35	0.32
Net realized and unrealized gain (loss)	(0.62)	17.79	(8.22)	(1.62)	2.16
Total from investment operations	(0.17)	17.83	(7.92)	(1.27)	2.48
Distributions paid to shareholders from:
Net investment income	(0.43)	(0.06)	(0.30)	(0.33)	(0.33)
Net asset value, end of period	$32.28	$32.88	$15.11	$23.33	$24.93
Total return (a)	(0.53)%	118.10%	(34.35)%	(5.11)%	10.89%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 280,842	$ 1,071,854	$ 1,511	$ 2,333	$ 3,740
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.92%	0.10%	1.04%	1.38%	1.27%
Portfolio turnover rate (b)	43%	129%	89%	108%	78%

(a)

(b)

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Financial Highlights (Continued)

For a share outstanding throughout the period

First Trust S-Network Streaming & Gaming ETF (BNGE)

	Period Ended 3/31/2022 (a)
Net asset value, beginning of period	$ 24.46
Income from investment operations:
Net investment income (loss)	0.02
Net realized and unrealized gain (loss)	(1.20)
Total from investment operations	(1.18)
Distributions paid to shareholders from:
Net investment income	(0.00) (b)
Net asset value, end of period	$23.28
Total return (c)	(4.81)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 3,492
Ratio of total expenses to average net assets	0.70% (d)
Ratio of net investment income (loss) to average net assets	0.47% (d)
Portfolio turnover rate (e)	0%

(a)	Inception date is January 25, 2022, which is consistent with the commencement of investment operations and is the date the initial creation units were established.
(b)	Amount is less than $0.01.
(c)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The return presented does not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(d)	Annualized.
(e)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

See Notes to Financial Statements

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March 31, 2022

1. Organization

First Trust Exchange-Traded Fund VI (the “Trust”) is an open-end management investment company organized as a Massachusetts business trust on June 4, 2012, and is registered with the Securities and Exchange Commission under the Investment Company Act of 1940, as amended (the “1940 Act”).

The Trust currently consists of thirty-three exchange-traded funds that are offering shares. This report covers the eight funds (each a “Fund” and collectively, the “Funds”) listed below, each a non-diversified series of the Trust and listed and traded on The Nasdaq Stock Market LLC (“Nasdaq”) with the exception of BNGE which is listed and traded on The NYSE Arca, Inc.

First Trust Nasdaq Bank ETF - (ticker “FTXO”)

First Trust Nasdaq Food & Beverage ETF - (ticker “FTXG”)

First Trust Nasdaq Oil & Gas ETF - (ticker “FTXN”)

First Trust Nasdaq Pharmaceuticals ETF - (ticker “FTXH”)

First Trust S-Network E-Commerce ETF - (ticker “ISHP”)⁽¹⁾

First Trust Nasdaq Semiconductor ETF - (ticker “FTXL”)

First Trust Nasdaq Transportation ETF - (ticker “FTXR”)

First Trust S-Network Streaming & Gaming ETF - (ticker “BNGE”)⁽²⁾

⁽¹⁾ Effective on January 26, 2022, First Trust Nasdaq Retail ETF (Nasdaq ticker “FTXD”) changed its

name and ticker symbol to First Trust S-Network E-Commerce ETF (Nasdaq ticker “ISHP”).

⁽²⁾ Commenced investment operations on January 25, 2022.

Each Fund represents a separate series of shares of beneficial interest in the Trust. Unlike conventional mutual funds, each Fund issues and redeems shares on a continuous basis, at net asset value (“NAV”), only in large blocks of shares known as “Creation Units.” The investment objective of each Fund is to seek investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of the following indices:

Fund	Index
First Trust Nasdaq Bank ETF	Nasdaq US Smart Banks Index^TM
First Trust Nasdaq Food & Beverage ETF	Nasdaq US Smart Food & Beverage Index^TM
First Trust Nasdaq Oil & Gas ETF	Nasdaq US Smart Oil & Gas Index^TM
First Trust Nasdaq Pharmaceuticals ETF	Nasdaq US Smart Pharmaceuticals Index^TM
First Trust S-Network E-Commerce ETF	S-Network Global E-Commerce Index
First Trust Nasdaq Semiconductor ETF	Nasdaq US Smart Semiconductor Index^TM
First Trust Nasdaq Transportation ETF	Nasdaq US Smart Transportation Index^TM
First Trust S-Network Streaming & Gaming ETF	S-Network Streaming & Gaming Index

2. Significant Accounting Policies

The Funds are each considered an investment company and follow accounting and reporting guidance under Financial Accounting Standards Board Accounting Standards Codification Topic 946, “Financial Services-Investment Companies.” The following is a summary of significant accounting policies consistently followed by the Funds in the preparation of the financial statements. The preparation of the financial statements in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) requires management to make estimates and assumptions that affect the reported amounts and disclosures in the financial statements. Actual results could differ from those estimates.

A. Portfolio Valuation

Each Fund’s NAV is determined daily as of the close of regular trading on the New York Stock Exchange (“NYSE”), normally 4:00 p.m. Eastern time, on each day the NYSE is open for trading. If the NYSE closes early on a valuation day, the NAV is determined as of that time. Foreign securities are priced using data reflecting the earlier closing of the principal markets for those securities. Each Fund’s NAV is calculated by dividing the value of all assets of each Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of shares outstanding.

Each Fund’s investments are valued daily at market value or, in the absence of market value with respect to any portfolio securities, at fair value. Market value prices represent last sale or official closing prices from a national or foreign exchange (i.e., a regulated market) and are primarily obtained from third-party pricing services. Fair value prices represent any prices not considered market value prices and are either obtained from a third-party pricing service or are determined by the Pricing Committee of the Funds’

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investment advisor, First Trust Advisors L.P. (“First Trust” or the “Advisor”), in accordance with valuation procedures adopted by the Trust’s Board of Trustees, and in accordance with provisions of the 1940 Act. Investments valued by the Advisor’s Pricing Committee, if any, are footnoted as such in the footnotes to the Portfolio of Investments. Each Fund’s investments are valued as follows:

Common stocks and other equity securities listed on any national or foreign exchange (excluding Nasdaq and the London Stock Exchange Alternative Investment Market (“AIM”)) are valued at the last sale price on the exchange on which they are principally traded or, for Nasdaq and AIM securities, the official closing price. Securities traded on more than one securities exchange are valued at the last sale price or official closing price, as applicable, at the close of the securities exchange representing the principal market for such securities.

Securities trading on foreign exchanges or over-the-counter markets that close prior to the NYSE close may be valued using a systematic fair valuation model provided by a third-party pricing service. If these foreign securities meet certain criteria in relation to the valuation model, their valuation is systematically adjusted to reflect the impact of movement in the U.S. market after the close of the foreign markets.

Shares of open-end funds are valued at fair value which is based on NAV per share.

Securities traded in an over-the-counter market are fair valued at the mean of their most recent bid and asked price, if available, and otherwise at their closing bid price.

Overnight repurchase agreements are valued at amortized cost when it represents the best estimate of fair value.

Certain securities may not be able to be priced by pre-established pricing methods. Such securities may be valued by the Trust’s Board of Trustees or its delegate, the Advisor’s Pricing Committee, at fair value. These securities generally include, but are not limited to, restricted securities (securities which may not be publicly sold without registration under the Securities Act of 1933, as amended) for which a third-party pricing service is unable to provide a market price; securities whose trading has been formally suspended; a security whose market or fair value price is not available from a pre-established pricing source; a security with respect to which an event has occurred that is likely to materially affect the value of the security after the market has closed but before the calculation of a Fund’s NAV or make it difficult or impossible to obtain a reliable market quotation; and a security whose price, as provided by the third-party pricing service, does not reflect the security’s fair value. As a general principle, the current fair value of a security would appear to be the amount which the owner might reasonably expect to receive for the security upon its current sale. When fair value prices are used, generally they will differ from market quotations or official closing prices on the applicable exchanges. A variety of factors may be considered in determining the fair value of such securities, including, but not limited to, the following:

1)	the type of security;
2)	the size of the holding;
3)	the initial cost of the security;
4)	transactions in comparable securities;
5)	price quotes from dealers and/or third-party pricing services;
6)	relationships among various securities;
7)	information obtained by contacting the issuer, analysts, or the appropriate stock exchange;
8)	an analysis of the issuer’s financial statements; and
9)	the existence of merger proposals or tender offers that might affect the value of the security.

If the securities in question are foreign securities, the following additional information may be considered:

1)	the value of similar foreign securities traded on other foreign markets;
2)	ADR trading of similar securities;
3)	closed-end fund or exchange-traded fund trading of similar securities;
4)	foreign currency exchange activity;
5)	the trading prices of financial products that are tied to baskets of foreign securities;
6)	factors relating to the event that precipitated the pricing problem;
7)	whether the event is likely to recur; and
8)	whether the effects of the event are isolated or whether they affect entire markets, countries or regions.

In addition, differences between the prices used to calculate a Fund’s NAV and the prices used by such Fund’s corresponding index could result in a difference between a Fund’s performance and the performance of its underlying index.

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Because foreign markets may be open on different days than the days during which investors may transact in the shares of a Fund, the value of the Fund’s securities may change on the days when investors are not able to transact in the shares of the Fund. The value of securities denominated in foreign currencies is converted into U.S. dollars using exchange rates determined daily as of the close of regular trading on the NYSE. Any use of a different rate from the rates used by a relevant index may adversely affect the Fund’s ability to track the index.

The Funds are subject to fair value accounting standards that define fair value, establish the framework for measuring fair value and provide a three-level hierarchy for fair valuation based upon the inputs to the valuation as of the measurement date. The three levels of the fair value hierarchy are as follows:

•	Level 1 – Level 1 inputs are quoted prices in active markets for identical investments. An active market is a market in which transactions for the investment occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
•	Level 2 – Level 2 inputs are observable inputs, either directly or indirectly, and include the following:

o	Quoted prices for similar investments in active markets.
o	Quoted prices for identical or similar investments in markets that are non-active. A non-active market is a market where there are few transactions for the investment, the prices are not current, or price quotations vary substantially either over time or among market makers, or in which little information is released publicly.
o	Inputs other than quoted prices that are observable for the investment (for example, interest rates and yield curves observable at commonly quoted intervals, volatilities, prepayment speeds, loss severities, credit risks, and default rates).
o	Inputs that are derived principally from or corroborated by observable market data by correlation or other means.

•	Level 3 – Level 3 inputs are unobservable inputs. Unobservable inputs may reflect the reporting entity’s own assumptions about the assumptions that market participants would use in pricing the investment.

The inputs or methodologies used for valuing investments are not necessarily an indication of the risk associated with investing in those investments. A summary of the inputs used to value each Fund’s investments as of March 31, 2022, is included with each Fund’s Portfolio of Investments.

B. Securities Transactions and Investment Income

Securities transactions are recorded as of the trade date. Realized gains and losses from securities transactions are recorded on the identified cost basis. Dividend income is recorded on the ex-dividend date except that certain dividends from foreign securities are recorded as soon as the information becomes available after the ex-dividend date. Interest income, if any, is recorded on the accrual basis.

Withholding taxes and tax reclaims on foreign dividends have been provided for in accordance with each Fund’s understanding of the applicable country’s tax rules and rates.

C. Foreign Currency

The books and records of the Funds are maintained in U.S. dollars. Foreign currencies, investments and other assets and liabilities are translated into U.S. dollars at the exchange rates prevailing at the end of the period. Purchases and sales of investments and items of income and expense are translated on the respective dates of such transactions. Unrealized gains and losses on assets and liabilities, other than investments in securities, which result from changes in foreign currency exchange rates have been included in “Net change in unrealized appreciation (depreciation) on foreign currency translation” on the Statements of Operations. Unrealized gains and losses on investments in securities which result from changes in foreign exchange rates are included with fluctuations arising from changes in market price and are included in “Net change in unrealized appreciation (depreciation) on investments” on the Statements of Operations. Net realized foreign currency gains and losses include the effect of changes in exchange rates between trade date and settlement date on investment security transactions, foreign currency transactions and interest and dividends received and are included in “Net realized gain (loss) on foreign currency transactions” on the Statements of Operations. The portion of foreign currency gains and losses related to fluctuations in exchange rates between the initial purchase settlement date and subsequent sale trade date is included in “Net realized gain (loss) on investments” on the Statements of Operations.

D. Offsetting on the Statements of Assets and Liabilities

Offsetting assets and liabilities requires entities to disclose both gross and net information about instruments and transactions eligible for offset on the Statements of Assets and Liabilities and disclose instruments and transactions subject to master netting or similar agreements. These disclosure requirements are intended to help investors and other financial statement users better assess the effect or

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March 31, 2022

potential effect of offsetting arrangements on a Fund’s financial position. The transactions subject to offsetting disclosures are derivative instruments, repurchase agreements and reverse repurchase agreements, and securities borrowing and securities lending transactions.

This disclosure, if applicable, is included within each Fund’s Portfolio of Investments under the heading “Offsetting Assets and Liabilities.” For financial reporting purposes, the Funds do not offset financial assets and financial liabilities that are subject to master netting arrangements (“MNAs”) or similar agreements on the Statements of Assets and Liabilities. MNAs provide the right, in the event of default (including bankruptcy and insolvency), for the non-defaulting counterparty to liquidate the collateral and calculate the net exposure to the defaulting party or request additional collateral.

E. Securities Lending

The Funds may lend securities representing up to 33 1/3% of the value of their total assets to broker-dealers, banks and other institutions to generate additional income. When a Fund loans its portfolio securities, it will receive, at the inception of each loan, collateral equal to at least 102% (for domestic securities) or 105% (for international securities) of the market value of the loaned securities. The collateral amount is valued at the beginning of each business day and is compared to the market value of the loaned securities from the prior business day to determine if additional collateral is required. If additional collateral is required, a request is sent to the borrower. Securities lending involves the risk that the Fund may lose money because the borrower of the Fund’s loaned securities fails to return the securities in a timely manner or at all. The Fund could also lose money in the event of (i) a decline in the value of the collateral provided for the loaned securities, (ii) a decline in the value of any investments made with cash collateral or (iii) an increase in the value of the loaned securities if the borrower does not increase the collateral accordingly and the borrower fails to return the securities. These events could also trigger adverse tax consequences for the Funds.

Under the Funds’ Securities Lending Agency Agreement, the securities lending agent will generally bear the risk that a borrower may default on its obligation to return loaned securities. Brown Brothers Harriman & Co. (“BBH”) acts as the Funds’ securities lending agent and is responsible for executing the lending of the portfolio securities to creditworthy borrowers. The Funds, however, will be responsible for the risks associated with the investment of cash collateral. A Fund may lose money on its investment of cash collateral, which may affect its ability to repay the collateral to the borrower without the use of other Fund assets. Each Fund that engages in securities lending receives compensation (net of any rebate and securities lending agent fees) for lending its securities. Compensation can be in the form of fees received from the securities lending agent or dividends or interest earned from the investment of cash collateral. The fees received from the securities lending agent are accrued daily. The dividend and interest earned on the securities loaned is accounted for in the same manner as other dividend and interest income. At March 31, 2022, only FTXR had securities in the securities lending program. During the fiscal period ended March 31, 2022, FTXN and FTXR participated in the securities lending program.

In the event of a default by a borrower with respect to any loan, BBH will exercise any and all remedies provided under the applicable borrower agreement to make the Funds whole. These remedies include purchasing replacement securities by applying the collateral held from the defaulting broker against the purchase cost of the replacement securities. If, despite such efforts by BBH to exercise these remedies, a Fund sustains losses as a result of a borrower’s default, BBH will indemnify the Fund by purchasing replacement securities at its own expense, or paying the Funds an amount equal to the market value of the replacement securities, subject to certain limitations which are set forth in detail in the Securities Lending Agency Agreement between the Trust on behalf of the Funds and BBH.

F. Repurchase Agreements

Repurchase agreements involve the purchase of securities subject to the seller’s agreement to repurchase the securities at a mutually agreed upon date and price, under the terms of a Master Repurchase Agreement (“MRA”). During the term of a repurchase agreement, the value of the underlying securities held as collateral on behalf of a Fund, including accrued interest, is required to exceed the value of the repurchase agreement, including accrued interest. The underlying securities for all repurchase agreements are held at the Funds’ custodian or designated sub-custodians under tri-party repurchase agreements.

MRAs govern transactions between a Fund and select counterparties. The MRAs maintain provisions for, among other things, initiation, income payments, events of default, and maintenance of collateral for repurchase agreements.

Repurchase agreements received for lending securities are collateralized by U.S. Treasury securities. The U.S. Treasury securities are held in a joint custody account at BBH on behalf of the Funds participating in the securities lending program. In the event the counterparty defaults on the repurchase agreement, the U.S. Treasury securities can either be maintained as part of a Fund’s portfolio or sold for cash. A Fund could suffer a loss to the extent that the proceeds from the sale of the underlying collateral held by the Fund are less than the repurchase price and the Fund’s costs associated with the delay and enforcement of the MRA.

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While the Funds may invest in repurchase agreements, any repurchase agreements held by the Funds during the fiscal period ended March 31, 2022, were received as collateral for lending securities.

G. Dividends and Distributions to Shareholders

Dividends from net investment income, if any, are declared and paid quarterly by each Fund, or as the Board of Trustees may determine from time to time. Distributions of net realized capital gains earned by each Fund, if any, are distributed at least annually.

Distributions from net investment income and realized capital gains are determined in accordance with federal income tax regulations, which may differ from U.S. GAAP. Certain capital accounts in the financial statements are periodically adjusted for permanent differences in order to reflect their tax character. These permanent differences are primarily due to the varying treatment of income and gain/loss on portfolio securities held by the Funds and have no impact on net assets or NAV per share. Temporary differences, which arise from recognizing certain items of income, expense and gain/loss in different periods for financial statement and tax purposes, will reverse at some time in the future.

The tax character of distributions paid by each Fund during the fiscal period ended March 31, 2022, was as follows:

	Distributions paid from Ordinary Income	Distributions paid from Capital Gains	Distributions paid from Return of Capital
First Trust Nasdaq Bank ETF	$ 5,155,141	$ —	$ —
First Trust Nasdaq Food & Beverage ETF	116,496	—	—
First Trust Nasdaq Oil & Gas ETF	6,320,716	—	—
First Trust Nasdaq Pharmaceuticals ETF	176,100	—	—
First Trust S-Network E-Commerce ETF	143,821	—	—
First Trust Nasdaq Semiconductor ETF	338,211	—	—
First Trust Nasdaq Transportation ETF	10,039,966	—	—
First Trust S-Network Streaming & Gaming ETF	405	—	—

The tax character of distributions paid by each Fund during the fiscal year ended March 31, 2021, was as follows:

	Distributions paid from Ordinary Income	Distributions paid from Capital Gains	Distributions paid from Return of Capital
First Trust Nasdaq Bank ETF	$ 2,495,731	$ —	$ —
First Trust Nasdaq Food & Beverage ETF	37,626	—	—
First Trust Nasdaq Oil & Gas ETF	342,435	—	—
First Trust Nasdaq Pharmaceuticals ETF	161,361	—	—
First Trust S-Network E-Commerce ETF	41,275	—	—
First Trust Nasdaq Semiconductor ETF	248,060	—	—
First Trust Nasdaq Transportation ETF	1,221,540	—	—

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March 31, 2022

As of March 31, 2022, the components of distributable earnings on a tax basis for each Fund were as follows:

	Undistributed Ordinary Income	Accumulated Capital and Other Gain (Loss)	Net Unrealized Appreciation (Depreciation)
First Trust Nasdaq Bank ETF	$ 329,822	$ (80,781,438)	$ (8,732,420)
First Trust Nasdaq Food & Beverage ETF	—	(1,052,735)	664,643
First Trust Nasdaq Oil & Gas ETF	624,468	(12,848,893)	157,483,512
First Trust Nasdaq Pharmaceuticals ETF	21,285	(2,169,600)	1,486,069
First Trust S-Network E-Commerce ETF	24,184	(3,151,002)	(1,954,358)
First Trust Nasdaq Semiconductor ETF	45,521	(6,130,872)	(65,969)
First Trust Nasdaq Transportation ETF	214,440	(36,427,903)	(13,693,799)
First Trust S-Network Streaming & Gaming ETF	10,975	—	(179,435)

H. Income Taxes

Each Fund intends to qualify or continue to qualify as a regulated investment company by complying with the requirements under Subchapter M of the Internal Revenue Code of 1986, as amended, which includes distributing substantially all of its net investment income and net realized gains to shareholders. Accordingly, no provision has been made for federal and state income taxes. However, due to the timing and amount of distributions, each Fund may be subject to an excise tax of 4% of the amount by which approximately 98% of each Fund’s taxable income exceeds the distributions from such taxable income for the calendar year.

The Funds are subject to accounting standards that establish a minimum threshold for recognizing, and a system for measuring, the benefits of a tax position taken or expected to be taken in a tax return. For all the Funds, with the exception of BNGE, the taxable years ended 2019, 2020, 2021, and 2022 remain open to federal and state audit. Taxable period ended 2022 remains open to federal and state audit for BNGE. As of March 31, 2022, management has evaluated the application of these standards to the Funds and has determined that no provision for income tax is required in the Funds’ financial statements for uncertain tax positions.

The Funds intend to utilize provisions of the federal income tax laws, which allow them to carry a realized capital loss forward indefinitely following the year of the loss and offset such loss against any future realized capital gains. The Funds are subject to certain limitations under U.S. tax rules on the use of capital loss carryforwards and net unrealized built-in losses. These limitations apply when there has been a 50% change in ownership. At March 31, 2022, for federal income tax purposes, each applicable Fund had a capital loss carryforward available that is shown in the table below, to the extent provided by regulations, to offset future capital gains.

	Non-Expiring Capital Loss Carryforward
First Trust Nasdaq Bank ETF	$ 80,781,438
First Trust Nasdaq Food & Beverage ETF	1,052,735
First Trust Nasdaq Oil & Gas ETF	12,848,893
First Trust Nasdaq Pharmaceuticals ETF	2,169,600
First Trust S-Network E-Commerce ETF	3,151,002
First Trust Nasdaq Semiconductor ETF	6,130,872
First Trust Nasdaq Transportation ETF	36,427,903
First Trust S-Network Streaming & Gaming ETF	—

In order to present paid-in capital and accumulated distributable earnings (loss) (which consists of accumulated net investment income (loss), accumulated net realized gain (loss) on investments and net unrealized appreciation (depreciation) on investments) on the Statements of Assets and Liabilities that more closely represent their tax character, certain adjustments have been made to paid-in capital, accumulated net investment income (loss) and accumulated net realized gain (loss) on investments. These adjustments are primarily due to the difference between book and tax treatments of income and gains on various investment securities held by the

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Funds and in-kind transactions. The results of operations and net assets were not affected by these adjustments. For the fiscal period ended March 31, 2022, the adjustments for each Fund were as follows:

	Accumulated Net Investment Income (Loss)	Accumulated Net Realized Gain (Loss) on Investments	Paid-in Capital
First Trust Nasdaq Bank ETF	$ —	$ (11,750,596)	$ 11,750,596
First Trust Nasdaq Food & Beverage ETF	3,762	(232,143)	228,381
First Trust Nasdaq Oil & Gas ETF	—	(184,911,468)	184,911,468
First Trust Nasdaq Pharmaceuticals ETF	—	(793,272)	793,272
First Trust S-Network E-Commerce ETF	(10,519)	(1,954,354)	1,964,873
First Trust Nasdaq Semiconductor ETF	—	(17,511,520)	17,511,520
First Trust Nasdaq Transportation ETF	—	(48,324,056)	48,324,056
First Trust S-Network Streaming & Gaming ETF	91	(91)	—

As of March 31, 2022, the aggregate cost, gross unrealized appreciation, gross unrealized depreciation, and net unrealized appreciation/(depreciation) on investments (including short positions and derivatives, if any) for federal income tax purposes were as follows:

	Tax Cost	Gross Unrealized Appreciation	Gross Unrealized (Depreciation)	Net Unrealized Appreciation (Depreciation)
First Trust Nasdaq Bank ETF	$ 369,866,750	$ 6,980,746	$ (15,713,166)	$ (8,732,420)
First Trust Nasdaq Food & Beverage ETF	10,137,653	901,395	(236,752)	664,643
First Trust Nasdaq Oil & Gas ETF	988,035,310	162,352,163	(4,868,651)	157,483,512
First Trust Nasdaq Pharmaceuticals ETF	15,803,786	2,180,282	(694,213)	1,486,069
First Trust S-Network E-Commerce ETF	20,501,400	711,620	(2,666,007)	(1,954,387)
First Trust Nasdaq Semiconductor ETF	108,316,961	6,023,916	(6,089,885)	(65,969)
First Trust Nasdaq Transportation ETF	302,794,434	5,721,742	(19,415,541)	(13,693,799)
First Trust S-Network Streaming & Gaming ETF	3,654,148	78,845	(258,287)	(179,442)

I. Expenses

Expenses, other than the investment advisory fee and other excluded expenses, are paid by the Advisor (See Note 3).

First Trust has entered into licensing agreements with Nasdaq, Inc. or S-Network Global Indexes, Inc. (each, a “Licensor”), as applicable, for the Funds. The respective license agreement allows for the use by First Trust of each Fund’s respective index and of certain trademarks and trade names of the Licensor. The Funds are sub-licensees to the applicable license agreements.

3. Investment Advisory Fee, Affiliated Transactions and Other Fee Arrangements

First Trust, the investment advisor to the Funds, is a limited partnership with one limited partner, Grace Partners of DuPage L.P., and one general partner, The Charger Corporation. The Charger Corporation is an Illinois corporation controlled by James A. Bowen, Chief Executive Officer of First Trust. First Trust is responsible for the selection and ongoing monitoring of the securities in each Fund’s portfolio, managing the Funds’ business affairs and providing certain administrative services necessary for the management of the Funds.

First Trust is paid an annual unitary management fee of 0.60% of each Fund’s average daily net assets, except for BNGE. BNGE has agreed to pay First Trust an annual unitary management fee equal to 0.70% of its average daily net assets. First Trust is responsible for the expenses of each Fund including the cost of transfer agency, custody, fund administration, licensing fees, legal, audit, and other services, but excluding fee payments under the Investment Management Agreement, interest, taxes, brokerage commissions and other expenses associated with the execution of portfolio transactions, distribution and service fees pursuant to a Rule 12b-1 plan, if any, acquired fund fees and expenses, and extraordinary expenses, which are paid by each respective Fund. First Trust also provides fund reporting services to the Funds for a flat annual fee in the amount of $9,250 per Fund, which is covered under the annual unitary management fee.

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The Trust has multiple service agreements with Brown Brothers Harriman & Co. (“BBH”). Under the service agreements, BBH performs custodial, fund accounting, certain administrative services, and transfer agency services for the Funds. As custodian, BBH is responsible for custody of each Fund’s assets. As fund accountant and administrator, BBH is responsible for maintaining the books and records of each Fund’s securities and cash. As transfer agent, BBH is responsible for maintaining shareholder records for each Fund.

Each Trustee who is not an officer or employee of First Trust, any sub-advisor or any of their affiliates (“Independent Trustees”) is paid a fixed annual retainer that is allocated equally among each fund in the First Trust Fund Complex. Each Independent Trustee is also paid an annual per fund fee that varies based on whether the fund is a closed-end or other actively managed fund, a defined-outcome fund or an index fund.

Additionally, the Lead Independent Trustee and the Chairs of the Audit Committee, Nominating and Governance Committee and Valuation Committee are paid annual fees to serve in such capacities, with such compensation allocated pro rata among each fund in the First Trust Fund Complex based on net assets. Independent Trustees are reimbursed for travel and out-of-pocket expenses in connection with all meetings. The Lead Independent Trustee and Committee Chairs rotate every three years. The officers and “Interested” Trustee receive no compensation from the Trust for acting in such capacities.

4. Purchases and Sales of Securities

For the fiscal period ended March 31, 2022, the cost of purchases and proceeds from sales of investment securities for each Fund, excluding short-term investments and in-kind transactions, were as follows:

	Purchases	Sales
First Trust Nasdaq Bank ETF	$ 212,636,531	$ 212,113,783
First Trust Nasdaq Food & Beverage ETF	5,306,926	5,298,620
First Trust Nasdaq Oil & Gas ETF	529,870,022	526,508,556
First Trust Nasdaq Pharmaceuticals ETF	14,761,305	14,752,459
First Trust S-Network E-Commerce ETF	39,012,337	38,966,304
First Trust Nasdaq Semiconductor ETF	52,519,320	52,508,869
First Trust Nasdaq Transportation ETF	464,221,385	466,546,514
First Trust S-Network Streaming & Gaming ETF	170,818	—

For the fiscal period ended March 31, 2022, the cost of in-kind purchases and proceeds from in-kind sales for each Fund were as follows:

	Purchases	Sales
First Trust Nasdaq Bank ETF	$ 230,570,235	$ 84,002,642
First Trust Nasdaq Food & Beverage ETF	9,202,719	3,873,418
First Trust Nasdaq Oil & Gas ETF	1,650,425,456	874,932,692
First Trust Nasdaq Pharmaceuticals ETF	2,578,347	5,237,651
First Trust S-Network E-Commerce ETF	36,423,106	24,981,052
First Trust Nasdaq Semiconductor ETF	93,298,085	72,188,868
First Trust Nasdaq Transportation ETF	718,109,261	1,415,834,258
First Trust S-Network Streaming & Gaming ETF	3,474,613	—

5. Creations, Redemptions and Transaction Fees

Each Fund generally issues and redeems its shares in primary market transactions through a creation and redemption mechanism and does not sell or redeem individual shares. Instead, financial entities known as “Authorized Participants” have contractual arrangements with a Fund or one of the Fund’s service providers to purchase and redeem Fund shares directly with the Fund in large blocks of shares known as “Creation Units.” Prior to the start of trading on every business day, a Fund publishes through the National Securities Clearing Corporation (“NSCC”) the “basket” of securities, cash or other assets that it will accept in exchange for a Creation Unit of the Fund’s shares. An Authorized Participant that wishes to effectuate a creation of a Fund’s shares deposits with the Fund the “basket” of securities, cash or other assets identified by the Fund that day, and then receives the Creation Unit of the Fund’s shares in return for those assets. After purchasing a Creation Unit, the Authorized Participant may continue to hold the Fund’s shares or sell them in the

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secondary market. The redemption process is the reverse of the purchase process: the Authorized Participant redeems a Creation Unit of a Fund’s shares for a basket of securities, cash or other assets. The combination of the creation and redemption process with secondary market trading in a Fund’s shares and underlying securities provides arbitrage opportunities that are designed to help keep the market price of a Fund’s shares at or close to the NAV per share of the Fund.

Each Fund imposes fees in connection with the purchase of Creation Units. These fees may vary based upon various fact-based circumstances, including, but not limited to, the composition of the securities included in the Creation Unit or the countries in which the transactions are settled. The price for each Creation Unit will equal the daily NAV per share of a Fund times the number of shares in a Creation Unit, plus the fees described above and, if applicable, any operational processing and brokerage costs, transfer fees, stamp taxes and part or all of the spread between the expected bid and offer side of the market related to the securities comprising the creation basket.

Each Fund also imposes fees in connection with the redemption of Creation Units. These fees may vary based upon various fact-based circumstances, including, but not limited to, the composition of the securities included in the Creation Unit or the countries in which the transactions are settled. The price received for each Creation Unit will equal the daily NAV per share of a Fund times the number of shares in a Creation Unit, minus the fees described above and, if applicable, any operational processing and brokerage costs, transfer fees, stamp taxes and part or all of the spread between the expected bid and offer side of the market related to the securities comprising the redemption basket. Investors who use the services of a broker or other such intermediary in addition to an Authorized Participant to effect a redemption of a Creation Unit may also be assessed an amount to cover the cost of such services. The redemption fee charged by a Fund will comply with Rule 22c-2 of the 1940 Act which limits redemption fees to no more than 2% of the value of the shares redeemed.

6. Distribution Plan

The Board of Trustees adopted a Distribution and Service Plan pursuant to Rule 12b-1 under the 1940 Act. In accordance with the Rule 12b-1 plan, each Fund is authorized to pay an amount up to 0.25% of its average daily net assets each year to reimburse First Trust Portfolios L.P. (“FTP”), the distributor of the Funds, for amounts expended to finance activities primarily intended to result in the sale of Creation Units or to provide investor services. FTP may also use this amount to compensate securities dealers or other persons that are Authorized Participants for providing distribution assistance, including broker-dealer and shareholder support and educational and promotional services.

No 12b-1 fees are currently paid by the Funds, and pursuant to a contractual arrangement, no 12b-1 fees will be paid any time before July 31, 2022 for FTXO, FTXG, FTXN, FTXH, FTXL, and FTXR, January 31, 2023 for ISHP and May 24, 2023 for BNGE.

7. Indemnification

The Trust, on behalf of the Funds, has a variety of indemnification obligations under contracts with its service providers. The Trust’s maximum exposure under these arrangements is unknown. However, the Trust has not had prior claims or losses pursuant to these contracts and expects the risk of loss to be remote.

8. Subsequent Events

Management has evaluated the impact of all subsequent events to the Funds through the date the financial statements were issued and has determined that there were no subsequent events requiring recognition or disclosure in the financial statements that have not already been disclosed.

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Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Trustees of First Trust Exchange-Traded Fund VI:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statements of assets and liabilities of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust S-Network E-Commerce ETF (formerly known as First Trust Nasdaq Retail ETF), First Trust Nasdaq Semiconductor ETF, First Trust Nasdaq Transportation ETF, and First Trust S-Network Streaming & Gaming ETF (the “Funds”), each a series of First Trust Exchange-Traded Fund VI, including the portfolios of investments, as of March 31, 2022, the related statements of operations, the statements of changes in net assets, and the financial highlights for the periods indicated in the table below for the Funds, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of each of the Funds as of March 31, 2022, and the results of their operations, the changes in their net assets, and the financial highlights for the periods indicated in the table below, in conformity with accounting principles generally accepted in the United States of America.

Individual Funds Included in the Trust	Statements of Operations	Statements of Changes in Net Assets	Financial Highlights
First Trust Nasdaq Bank ETF	For the year ended March 31, 2022	For the years ended March 31, 2022 and 2021	For the years ended March 31, 2022, 2021, 2020, 2019, and 2018.
First Trust Nasdaq Food & Beverage ETF
First Trust Nasdaq Oil & Gas ETF
First Trust Nasdaq Pharmaceuticals ETF
First Trust S-Network E-Commerce ETF (Formerly known as First Trust Nasdaq Retail ETF)
First Trust Nasdaq Semiconductor ETF
First Trust Nasdaq Transportation ETF
First Trust S-Network Streaming & Gaming ETF	For the period from January 25, 2022 (commencement of operations) through March 31, 2022

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Funds’ management. Our responsibility is to express an opinion on the Funds’ financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Funds in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Funds are not required to have, nor were we engaged to perform, an audit of their internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Funds’ internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of

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Additional Information

First Trust Exchange-Traded Fund VI

March 31, 2022 (Unaudited)

Proxy Voting Policies and Procedures

A description of the policies and procedures that the Trust uses to determine how to vote proxies and information on how each Fund voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available (1) without charge, upon request, by calling (800) 988-5891; (2) on each Fund’s website at www.ftportfolios.com; and (3) on the Securities and Exchange Commission’s (“SEC”) website at www.sec.gov.

Portfolio Holdings

Each Fund files portfolio holdings information for each month in a fiscal quarter within 60 days after the end of the relevant fiscal quarter on Form N-PORT. Portfolio holdings information for the third month of each fiscal quarter will be publicly available on the SEC’s website at www.sec.gov. Each Fund’s complete schedule of portfolio holdings for the second and fourth quarters of each fiscal year is included in the semi-annual and annual reports to shareholders, respectively, and is filed with the SEC on Form N-CSR. The semi-annual and annual report for each Fund is available to investors within 60 days after the period to which it relates. Each Fund’s Forms N-PORT and Forms N-CSR are available on the SEC’s website listed above.

Federal Tax Information

For the taxable period ended March 31, 2022, the following percentages of income dividend paid by the Funds qualify for the dividends received deduction available to corporations:

	Dividends Received Deduction
First Trust Nasdaq Bank ETF	100.00%
First Trust Nasdaq Food & Beverage ETF	94.37%
First Trust Nasdaq Oil & Gas ETF	100.00%
First Trust Nasdaq Pharmaceuticals ETF	100.00%
First Trust S-Network E-Commerce ETF	100.00%
First Trust Nasdaq Semiconductor ETF	100.00%
First Trust Nasdaq Transportation ETF	100.00%
First Trust S-Network Streaming & Gaming ETF	16.05%

For the taxable period ended March 31, 2022, the following percentages of income dividend paid by the Funds are hereby designated as qualified dividend income:

	Qualified Dividend Income
First Trust Nasdaq Bank ETF	100.00%
First Trust Nasdaq Food & Beverage ETF	94.37%
First Trust Nasdaq Oil & Gas ETF	100.00%
First Trust Nasdaq Pharmaceuticals ETF	100.00%
First Trust S-Network E-Commerce ETF	100.00%
First Trust Nasdaq Semiconductor ETF	100.00%
First Trust Nasdaq Transportation ETF	100.00%
First Trust S-Network Streaming & Gaming ETF	45.68%

A portion of the ordinary dividends (including short-term capital gains) that ISHP paid to shareholders during the taxable period ended March 31, 2022, may be eligible for the Qualified Business Income (QBI) Deduction under the Internal Revenue Code of 1986, as amended, section 199A for the aggregate dividends the Fund received from the underlying Real Estate Investment Trusts (REITs) it invests in.

Risk Considerations

Risks are inherent in all investing. Certain general risks that may be applicable to a Fund are identified below, but not all of the material risks relevant to each Fund are included in this report and not all of the risks below apply to each Fund. The material risks of investing in each Fund are spelled out in its prospectus, statement of additional information and other regulatory filings. Before investing, you should consider each Fund’s investment objective, risks, charges and expenses, and read each

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Fund’s prospectus and statement of additional information carefully. You can download each Fund’s prospectus at www.ftportfolios.com or contact First Trust Portfolios L.P. at (800) 621-1675 to request a prospectus, which contains this and other information about each Fund.

Concentration Risk. To the extent that a fund is able to invest a significant percentage of its assets in a single asset class or the securities of issuers within the same country, state, region, industry or sector, an adverse economic, business or political development may affect the value of the fund’s investments more than if the fund were more broadly diversified. A fund that tracks an index will be concentrated to the extent the fund’s corresponding index is concentrated. A concentration makes a fund more susceptible to any single occurrence and may subject the fund to greater market risk than a fund that is more broadly diversified.

Credit Risk. Credit risk is the risk that an issuer of a security will be unable or unwilling to make dividend, interest and/or principal payments when due and the related risk that the value of a security may decline because of concerns about the issuer’s ability to make such payments.

Cyber Security Risk. The funds are susceptible to potential operational risks through breaches in cyber security. A breach in cyber security refers to both intentional and unintentional events that may cause a fund to lose proprietary information, suffer data corruption or lose operational capacity. Such events could cause a fund to incur regulatory penalties, reputational damage, additional compliance costs associated with corrective measures and/or financial loss. In addition, cyber security breaches of a fund’s third-party service providers, such as its administrator, transfer agent, custodian, or sub-advisor, as applicable, or issuers in which the fund invests, can also subject a fund to many of the same risks associated with direct cyber security breaches.

Defined Outcome Funds Risk. To the extent a fund’s investment strategy is designed to deliver returns tied to the price performance of an underlying ETF, an investor may not realize the returns the fund seeks to achieve if that investor does not hold shares for the entire target outcome period. In the event an investor purchases shares after the first day of the target outcome period or sells shares prior to the end of the target outcome period, the buffer that the fund seeks to provide against a decline in the value of the underlying ETF may not be available, the enhanced returns that the fund seeks to provide (if any) may not be available and the investor may not participate in a gain in the value of the underlying ETF up to the cap for the investor’s investment period. Additionally, the fund will not participate in gains of the underlying ETF above the cap and a shareholder may lose their entire investment. If the fund seeks enhanced returns, there are certain time periods when the value of the fund may fall faster than the value of the underlying ETF, and it is very unlikely that, on any given day during which the underlying ETF share price increases in value, the fund’s share price will increase at the same rate as the enhanced returns sought by the fund, which is designed for an entire target outcome period. Trading flexible exchange options involves risks different from, or possibly greater than, the risks associated with investing directly in securities, such as less liquidity and correlation and valuation risks. A fund may experience substantial downside from specific flexible exchange option positions and certain positions may expire worthless.

Derivatives Risk. To the extent a fund uses derivative instruments such as futures contracts, options contracts and swaps, the fund may experience losses because of adverse movements in the price or value of the underlying asset, index or rate, which may be magnified by certain features of the derivative. These risks are heightened when a fund’s portfolio managers use derivatives to enhance the fund’s return or as a substitute for a position or security, rather than solely to hedge (or offset) the risk of a position or security held by the fund.

Equity Securities Risk. To the extent a fund invests in equity securities, the value of the fund’s shares will fluctuate with changes in the value of the equity securities. Equity securities prices fluctuate for several reasons, including changes in investors’ perceptions of the financial condition of an issuer or the general condition of the relevant stock market, such as market volatility, or when political or economic events affecting the issuers occur. In addition, common stock prices may be particularly sensitive to rising interest rates, as the cost of capital rises and borrowing costs increase. Equity securities may decline significantly in price over short or extended periods of time, and such declines may occur in the equity market as a whole, or they may occur in only a particular country, company, industry or sector of the market.

ETF Risk. The shares of an ETF trade like common stock and represent an interest in a portfolio of securities. The risks of owning an ETF generally reflect the risks of owning the underlying securities, although lack of liquidity in an ETF could result in it being more volatile and ETFs have management fees that increase their costs. Shares of an ETF trade on an exchange at market prices rather than net asset value, which may cause the shares to trade at a price greater than net asset value (premium) or less than net asset value (discount). In times of market stress, decisions by market makers to reduce or step away from their role of providing a market for an ETF’s shares, or decisions by an ETF’s authorized participants that they are unable or unwilling to proceed with creation and/or redemption orders of an ETF’s shares, could result in shares of the ETF trading at a discount to net asset value and in greater than normal intraday bid-ask spreads.

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Fixed Income Securities Risk. To the extent a fund invests in fixed income securities, the fund will be subject to credit risk, income risk, interest rate risk, liquidity risk and prepayment risk. Income risk is the risk that income from a fund’s fixed income investments could decline during periods of falling interest rates. Interest rate risk is the risk that the value of a fund’s fixed income securities will decline because of rising interest rates. Liquidity risk is the risk that a security cannot be purchased or sold at the time desired, or cannot be purchased or sold without adversely affecting the price. Prepayment risk is the risk that the securities will be redeemed or prepaid by the issuer, resulting in lower interest payments received by the fund. In addition to these risks, high yield securities, or “junk” bonds, are subject to greater market fluctuations and risk of loss than securities with higher ratings, and the market for high yield securities is generally smaller and less liquid than that for investment grade securities.

Index or Model Constituent Risk. Certain funds may be a constituent of one or more indices or ETF models. As a result, such a fund may be included in one or more index-tracking exchange-traded funds or mutual funds. Being a component security of such a vehicle could greatly affect the trading activity involving a fund, the size of the fund and the market volatility of the fund. Inclusion in an index could increase demand for the fund and removal from an index could result in outsized selling activity in a relatively short period of time. As a result, a fund’s net asset value could be negatively impacted and the fund’s market price may be significantly below its net asset value during certain periods. In addition, index rebalances may potentially result in increased trading activity in a fund’s shares.

Index Provider Risk. To the extent a fund seeks to track an index, it is subject to Index Provider Risk. There is no assurance that the Index Provider will compile the Index accurately, or that the Index will be determined, maintained, constructed, reconstituted, rebalanced, composed, calculated or disseminated accurately. To correct any such error, the Index Provider may carry out an unscheduled rebalance or other modification of the Index constituents or weightings, which may increase the fund’s costs. The Index Provider does not provide any representation or warranty in relation to the quality, accuracy or completeness of data in the Index, and it does not guarantee that the Index will be calculated in accordance with its stated methodology. Losses or costs associated with any Index Provider errors generally will be borne by the fund and its shareholders.

Investment Companies Risk. To the extent a fund invests in the securities of other investment vehicles, the fund will incur additional fees and expenses that would not be present in a direct investment in those investment vehicles. Furthermore, the fund’s investment performance and risks are directly related to the investment performance and risks of the investment vehicles in which the fund invests.

LIBOR Risk. To the extent a fund invests in floating or variable rate obligations that use the London Interbank Offered Rate (“LIBOR”) as a reference interest rate, it is subject to LIBOR Risk. The United Kingdom’s Financial Conduct Authority, which regulates LIBOR has ceased making LIBOR available as a reference rate over a phase-out period that began December 31, 2021. There is no assurance that any alternative reference rate, including the Secured Overnight Financing Rate (“SOFR”) will be similar to or produce the same value or economic equivalence as LIBOR or that instruments using an alternative rate will have the same volume or liquidity. The unavailability or replacement of LIBOR may affect the value, liquidity or return on certain fund investments and may result in costs incurred in connection with closing out positions and entering into new trades. Any potential effects of the transition away from LIBOR on the fund or on certain instruments in which the fund invests can be difficult to ascertain, and they may vary depending on a variety of factors, and they could result in losses to the fund.

Management Risk. To the extent that a fund is actively managed, it is subject to management risk. In managing an actively-managed fund’s investment portfolio, the fund’s portfolio managers will apply investment techniques and risk analyses that may not have the desired result. There can be no guarantee that a fund will meet its investment objective.

Market Risk. Securities held by a fund, as well as shares of a fund itself, are subject to market fluctuations caused by factors such as general economic conditions, political events, regulatory or market developments, changes in interest rates and perceived trends in securities prices. Shares of a fund could decline in value or underperform other investments as a result of the risk of loss associated with these market fluctuations. In addition, local, regional or global events such as war, acts of terrorism, spread of infectious diseases or other public health issues, recessions, or other events could have a significant negative impact on a fund and its investments. Such events may affect certain geographic regions, countries, sectors and industries more significantly than others. In February 2022, Russia invaded Ukraine which has caused and could continue to cause significant market disruptions and volatility within the markets in Russia, Europe, and the United States. The hostilities and sanctions resulting from those hostilities could have a significant impact on certain fund investments as well as fund performance. The outbreak of the respiratory disease designated as COVID-19 in December 2019 has caused significant volatility and declines in global financial markets, which have caused losses for investors. While the development of vaccines has slowed the spread of the virus and allowed for the resumption of “reasonably” normal business activity in the United States, many countries continue to impose lockdown measures in an attempt to slow the spread. Additionally, there is no guarantee that vaccines will be effective against emerging variants of the disease.

Non-U.S. Securities Risk. To the extent a fund invests in non-U.S. securities, it is subject to additional risks not associated with securities of domestic issuers. Non-U.S. securities are subject to higher volatility than securities of domestic issuers due to: possible adverse political, social or economic developments; restrictions on foreign investment or exchange of securities; capital controls; lack

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of liquidity; currency exchange rates; excessive taxation; government seizure of assets; the imposition of sanctions by foreign governments; different legal or accounting standards; and less government supervision and regulation of exchanges in foreign countries. Investments in non-U.S. securities may involve higher costs than investments in U.S. securities, including higher transaction and custody costs, as well as additional taxes imposed by non-U.S. governments. These risks may be heightened for securities of companies located, or with significant operations, in emerging market countries.

Operational Risk. Each fund is subject to risks arising from various operational factors, including, but not limited to, human error, processing and communication errors, errors of a fund’s service providers, counterparties or other third-parties, failed or inadequate processes and technology or systems failures. Each fund relies on third-parties for a range of services, including custody. Any delay or failure relating to engaging or maintaining such service providers may affect a fund’s ability to meet its investment objective. Although the funds and the funds’ investment advisor seek to reduce these operational risks through controls and procedures, there is no way to completely protect against such risks.

Passive Investment Risk. To the extent a fund seeks to track an index, the fund will invest in the securities included in, or representative of, the index regardless of their investment merit. A fund generally will not attempt to take defensive positions in declining markets.

NOT FDIC INSURED

NOT BANK GUARANTEED

MAY LOSE VALUE

Advisory Agreement

Board Considerations Regarding Approval of Investment Management Agreement

The Board of Trustees of First Trust Exchange-Traded Fund VI (the “Trust”), including the Independent Trustees, approved the Investment Management Agreement (the “Agreement”) with First Trust Advisors L.P. (the “Advisor”), on behalf of the following series of the Trust (the “Fund”):

First Trust S-Network Streaming & Gaming ETF

The Board approved the Agreement for the Fund for an initial two-year term at a meeting held on April 26, 2021. The Board determined for the Fund that the Agreement is in the best interests of the Fund in light of the nature, extent and quality of the services expected to be provided and such other matters as the Board considered to be relevant in the exercise of its business judgment.

To reach this determination for the Fund, the Board considered its duties under the Investment Company Act of 1940, as amended (the “1940 Act”), as well as under the general principles of state law, in reviewing and approving advisory contracts; the requirements of the 1940 Act in such matters; the fiduciary duty of investment advisors with respect to advisory agreements and compensation; the standards used by courts in determining whether investment company boards have fulfilled their duties; and the factors to be considered by the Board in voting on such agreements. To assist the Board in its evaluation of the Agreement for the Fund, the Independent Trustees received a report from the Advisor in advance of the Board meeting responding to a request for information from counsel to the Independent Trustees, submitted on behalf of the Independent Trustees, that, among other things, outlined: the services to be provided by the Advisor to the Fund (including the relevant personnel responsible for these services and their experience); the proposed unitary fee rate payable by the Fund as compared to fees charged to a peer group of funds (the “Expense Group”) and a broad peer universe of funds (the “Expense Universe”), each assembled by Broadridge Financial Solutions, Inc. (“Broadridge”), an independent source, and as compared to fees charged to other exchange-traded funds (“ETFs”) managed by the Advisor; the estimated expense ratio of the Fund as compared to expense ratios of the funds in the Fund’s Expense Group and Expense Universe; the nature of expenses to be incurred in providing services to the Fund and the potential for the Advisor to realize economies of scale, if any; profitability and other financial data for the Advisor; any fall-out benefits to the Advisor and its affiliate, First Trust Portfolios L.P. (“FTP”); and information on the Advisor’s compliance program. The Independent Trustees and their counsel also met separately to discuss the information provided by the Advisor. The Board applied its business judgment to determine whether the arrangement between the Trust and the Advisor is a reasonable business arrangement from the Fund’s perspective.

In evaluating whether to approve the Agreement for the Fund, the Board considered the nature, extent and quality of the services to be provided by the Advisor under the Agreement and considered that employees of the Advisor provide management services to other ETFs and to other funds in the First Trust Fund Complex with diligence and care. The Board considered that the Advisor will be responsible for the overall management and administration of the Fund and reviewed all of the services to be provided by the Advisor to the Fund. The Board also considered the background and experience of the persons who will be responsible for the day-to-day management of the Fund’s investments. In reviewing the services to be provided, the Board noted the compliance program that had been developed by the Advisor and considered that it includes a robust program for monitoring the Advisor’s and the Fund’s compliance with the 1940 Act, as well as the Fund’s compliance with its investment objective, policies and restrictions. Because the Fund had yet to commence investment operations, the Board could not consider the historical investment performance of the Fund.

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Because the Fund is an index ETF that is designed to track the performance of an underlying index, the Board considered reports it receives on a quarterly basis showing the correlation and tracking error between other ETFs for which the Advisor serves as investment advisor and their applicable underlying indexes. In light of the information presented and the considerations made, the Board concluded that the nature, extent and quality of the services to be provided to the Fund by the Advisor under the Agreement are expected to be satisfactory.

The Board considered the proposed unitary fee rate payable by the Fund under the Agreement for the services to be provided. The Board noted that, under the unitary fee arrangement, the Fund would pay the Advisor a unitary fee equal to an annual rate of 0.70% of its average daily net assets. The Board noted that the Advisor would be responsible for the Fund’s expenses, including the cost of transfer agency, custody, fund administration, legal, audit and other services and license fees, if any, but excluding the fee payment under the Agreement and interest, taxes, acquired fund fees and expenses, if any, brokerage commissions and other expenses connected with the execution of portfolio transactions, distribution and service fees pursuant to a Rule 12b-1 plan, if any, and extraordinary expenses, if any. The Board received and reviewed information showing the advisory or unitary fee rates and expense ratios of the peer funds in the Expense Groups, as well as advisory and unitary fee rates charged by the Advisor to other ETFs. Because the Fund will pay a unitary fee, the Board determined that expense ratios were the most relevant comparative data point. Based on the information provided, the Board noted that the unitary fee rate for the Fund was above the median total (net) expense ratio of the peer funds in its Expense Group. With respect to the Expense Group, the Board discussed with representatives of the Advisor how the Expense Group was assembled and how the Fund compared and differed from the peer funds. The Board took this information into account in considering the peer data. With respect to fees charged to other clients, the Board considered differences between the Fund and other clients that limited their comparability. The Board considered the Advisor’s statement that the Fund will be most comparable to three other index ETFs managed by the Advisor that pay unitary fees equal to annual rates of 0.65% or 0.70% of their respective average daily net assets, due to its focus on targeted global exposure with a robust selection methodology and objective to track a given market segment. In light of the information considered and the nature, extent and quality of the services expected to be provided to the Fund under the Agreement, the Board determined that the proposed unitary fee for the Fund was fair and reasonable.

The Board noted that the proposed unitary fee for the Fund was not structured to pass on to shareholders the benefits of any economies of scale as the Fund’s assets grow. The Board noted that any reduction in fixed costs associated with the management of the Fund would benefit the Advisor, but that the unitary fee structure provides a level of certainty in expenses for the Fund. The Board noted that the Advisor has continued to hire personnel and build infrastructure, including technology, to improve the services to the funds in the First Trust Fund Complex. The Board took into consideration the types of costs to be borne by the Advisor in connection with its services to be performed for the Fund under the Agreement. The Board considered the Advisor’s estimate of the asset level for the Fund at which the Advisor expects the Agreement for the Fund to be profitable to the Advisor and the Advisor’s estimate of the profitability of the Agreement for the Fund if its assets reach $100 million. The Board noted the inherent limitations in the profitability analysis and concluded that, based on the information provided, the Advisor’s estimated profitability level for the Fund was not unreasonable. The Board considered fall-out benefits described by the Advisor that may be realized from its relationship with the Fund. The Board considered that the Advisor had identified as a fall-out benefit to the Advisor and FTP their exposure to investors and brokers who, absent their exposure to the Fund, may have had no dealings with the Advisor or FTP. The Board also considered the Advisor’s compensation for fund reporting services to be provided to the Fund pursuant to a separate Fund Reporting Services Agreement, which would be paid from the unitary fee. The Board also noted that the Advisor would not utilize soft dollars in connection with the Fund. The Board concluded that the character and amount of potential fall-out benefits to the Advisor were not unreasonable.

Based on all of the information considered and the conclusions reached, the Board, including the Independent Trustees, determined that the terms of the Agreement are fair and reasonable and that the approval of the Agreement is in the best interests of the Fund. No single factor was determinative in the Board’s analysis.

Page 65

Table of Contents

Board of Trustees and Officers

First Trust Exchange-Traded Fund VI

March 31, 2022 (Unaudited)

The following tables identify the Trustees and Officers of the Trust. Unless otherwise indicated, the address of all persons is 120 East Liberty Drive, Suite 400, Wheaton, IL 60187.

The Trust’s statement of additional information includes additional information about the Trustees and is available, without charge, upon request, by calling (800) 988-5891.

Name, Year of Birth and Position with the Trust	Term of Office and Year First Elected or Appointed	Principal Occupations During Past 5 Years	Number of Portfolios in the First Trust Fund Complex Overseen by Trustee	Other Trusteeships or Directorships Held by Trustee During Past 5 Years
INDEPENDENT TRUSTEES
Richard E. Erickson, Trustee (1951)	• Indefinite Term • Since Inception	Physician, Edward-Elmhurst Medical Group; Physician and Officer, Wheaton Orthopedics (1990 to 2021)	217	None
Thomas R. Kadlec, Trustee (1957)	• Indefinite Term • Since Inception	President, ADM Investor Services, Inc. (Futures Commission Merchant)	217	Director of ADM Investor Services, Inc., ADM Investor Services International, Futures Industry Association, and National Futures Association
Denise M. Keefe, Trustee (1964)	• Indefinite Term • Since 2021	Executive Vice President, Advocate Aurora Health and President, Advocate Aurora Continuing Health Division (Integrated Healthcare System)	217	Director and Board Chair of Advocate Home Health Services, Advocate Home Care Products and Advocate Hospice; Director and Board Chair of Aurora At Home (since 2018); Director of Advocate Physician Partners Accountable Care Organization; Director and Board Chair of RML Long Term Acute Care Hospitals; and Director of Senior Helpers (since 2021)
Robert F. Keith, Trustee (1956)	• Indefinite Term • Since Inception	President, Hibs Enterprises (Financial and Management Consulting)	217	Director of Trust Company of Illinois
Niel B. Nielson, Trustee (1954)	• Indefinite Term • Since Inception	Senior Advisor (August 2018 to Present), Managing Director and Chief Operating Officer (January 2015 to August 2018), Pelita Harapan Educational Foundation (Educational Products and Services)	217	None

Page 66

Table of Contents

Board of Trustees and Officers (Continued)

First Trust Exchange-Traded Fund VI

March 31, 2022 (Unaudited)

Name, Year of Birth and Position with the Trust	Term of Office and Year First Elected or Appointed	Principal Occupations During Past 5 Years	Number of Portfolios in the First Trust Fund Complex Overseen by Trustee	Other Trusteeships or Directorships Held by Trustee During Past 5 Years
INTERESTED TRUSTEE
James A. Bowen⁽¹⁾, Trustee and Chairman of the Board (1955)	• Indefinite Term • Since Inception	Chief Executive Officer, First Trust Advisors L.P. and First Trust Portfolios L.P.; Chairman of the Board of Directors, BondWave LLC (Software Development Company) and Stonebridge Advisors LLC (Investment Advisor)	217	None

Name and Year of Birth	Position and Offices with Trust	Term of Office and Length of Service	Principal Occupations During Past 5 Years
OFFICERS⁽²⁾
James M. Dykas (1966)	President and Chief Executive Officer	• Indefinite Term • Since January 2016	Managing Director and Chief Financial Officer, First Trust Advisors L.P. and First Trust Portfolios L.P.; Chief Financial Officer, BondWave LLC (Software Development Company) and Stonebridge Advisors LLC (Investment Advisor)
Donald P. Swade (1972)	Treasurer, Chief Financial Officer and Chief Accounting Officer	• Indefinite Term • Since January 2016	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.
W. Scott Jardine (1960)	Secretary and Chief Legal Officer	• Indefinite Term • Since Inception	General Counsel, First Trust Advisors L.P. and First Trust Portfolios L.P.; Secretary and General Counsel, BondWave LLC; Secretary, Stonebridge Advisors LLC
Daniel J. Lindquist (1970)	Vice President	• Indefinite Term • Since Inception	Managing Director, First Trust Advisors L.P. and First Trust Portfolios L.P.
Kristi A. Maher (1966)	Chief Compliance Officer and Assistant Secretary	• Indefinite Term • Since Inception	Deputy General Counsel, First Trust Advisors L.P. and First Trust Portfolios L.P.

Roger F. Testin (1966)	Vice President	• Indefinite Term • Since Inception	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.
Stan Ueland (1970)	Vice President	• Indefinite Term • Since Inception	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.

⁽¹⁾	Mr. Bowen is deemed an “interested person” of the Trust due to his position as CEO of First Trust Advisors L.P., investment advisor of the Trust.

⁽²⁾	The term “officer” means the president, vice president, secretary, treasurer, controller or any other officer who performs a policy making function.

Page 67

Table of Contents

First Trust Exchange-Traded Fund VI

March 31, 2022 (Unaudited)

First Trust values our relationship with you and considers your privacy an important priority in maintaining that relationship. We are committed to protecting the security and confidentiality of your personal information.

Sources of Information

We collect nonpublic personal information about you from the following sources:

•	Information we receive from you and your broker-dealer, investment professional or financial representative through interviews, applications, agreements or other forms;
•	Information about your transactions with us, our affiliates or others;
•	Information we receive from your inquiries by mail, e-mail or telephone; and
•	Information we collect on our website through the use of “cookies”. For example, we may identify the pages on our website that your browser requests or visits.

Information Collected

The type of data we collect may include your name, address, social security number, age, financial status, assets, income, tax information, retirement and estate plan information, transaction history, account balance, payment history, investment objectives, marital status, family relationships and other personal information.

Disclosure of Information

We do not disclose any nonpublic personal information about our customers or former customers to anyone, except as permitted by law. In addition to using this information to verify your identity (as required under law), the permitted uses may also include the disclosure of such information to unaffiliated companies for the following reasons:

•

In order to provide you with products and services and to effect transactions that you request or authorize, we may disclose your personal information as described above to unaffiliated financial service providers and other companies that perform administrative or other services on our behalf, such as transfer agents, custodians and trustees, or that assist us in the distribution of investor materials such as trustees, banks, financial representatives, proxy services, solicitors and printers.

•

We may release information we have about you if you direct us to do so, if we are compelled by law to do so, or in other legally limited circumstances (for example to protect your account from fraud).

In addition, in order to alert you to our other financial products and services, we may share your personal information within First Trust.

Use of Website Analytics

We currently use third party analytics tools, Google Analytics and AddThis, to gather information for purposes of improving First Trust’s website and marketing our products and services to you. These tools employ cookies, which are small pieces of text stored in a file by your web browser and sent to websites that you visit, to collect information, track website usage and viewing trends such as the number of hits, pages visited, videos and PDFs viewed and the length of user sessions in order to evaluate website performance and enhance navigation of the website. We may also collect other anonymous information, which is generally limited to technical and web navigation information such as the IP address of your device, internet browser type and operating system for purposes of analyzing the data to make First Trust’s website better and more useful to our users. The information collected does not include any personal identifiable information such as your name, address, phone number or email address unless you provide that information through the website for us to contact you in order to answer your questions or respond to your requests. To find out how to opt-out of these services click on: Google Analytics and AddThis.

Confidentiality and Security

With regard to our internal security procedures, First Trust restricts access to your nonpublic personal information to those First Trust employees who need to know that information to provide products or services to you. We maintain physical, electronic and procedural safeguards to protect your nonpublic personal information.

Policy Updates and Inquiries

As required by federal law, we will notify you of our privacy policy annually. We reserve the right to modify this policy at any time, however, if we do change it, we will tell you promptly. For questions about our policy, or for additional copies of this notice, please go to www.ftportfolios.com, or contact us at 1-800-621-1675 (First Trust Portfolios) or 1-800-222-6822 (First Trust Advisors).

March 2022

Page 68

Shareholder Letter	2
Market Overview	3
Fund Performance Overview
First Trust Nasdaq Bank ETF (FTXO)	4
First Trust Nasdaq Food & Beverage ETF (FTXG)	6
First Trust Nasdaq Oil & Gas ETF (FTXN)	8
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	10
First Trust S-Network E-Commerce ETF (ISHP)	12
First Trust Nasdaq Semiconductor ETF (FTXL)	14
First Trust Nasdaq Transportation ETF (FTXR)	16
First Trust S-Network Streaming & Gaming ETF (BNGE)	18
Notes to Fund Performance Overview	20
Understanding Your Fund Expenses	21
Portfolio of Investments
First Trust Nasdaq Bank ETF (FTXO)	23
First Trust Nasdaq Food & Beverage ETF (FTXG)	24
First Trust Nasdaq Oil & Gas ETF (FTXN)	25
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	26
First Trust S-Network E-Commerce ETF (ISHP)	27
First Trust Nasdaq Semiconductor ETF (FTXL)	29
First Trust Nasdaq Transportation ETF (FTXR)	30
First Trust S-Network Streaming & Gaming ETF (BNGE)	32
Statements of Assets and Liabilities	34
Statements of Operations	36
Statements of Changes in Net Assets	38
Financial Highlights	42
Notes to Financial Statements	50
Report of Independent Registered Public Accounting Firm	59
Additional Information	61
Board of Trustees and Officers	66
Privacy Policy	68

First Trust Nasdaq Pharmaceuticals ETF (FTXH)	First Trust S-Network E-Commerce ETF (ISHP)	First Trust Nasdaq Semiconductor ETF (FTXL)	First Trust Nasdaq Transportation ETF (FTXR)	First Trust S-Network Streaming & Gaming ETF (BNGE)

$ 17,289,855	$ 18,547,013	$ 108,250,992	$ 289,100,635	$ 3,474,706
1,227	37,258	228,878	703,605	14,352
—	1,327	—	—	—

—	—	3,570,002	—	—
28,569	5,676	16,307	400,467	4,849
287	4,505	—	79	—
—	—	—	239,789	—
—	—	—	6,434,119	—
17,319,938	18,595,779	112,066,179	296,878,694	3,493,907


—	—	3,563,137	—	—
8,608	9,377	52,339	333,553	2,050
—	—	—	9,247,285	—
—	—	—	6,456,130	—
8,608	9,377	3,615,476	16,036,968	2,050
$ 17,311,330	$ 18,586,402	$ 108,450,703	$ 280,841,726	$ 3,491,857

$ 17,967,076	$ 23,661,578	$ 114,586,523	$ 330,661,988	$ 3,658,817
6,500	6,000	15,500	87,000	1,500
(662,246)	(5,081,176)	(6,151,320)	(49,907,262)	(168,460)
$ 17,311,330	$ 18,586,402	$ 108,450,703	$ 280,841,726	$ 3,491,857
$26.63	$30.98	$69.97	$32.28	$23.28
650,002	600,002	1,550,002	8,700,002	150,002
$15,705,794	$20,395,040	$107,226,769	$301,870,012	$3,645,431
$—	$1,328	$—	$—	$—
$—	$—	$—	$8,968,935	$—

First Trust Nasdaq Oil & Gas ETF (FTXN)		First Trust Nasdaq Pharmaceuticals ETF (FTXH)		First Trust S-Network E-Commerce ETF (ISHP)
Year Ended 3/31/2022	Year Ended 3/31/2021	Year Ended 3/31/2022	Year Ended 3/31/2021	Year Ended 3/31/2022	Year Ended 3/31/2021

$ 6,902,387	$ 385,232	$ 185,875	$ 172,248	$ 174,149	$ 40,918
170,957,349	4,201,224	387,327	1,413,284	359,766	765,555
162,037,630	5,482,034	444,270	2,106,357	(2,624,610)	1,880,553
339,897,366	10,068,490	1,017,472	3,691,889	(2,090,695)	2,687,026

(6,320,716)	(342,435)	(176,100)	(161,361)	(143,821)	(41,275)

1,655,064,859	37,358,049	2,582,284	20,157,542	36,521,440	8,716,861
(877,458,299)	(17,521,673)	(5,245,253)	(10,364,671)	(25,144,637)	(5,537,780)
777,606,560	19,836,376	(2,662,969)	9,792,871	11,376,803	3,179,081
1,111,183,210	29,562,431	(1,821,597)	13,323,399	9,142,287	5,824,832

36,447,762	6,885,331	19,132,927	5,809,528	9,444,115	3,619,283
$1,147,630,972	$36,447,762	$17,311,330	$19,132,927	$18,586,402	$9,444,115

2,350,002	850,002	750,002	300,002	300,002	200,002
76,750,000	2,750,000	100,000	850,000	1,050,000	300,000
(35,750,000)	(1,250,000)	(200,000)	(400,000)	(750,000)	(200,000)
43,350,002	2,350,002	650,002	750,002	600,002	300,002