First Trust Exchange-Traded Fund VI

Semi-Annual Report

September 30, 2021

Shareholder Letter	2
Market Overview	3
Fund Performance Overview
Developed International Equity Select ETF (RNDM)	4
Emerging Markets Equity Select ETF (RNEM)	6
Large Cap US Equity Select ETF (RNLC)	8
Mid Cap US Equity Select ETF (RNMC)	10
Small Cap US Equity Select ETF (RNSC)	12
US Equity Dividend Select ETF (RNDV)	14
Notes to Fund Performance Overview	16
Understanding Your Fund Expenses	17
Portfolio of Investments
Developed International Equity Select ETF (RNDM)	18
Emerging Markets Equity Select ETF (RNEM)	25
Large Cap US Equity Select ETF (RNLC)	31
Mid Cap US Equity Select ETF (RNMC)	37
Small Cap US Equity Select ETF (RNSC)	43
US Equity Dividend Select ETF (RNDV)	50
Statements of Assets and Liabilities	54
Statements of Operations	56
Statements of Changes in Net Assets	58
Financial Highlights	60
Notes to Financial Statements	66
Additional Information	75

Caution Regarding Forward-Looking Statements

This report contains certain forward-looking statements within the meaning of the Securities Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended. Forward-looking statements include statements regarding the goals, beliefs, plans or current expectations of First Trust Advisors L.P. (“First Trust” or the “Advisor”) and its representatives, taking into account the information currently available to them. Forward-looking statements include all statements that do not relate solely to current or historical fact. For example, forward-looking statements include the use of words such as “anticipate,” “estimate,” “intend,” “expect,” “believe,” “plan,” “may,” “should,” “would” or other words that convey uncertainty of future events or outcomes.

Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results, performance or achievements of any series of First Trust Exchange-Traded Fund VI (the “Trust”) described in this report (each such series is referred to as a “Fund” and collectively, the “Funds”) to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. When evaluating the information included in this report, you are cautioned not to place undue reliance on these forward-looking statements, which reflect the judgment of the Advisor and its representatives only as of the date hereof. We undertake no obligation to publicly revise or update these forward-looking statements to reflect events and circumstances that arise after the date hereof.

Performance and Risk Disclosure

There is no assurance that any Fund described in this report will achieve its investment objective. Each Fund is subject to market risk, which is the possibility that the market values of securities owned by the Fund will decline and that the value of the Fund’s shares may therefore be less than what you paid for them. Accordingly, you can lose money by investing in a Fund. See “Risk Considerations” in the Additional Information section of this report for a discussion of certain other risks of investing in the Funds.

Performance data quoted represents past performance, which is no guarantee of future results, and current performance may be lower or higher than the figures shown. For the most recent month-end performance figures, please visit www.ftportfolios.com or speak with your financial advisor. Investment returns, net asset value and share price will fluctuate and Fund shares, when sold, may be worth more or less than their original cost.

The Advisor may also periodically provide additional information on Fund performance on each Fund’s web page at www.ftportfolios.com.

How to Read This Report

This report contains information that may help you evaluate your investment. It includes details about each Fund and presents data and analysis that provide insight into each Fund’s performance and investment approach.

By reading the market overview by Robert F. Carey, Chief Market Strategist of the Advisor, you may obtain an understanding of how the market environment affected the performance of each Fund. The statistical information that follows may help you understand each Fund’s performance compared to that of relevant market benchmarks.

It is important to keep in mind that the opinions expressed by personnel of the Advisor are just that: informed opinions. They should not be considered to be promises or advice. The opinions, like the statistics, cover the period through the date on the cover of this report. The material risks of investing in each Fund are spelled out in the prospectus, the statement of additional information, and other Fund regulatory filings.

Page 1

First Trust Exchange-Traded Fund VI

Semi-Annual Letter from the Chairman and CEO

September 30, 2021

Dear Shareholders,

First Trust is pleased to provide you with the semi-annual report for certain series of the First Trust Exchange-Traded Fund VI (the “Funds”), which contains detailed information about the Funds for the six months ended September 30, 2021.

A great deal has changed over the past 18 months. Suffice it to say that the dominant story in 2020 was the onset of the coronavirus (“COVID-19”) pandemic. It is still a huge story 20 months later, mostly due to the arrival of the Delta variant in the U.S. and the subsequent surge in cases around mid-2021. The Delta variant is twice as contagious as the previous variants, according to the Centers for Disease Control and Prevention (“CDC”). Fortunately, we have come to learn that the existing vaccines approved by the U.S. Food and Drug Administration have been effective in providing protection against the Delta variant, particularly with respect to keeping the people already vaccinated out of the intensive care unit. As I’m sure you are aware, a significant percentage of the U.S. population has chosen not to be vaccinated. These individuals have proven to be much more vulnerable to the virus and account for the lion’s share of hospitalizations, according to the CDC. While it is these individuals right to choose, unless mandated by a private company or government agency, the universe of people that have not gotten vaccinated is large enough that it has likely delayed the full economic recovery, at least on the margin, in our opinion. In the U.S., the path chosen by the federal government to help mitigate the economic fallout from the pandemic has been to inject trillions of dollars of liquidity (stimulus) into the financial system. To date, it appears to have been effective, however, it has contributed to a new and potentially ominous headwind for the economy: inflation.

The Consumer Price Index came in at 5.4% year-over-year in September 2021, the largest increase since 2008, according to data from the Bureau of Labor Statistics (“BLS”). The BLS also reported that the Producer Price Index was up 8.6% compared to a year ago, its highest level since 1981. These two barometers of inflation are clearly elevated. Why is rising inflation worth noting? It tends to reduce the purchasing power of the currency one uses over time. In the case of the U.S., it reduces how much consumers can buy with their dollars. A modest amount of inflation can be a sign that the economy is healthy. Too much inflation can derail an economy. While we are not even close to that point yet, investors should monitor the direction of inflation moving forward because the U.S. economy has yet to fully reopen from the COVID-19 pandemic and millions of workers remain on the sideline. Earlier this year, Federal Reserve Chairman Jerome Powell proclaimed that the spike in inflation in the U.S. would be relatively short-lived, or “transitory.” He cited the pandemic-related bottlenecks in the global supply chain for creating shortages in such critical industries as semiconductors as being largely responsible for the sharp rise in prices. With prices rising nearly across the board, his take on inflation is losing credibility with each passing month, in my opinion. If inflation continues to run hotter-than-expected, we believe that the Federal Reserve will likely have to alter its easy monetary policy in favor of one that boosts interest rates and bond yields.

The markets have performed quite well over the past 18 months. I believe that the combination of the federal government’s efforts in fast-tracking the vaccines, its decisiveness in injecting trillions of dollars of capital into the financial system to help backstop it, and the ability of millions of workers to adapt to working efficiently from home helped boost the confidence levels of investors throughout. Having said that, I still feel we need to fully reopen the U.S. economy, put the millions of people out of work back to work and remedy the global supply chain bottlenecks. While investors should be prepared for the possibility of some additional volatility moving forward, due to inflationary pressures, the potential for higher interest rates and bond yields, and next year’s mid-term election season, we encourage them to stay the course.

Thank you for giving First Trust the opportunity to play a role in your financial future. We value our relationship with you and will report on the Funds again in six months.

Sincerely,

James A. Bowen

Chairman of the Board of Trustees

Chief Executive Officer of First Trust Advisors L.P.

Page 2

First Trust Exchange-Traded Fund VI

Semi-Annual Report

September 30, 2021

Robert F. Carey, CFA

Senior Vice President and Chief Market Strategist

First Trust Advisors L.P.

Mr. Carey is responsible for the overall management of research and analysis of the First Trust product line. Mr. Carey has more than 30 years of experience as an Equity and Fixed-Income Analyst and is a recipient of the Chartered Financial Analyst (“CFA”) designation. He is a graduate of the University of Illinois at Champaign-Urbana with a B.S. in Physics. He is also a member of the Investment Analysts Society of Chicago and the CFA Institute. Mr. Carey has appeared as a guest on such programs as Bloomberg TV, CNBC, and WBBM Radio, and has been quoted by several publications, including The Wall Street Journal, The Wall Street Reporter, Bloomberg News Service, and Registered Rep.

State of the Global Economy

The International Monetary Fund (“IMF”) reported in its latest release that global gross domestic product (“GDP”) growth is expected to come in at 5.9% in 2021 and 4.9% in 2022, up from -3.1% in 2020. Keep in mind that the onset of the coronavirus (“COVID-19”) pandemic in the U.S. and most global regions occurred in the first quarter of 2020. The IMF sees the U.S. economy growing at 6.0% in 2021 and 5.2% in 2022, up from -3.4% in 2020. With respect to all Advanced Economies, the IMF is projecting GDP growth of 5.2% in 2021 and 4.5% in 2022, up from -4.5% in 2020. Lastly, the IMF projects Emerging Market and Developing Economies to grow at a rate of 6.4% in 2021 and 5.1% in 2022, up from -2.1% in 2020. Looking ahead to 2022, the outlook for growth is encouraging, but down a bit from the strong pandemic-induced recovery in 2021. The IMF is concerned that inflationary pressures stemming from the global supply chain bottlenecks could push prices higher if the problems persist. That scenario could, in turn, cause central banks to raise rates quickly to try and prevent inflation from overheating.

One of the better barometers for judging the overall business climate is mergers and acquisitions (“M&A”) activity, in our opinion. M&A deals totaled $4.3 trillion over the first nine months of 2021, the most ever recorded for that period, according to data from Refinitiv. The $1.52 trillion in deal value registered in the third quarter of 2021 was the highest ever for a calendar quarter. Executives are expanding their businesses aggressively in the current climate. 

Global Equities Markets

With respect to U.S. equities, the S&P 500^®, S&P MidCap 400^®, and S&P SmallCap 600^® Indices posted total returns of 9.18%, 1.81% and 1.54%, respectively, for the six-month period ended September 30, 2021. Large-capitalization (“cap”) stocks significantly outperformed their mid- and small-cap counterparts in the period. Investors may have favored well-capitalized companies in the period due to the surge in the volume of Delta variant cases of COVID-19, in our opinion. All 11 sectors that comprise the S&P 500^® Index were up on a total return basis. The top performer was the Real Estate sector, up 14.08%, while the worst result came from the Industrials sector, up 0.06%.

A Bloomberg survey of 21 equity strategists found that their average 2021 year-end price target for the S&P 500^® Index was 4,466 as of September 21, 2021, up from 4,335 on August 20, 2021, according to its own release. The highest and lowest estimates were 4,825 (up from 4,700) and 3,800 (unchanged), respectively. On September 30, 2021, the S&P 500^® Index closed at 4,307.54, which was 5.06% below its all-time closing high of 4,536.95 on September 2, 2021. As of October 1, 2021, Bloomberg’s 2021, 2022 and 2023 consensus earnings growth rate estimates for the S&P 500^® Index stood at 44.90%, 8.95% and 9.80%, respectively.

Over the past six months, the MSCI World ex USA and MSCI Emerging Markets Indices posted total returns of 4.95% (USD) and -3.45% (USD), respectively, according to Bloomberg. The Bloomberg Global Aggregate Index of higher quality debt posted a total return of 0.42% (USD), while the Bloomberg EM Hard Currency Aggregate Index of emerging markets debt rose by 1.99% (USD), according Bloomberg. Over that same period, the U.S. dollar rose by 1.07% against a basket of major currencies, as measured by the U.S. Dollar Index (DXY). The modest increase in the dollar had little impact on the performance of these foreign indices, in our opinion.

In the U.S. bond market, the top-performing major debt group we track was high yield corporate bonds. The Bloomberg U.S. Corporate High Yield Index posted a total return of 3.65% for the six-month period ended September 30, 2021. The worst-performing U.S. debt group that we track was long maturity Government National Mortgage Association (“GNMAs”). The Bloomberg GNMA 30-Year Index posted a total return of -0.02%. The yield on the benchmark 10-Year Treasury Note (“T-Note”) increased by 25 points in the period to close at 1.49% on September 30, 2021, according to Bloomberg. For comparative purposes, the average yield on the 10-Year T-Note was 2.04% for the 10-year period ended September 30, 2021.

Page 3

Developed International Equity Select ETF (RNDM)

The Developed International Equity Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze Developed Markets Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNDM.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks, depositary receipts, preferred shares and real estate investment trusts that comprise the Index.

The Index is designed to select low volatility developed markets (excluding the United States) securities that are included in the NASDAQ Developed Markets Ex-US Large Mid Cap Index (the “Base Index”) and have a minimum three-month average daily dollar trading volume of $5 million. The Base Index is a comprehensive, rules-based index designed to measure stock market performance of companies in developed markets (excluding the United States), as determined by Nasdaq, Inc. A country is classified as “developed” based on a number of criteria including national income per capita, national market capitalization and national trading volume. Companies are classified as operating in a country primarily by their country of incorporation, domicile and primary exchange listing.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	3.85%	16.98%	4.32%	19.83%
Market Price	3.75%	17.71%	4.39%	20.19%
Index Performance
Nasdaq Riskalyze Developed Markets Index	4.66%	18.72%	5.68%	26.68%
NASDAQ Developed Markets Ex-US Large Mid Cap Index(1)	4.72%	26.95%	8.12%	39.65%
MSCI World ex USA Index(1)	4.95%	26.50%	7.48%	36.17%

(See Notes to Fund Performance Overview on page 16.)

(1)

As previously disclosed and consistent with the Fund’s return objective, the NASDAQ Developed Markets Ex-US Large Mid Cap Index will be used as the Fund’s benchmark for performance attribution purposes. The MSCI World ex USA Index was previously used as the Fund’s benchmark for performance purposes. The Nasdaq Riskalyze Developed Markets Index, the Fund’s underlying index, is derived from the NASDAQ Developed Markets Ex-US Large Mid Cap Index. As such, the Advisor has determined to measure the Fund’s relative outperformance and underperformance against the parent index, NASDAQ Developed Markets Ex-US Large Mid Cap Index, going forward. The MSCI World ex USA Index is reflected above for additional performance comparison purposes.

Riskalyze and Nasdaq Riskalyze Developed Markets Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 4

Developed International Equity Select ETF (RNDM) (Continued)

Sector Allocation	% of Total Investments
Financials	20.3%
Industrials	20.1
Consumer Staples	12.1
Health Care	10.6
Information Technology	9.3
Communication Services	7.3
Materials	6.5
Consumer Discretionary	4.9
Utilities	4.0
Real Estate	2.8
Energy	2.1
Total	100.0%

Top Ten Holdings	% of Total Investments
Itochu Techno-Solutions Corp.	3.0%
MS&AD Insurance Group Holdings, Inc.	2.5
Admiral Group PLC	2.4
RELX PLC	2.0
Croda International PLC	1.9
Roche Holding AG	1.8
Henkel AG & Co., KGaA (Preference Shares)	1.6
Novartis AG	1.5
Enbridge, Inc.	1.4
Mitsubishi Corp.	1.3
Total	19.4%

Page 5

Emerging Markets Equity Select ETF (RNEM)

The Emerging Markets Equity Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze Emerging Markets Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNEM.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks, depository receipts, preferred shares and real estate investment trusts that comprise the Index.

The Index is designed to select low volatility emerging markets securities that are included in the NASDAQ Emerging Markets Large Mid Cap Index (the “Base Index”) and have a minimum three-month average daily dollar trading volume of $5 million. The Base Index is a comprehensive, rules-based index designed to measure stock market performance of companies in emerging markets, as determined by Nasdaq, Inc. A country is classified as “emerging” based on a number of criteria including national income per capita, national market capitalization and national trading volume. Emerging markets are generally characterized by lower market efficiency and less strict standards in accounting and securities regulation than developed markets. Companies are classified as operating in a country primarily by their country of incorporation, domicile and primary exchange listing.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	0.65%	21.63%	2.62%	11.73%
Market Price	-0.06%	21.66%	2.65%	11.82%
Index Performance
Nasdaq Riskalyze Emerging Markets Index	2.79%	26.14%	4.81%	22.26%
NASDAQ Emerging Markets Large Mid Cap Index(1)	-2.11%	18.64%	7.81%	37.94%
MSCI Emerging Markets Index(1)	-3.45%	18.20%	7.76%	37.69%

(See Notes to Fund Performance Overview on page 16.)

(1)

As previously disclosed and consistent with the Fund’s return objective, the NASDAQ Emerging Markets Large Mid Cap Index will be used as the Fund’s benchmark for performance attribution purposes. The MSCI Emerging Markets Index was previously used as the Fund’s benchmark for performance purposes. The Nasdaq Riskalyze Emerging Markets Index, the Fund’s underlying index, is derived from the NASDAQ Emerging Markets Large Mid Cap Index. As such, the Advisor has determined to measure the Fund’s relative outperformance and underperformance against the parent index, NASDAQ Emerging Markets Large Mid Cap Index, going forward. The MSCI Emerging Markets Index is reflected above for additional performance comparison purposes.

Riskalyze and Nasdaq Riskalyze Emerging Markets Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 6

Emerging Markets Equity Select ETF (RNEM) (Continued)

Sector Allocation	% of Total Investments
Financials	27.3%
Materials	15.6
Information Technology	14.9
Consumer Staples	11.8
Industrials	6.2
Consumer Discretionary	5.7
Communication Services	4.5
Utilities	3.8
Real Estate	3.5
Health Care	3.4
Energy	3.3
Total	100.0%

Top Ten Holdings	% of Total Investments
WPG Holdings Ltd.	3.1%
Infosys Ltd.	3.1
Tata Consultancy Services Ltd.	3.0
Inventec Corp.	3.0
Compal Electronics, Inc.	2.7
China Steel Corp.	2.3
Naspers Ltd., Class N	2.0
Want Want China Holdings Ltd.	1.7
Pidilite Industries Ltd.	1.6
Hengan International Group Co., Ltd.	1.4
Total	23.9%

Page 7

Large Cap US Equity Select ETF (RNLC)

The Large Cap US Equity Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze US Large Cap Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNLC.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks and real estate investment trusts that comprise the Index.

The Index is designed to select dividend-paying US large cap securities that are included in the Nasdaq US 500 Large Cap Index^TM (the “Base Index”) and have paid a dividend in the trailing twelve months (based on ex-date). The Base Index is a comprehensive, rules-based index designed to measure stock market performance of large cap US companies, as determined by Nasdaq, Inc.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	6.05%	34.74%	13.47%	71.73%
Market Price	5.94%	34.90%	13.48%	71.78%
Index Performance
Nasdaq Riskalyze US Large Cap Index	6.37%	35.62%	14.18%	76.39%
Nasdaq US 500 Large Cap IndexTM	9.11%	29.16%	16.81%	94.45%
S&P 500® Index	9.18%	30.00%	16.36%	91.26%

(See Notes to Fund Performance Overview on page 16.)

Riskalyze and Nasdaq Riskalyze US Large Cap Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 8

Large Cap US Equity Select ETF (RNLC) (Continued)

Sector Allocation	% of Total Investments
Information Technology	30.8%
Health Care	13.7
Industrials	11.8
Financials	11.4
Consumer Discretionary	11.3
Consumer Staples	5.9
Communication Services	4.8
Energy	2.8
Materials	2.7
Real Estate	2.6
Utilities	2.2
Total	100.0%

Top Ten Holdings	% of Total Investments
Monolithic Power Systems, Inc.	1.1%
Oracle Corp.	0.9
Intuit, Inc.	0.9
NetApp, Inc.	0.9
Cognizant Technology Solutions Corp., Class A	0.9
Amphenol Corp., Class A	0.9
CDW Corp.	0.9
Microsoft Corp.	0.9
NVIDIA Corp.	0.9
Marvell Technology, Inc.	0.9
Total	9.2%

Page 9

Mid Cap US Equity Select ETF (RNMC)

The Mid Cap US Equity Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze US Mid Cap Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNMC.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks and real estate investment trusts that comprise the Index.

The Index is designed to select dividend-paying US mid cap securities that are included in the Nasdaq US 600 Mid Cap Index™ (the “Base Index”) and have paid a dividend in the trailing twelve months (based on ex-date). The Base Index is a comprehensive, rules-based index designed to measure stock market performance of mid cap US companies, as determined by Nasdaq, Inc.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	3.26%	47.40%	10.51%	53.37%
Market Price	3.55%	48.07%	10.60%	53.90%
Index Performance
Nasdaq Riskalyze US Mid Cap Index	3.55%	48.36%	11.18%	57.38%
Nasdaq US 600 Mid Cap IndexTM	2.56%	41.97%	13.88%	74.40%
S&P MidCap 400® Index	1.81%	43.68%	11.90%	61.80%

(See Notes to Fund Performance Overview on page 16.)

Riskalyze and Nasdaq Riskalyze US Mid Cap Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 10

Mid Cap US Equity Select ETF (RNMC) (Continued)

Sector Allocation	% of Total Investments
Industrials	15.8%
Financials	15.3
Consumer Discretionary	14.6
Health Care	12.4
Information Technology	11.6
Real Estate	9.1
Materials	6.8
Utilities	4.3
Energy	3.7
Consumer Staples	3.4
Communication Services	3.0
Total	100.0%

Top Ten Holdings	% of Total Investments
Hill-Rom Holdings, Inc.	1.8%
Premier, Inc., Class A	1.5
Perrigo Co. PLC	1.4
Bruker Corp.	1.4
Chemed Corp.	1.3
Encompass Health Corp.	1.3
Universal Health Services, Inc., Class B	1.3
DENTSPLY SIRONA, Inc.	1.2
Ensign Group (The), Inc.	1.2
Power Integrations, Inc.	0.9
Total	13.3%

Page 11

Small Cap US Equity Select ETF (RNSC)

The Small Cap US Equity Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze US Small Cap Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNSC.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks and real estate investment trusts that comprise the Index.

The Index is designed to select dividend-paying US small cap securities that are included in the Nasdaq US 700 Small Cap Index^TM (the “Base Index”) and have paid a dividend in the trailing twelve months (based on ex-date). The Base Index is a comprehensive, rules-based index designed to measure stock market performance of small cap US companies, as determined by Nasdaq, Inc.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	0.27%	55.65%	10.41%	52.76%
Market Price	0.17%	55.84%	10.45%	53.02%
Index Performance
Nasdaq Riskalyze US Small Cap Index	0.55%	56.82%	11.15%	57.23%
Nasdaq US 700 Small Cap IndexTM	0.49%	57.35%	14.31%	77.27%
S&P SmallCap 600® Index	1.54%	57.64%	12.77%	67.27%

(See Notes to Fund Performance Overview on page 16.)

Riskalyze and Nasdaq Riskalyze US Small Cap Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 12

Small Cap US Equity Select ETF (RNSC) (Continued)

Sector Allocation	% of Total Long-Term Investments
Financials	19.3%
Industrials	19.0
Consumer Discretionary	12.9
Health Care	12.0
Information Technology	9.0
Real Estate	7.9
Materials	5.2
Consumer Staples	3.8
Energy	3.8
Communication Services	3.7
Utilities	3.4
Total	100.0%

Top Ten Holdings	% of Total Long-Term Investments
Atrion Corp.	1.9%
Patterson Cos., Inc.	1.7
U.S. Physical Therapy, Inc.	1.6
CONMED Corp.	1.6
National Research Corp.	1.6
Select Medical Holdings Corp.	1.4
Healthcare Services Group, Inc.	1.3
Owens & Minor, Inc.	1.2
Switch, Inc., Class A	1.1
Shutterstock, Inc.	1.1
Total	14.5%

Page 13

US Equity Dividend Select ETF (RNDV)

The US Equity Dividend Select ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq Riskalyze US Large Cap Select Dividend Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “RNDV.” The Fund normally invests at least 90% of its net assets (including investment borrowings) in the common stocks and real estate investment trusts that comprise the Index.

The Index is designed to select dividend-paying US securities that (i) are included in the Nasdaq US 500 Large Cap Index^TM (the “Base Index”); (ii) have paid a dividend in the trailing twelve months (based on the ex-date); and (iii) have a trailing twelve-month dividend yield higher than the index yield of the Base Index. The Base Index is a comprehensive, rules-based index designed to measure stock market performance of large cap US companies, as determined by Nasdaq, Inc.

Performance
			Average Annual Total Returns	Cumulative Total Returns
	6 Months Ended 9/30/21	1 Year Ended 9/30/21	Inception (6/20/17) to 9/30/21	Inception (6/20/17) to 9/30/21
Fund Performance
NAV	3.17%	36.75%	12.08%	62.92%
Market Price	3.10%	37.20%	12.08%	62.93%
Index Performance
Nasdaq Riskalyze US Large Cap Select Dividend Index	3.43%	37.54%	12.71%	66.85%
Nasdaq US 500 Large Cap IndexTM	9.11%	29.16%	16.81%	94.45%
S&P 500® Index	9.18%	30.00%	16.36%	91.26%

(See Notes to Fund Performance Overview on page 16.)

Riskalyze and Nasdaq Riskalyze US Large Cap Select Dividend Index are trademarks or service marks of Riskalyze, Inc. (“Riskalyze”) and have been licensed for use for certain purposes by First Trust. The Fund is not sponsored, endorsed, sold or promoted by Riskalyze, and Riskalyze makes no representation regarding the advisability of trading in the Fund.

Page 14

US Equity Dividend Select ETF (RNDV) (Continued)

Sector Allocation	% of Total Investments
Information Technology	29.8%
Health Care	13.3
Consumer Discretionary	12.0
Industrials	11.6
Financials	11.5
Communication Services	6.1
Consumer Staples	5.8
Energy	2.8
Real Estate	2.6
Utilities	2.3
Materials	2.2
Total	100.0%

Top Ten Holdings	% of Total Investments
International Business Machines Corp.	3.5%
Hewlett Packard Enterprise Co.	2.7
Broadcom, Inc.	2.5
Seagate Technology Holdings PLC	2.3
NetApp, Inc.	2.1
Omnicom Group, Inc.	2.0
Intel Corp.	1.9
HP, Inc.	1.9
Hasbro, Inc.	1.7
Texas Instruments, Inc.	1.7
Total	22.3%

Page 15

Total returns for the period since inception are calculated from the inception date of each Fund. “Average Annual Total Returns” represent the average annual change in value of an investment over the periods indicated. “Cumulative Total Returns” represent the total change in value of an investment over the periods indicated.

Each Fund’s per share net asset value (“NAV”) is the value of one share of the Fund and is computed by dividing the value of all assets of the Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of outstanding shares. The price used to calculate market return (“Market Price”) is determined by using the midpoint of the national best bid and offer price (“NBBO”) as of the time that the Fund’s NAV is calculated. Under SEC rules, the NBBO consists of the highest displayed buy and lowest sell prices among the various exchanges trading the Fund at the time the Fund’s NAV is calculated. Prior to January 1, 2019, the price used was the midpoint between the highest bid and the lowest offer on the stock exchange on which shares of the Fund were listed for trading as of the time that the Fund’s NAV was calculated. Since shares of each Fund did not trade in the secondary market until after the Fund’s inception, for the period from inception to the first day of secondary market trading in shares of the Fund, the NAV of each Fund is used as a proxy for the secondary market trading price to calculate market returns. NAV and market returns assume that all distributions have been reinvested in each Fund at NAV and Market Price, respectively.

An index is a statistical composite that tracks a specified financial market or sector. Unlike each Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by each Fund. These expenses negatively impact the performance of each Fund. Also, market returns do not include brokerage commissions that may be payable on secondary market transactions. If brokerage commissions were included, market returns would be lower. The total returns presented reflect the reinvestment of dividends on securities in the indices. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. The investment return and principal value of shares of each Fund will vary with changes in market conditions. Shares of each Fund may be worth more or less than their original cost when they are redeemed or sold in the market. Each Fund’s past performance is no guarantee of future performance.

Page 16

First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses

September 30, 2021 (Unaudited)

As a shareholder of Developed International Equity Select ETF, Emerging Markets Equity Select ETF, Large Cap US Equity Select ETF, Mid Cap US Equity Select ETF, Small Cap US Equity Select ETF or US Equity Dividend Select ETF (each a “Fund” and collectively, the “Funds”), you incur two types of costs: (1) transaction costs; and (2) ongoing costs, including management fees, distribution and/or service (12b-1) fees, if any, and other Fund expenses. This Example is intended to help you understand your ongoing costs of investing in the Funds and to compare these costs with the ongoing costs (in U.S. dollars) of investing in other funds.

The Example is based on an investment of $1,000 invested at the beginning of the period and held through the six-month period ended September 30, 2021.

Actual Expenses

The first line in the following table provides information about actual account values and actual expenses. You may use the information in this line, together with the amount you invested, to estimate the expenses that you paid over the period. Simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number in the first line under the heading entitled “Expenses Paid During the Six-Month Period” to estimate the expenses you paid on your account during this six-month period.

Hypothetical Example for Comparison Purposes

The second line in the following table provides information about hypothetical account values and hypothetical expenses based on each Fund’s actual expense ratio and an assumed rate of return of 5% per year before expenses, which is not each Fund’s actual return. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in the Funds and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs such as brokerage commissions. Therefore, the second line in the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

	Beginning Account Value April 1, 2021	Ending Account Value September 30, 2021	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
Developed International Equity Select ETF (RNDM)
Actual	$1,000.00	$1,038.50	0.65%	$3.32
Hypothetical (5% return before expenses)	$1,000.00	$1,021.81	0.65%	$3.29
Emerging Markets Equity Select ETF (RNEM)
Actual	$1,000.00	$1,006.50	0.75%	$3.77
Hypothetical (5% return before expenses)	$1,000.00	$1,021.31	0.75%	$3.80
Large Cap US Equity Select ETF (RNLC)
Actual	$1,000.00	$1,060.50	0.60%	$3.10
Hypothetical (5% return before expenses)	$1,000.00	$1,022.06	0.60%	$3.04
Mid Cap US Equity Select ETF (RNMC)
Actual	$1,000.00	$1,032.60	0.60%	$3.06
Hypothetical (5% return before expenses)	$1,000.00	$1,022.06	0.60%	$3.04
Small Cap US Equity Select ETF (RNSC)
Actual	$1,000.00	$1,002.70	0.60%	$3.01
Hypothetical (5% return before expenses)	$1,000.00	$1,022.06	0.60%	$3.04
US Equity Dividend Select ETF (RNDV)
Actual	$1,000.00	$1,031.70	0.50%	$2.55
Hypothetical (5% return before expenses)	$1,000.00	$1,022.56	0.50%	$2.54

    

(a)	Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (April 1, 2021 through September 30, 2021), multiplied by 183/365 (to reflect the six-month period).

Page 17

Developed International Equity Select ETF (RNDM)

Portfolio of Investments

September 30, 2021 (Unaudited)

Developed International Equity Select ETF (RNDM)

Portfolio of Investments (Continued)

September 30, 2021 (Unaudited)

Developed International Equity Select ETF (RNDM)

Portfolio of Investments (Continued)

September 30, 2021 (Unaudited)

Developed International Equity Select ETF (RNDM)

Portfolio of Investments (Continued)

September 30, 2021 (Unaudited)

Developed International Equity Select ETF (RNDM)

Portfolio of Investments (Continued)

September 30, 2021 (Unaudited)