Market Overview

First Trust Exchange-Traded Fund VI

Annual Report

March 31, 2023

Robert F. Carey, CFA

Senior Vice President and Chief Market Strategist

First Trust Advisors L.P.

Mr. Carey is responsible for the overall management of research and analysis of the First Trust product line. Mr. Carey has more than 30 years of experience as an Equity and Fixed-Income Analyst and is a recipient of the Chartered Financial Analyst (“CFA”) designation. He is a graduate of the University of Illinois at Champaign-Urbana with a B.S. in Physics. He is also a member of the Investment Analysts Society of Chicago and the CFA Institute. Mr. Carey has appeared as a guest on such programs as Bloomberg TV, CNBC, and WBBM Radio, and has been quoted by several publications, including The Wall Street Journal, The Wall Street Reporter, Bloomberg News Service, and Registered Rep.

State of the Global Economy

The latest global growth forecast from the International Monetary Fund (“IMF”) released in April 2023 sees real gross domestic product growth rising by 2.8% worldwide in 2023, down from its 2.9% projection in January 2023. The IMF is calling for a 1.6% growth rate for the U.S., up from its January 2023 estimate of 1.4%. Emerging Market and Developing Economies are expected to grow by 3.9% this year, down from the IMF’s 4.0% estimate in January 2023. The IMF notes that risks to their global outlook are squarely to the downside, especially given the recent turmoil in the Financials sector as well as stubbornly high inflation.

In the U.S., inflation, as measured by the Consumer Price Index (“CPI”), stood at 5.0% on a trailing 12-month basis at the end of March 2023, according to the U.S. Bureau of Labor Statistics. While this is significantly lower than the most recent high of 9.1% in June 2022, the CPI remains above its 30-year average of 2.5% as of March 31, 2023, and even further from the Federal Reserve’s (the “Fed”) target of 2.0%.

Performance of Global Stocks and Bonds

The major U.S. stock indices delivered negative results over the past 12 months. The S&P 500^® (the “Index”), S&P MidCap 400^® and S&P SmallCap 600^® Indices posted total returns of -7.73%, -5.12% and -8.82%, respectively, for the 12-month period ended March 31, 2023. Three of the 11 major sectors that comprise the Index were positive on a total return basis. The top performer was the Energy sector, up 13.63%, while the worst showing came from the Real Estate sector, down 19.75%.

A Bloomberg survey of twenty-four equity strategists found that their average 2023 year-end price target for the Index was 4,025, as of April 19, 2023, according to its own release. The highest and lowest estimates were 4,750 and 3,225, respectively. Brian Wesbury, Chief Economist at First Trust, announced in December 2022 that his 2023 year-end price target stood at 3,900. The Index closed trading on March 31, 2023 at 4,109. The outlook for corporate earnings in 2023 has turned negative. Bloomberg’s consensus year-over-year earnings growth rate estimates for the Index for the 2023 and 2024 calendar years stood at -2.67% and 11.56%, respectively, as of April 21, 2023.

The broader foreign stock indices experienced negative total returns over the past year. For the 12-months ended March 31, 2023, the MSCI World ex USA and MSCI Emerging Markets equity indices posted total returns of -2.74% (USD) and -10.70% (USD), respectively, according to Bloomberg. The major foreign bond indices were also down during the same period. The Bloomberg Global Aggregate Index of higher quality debt posted a total return of -8.07% (USD), while the Bloomberg EM Hard Currency Aggregate Index of emerging markets debt fell by 5.41% (USD), according to Bloomberg. The U.S. Dollar rose 4.27% over the past 12 months against a basket of major currencies, as measured by the U.S. Dollar Index (DXY). The increase in the U.S. Dollar provided a drag on the performance of both foreign stock and bond indices, in our opinion.

In the U.S. bond market, the results were also disappointing. The top performing major debt group we track was intermediate corporate bonds. The Bloomberg Intermediate Corporate Index posted a total return of -1.99% for the 12-month period ended March 31, 2023. The worst-performing U.S. debt group that we track was U.S. aggregate bonds. The Bloomberg U.S. Aggregate Bond Index posted a total return of -4.78%. The yield on the benchmark 10-Year Treasury Note (“T-Note”) fell by 113 basis points in the period to close at 3.47% on March 31, 2023, according to Bloomberg. For comparative purposes, the average yield on the 10-Year T-Note was 2.19% for the 10-year period ended March 31, 2023.

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Fund Performance Overview (Unaudited)

First Trust Nasdaq Bank ETF (FTXO)

The First Trust Nasdaq Bank ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Banks^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXO.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the banking sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: net income, return on assets, momentum and book value. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TM Index that have been classified as comprising the banking sector according to the Industry Classification Benchmark. The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes companies providing a broad range of financial services, including retail banking, loans and money transmissions.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	-30.94%	-3.62%	3.43%	-16.85%	24.58%
Market Price	-31.05%	-3.66%	3.41%	-17.01%	24.46%
Index Performance
Nasdaq US Smart Banks^TM Index	-30.60%	-3.01%	4.10%	-14.18%	29.98%
Nasdaq US Benchmark Banks Index	-22.33%	0.08%	6.72%	0.42%	52.85%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a net asset value (“NAV”) return of -30.94% during the period covered by this report. During the same period, the Nasdaq US Benchmark Banks Index (the “Benchmark”) generated a return of -22.33%. The Banks industry carried the majority of the weight in the Fund as well as in the Benchmark. This industry had a weight of 90.9% in the Fund during the period covered by this report. The Banks Industry contributed -27.3% to the Fund’s total return, which was the most negative of any industry. No industry contributed positively to the Fund’s total return.

Nasdaq^® and Nasdaq US Smart Banks^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Bank ETF (FTXO) (Continued)

Sector Allocation	% of Total Investments
Financials	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Citigroup, Inc.	9.3%
JPMorgan Chase & Co.	9.1
Bank of America Corp.	8.3
Wells Fargo & Co.	8.0
Truist Financial Corp.	7.3
PNC Financial Services Group (The), Inc.	4.0
M&T Bank Corp.	3.9
US Bancorp	3.8
Fifth Third Bancorp	3.7
Citizens Financial Group, Inc.	3.6
Total	61.0%

Performance figures assume reinvestment of all distributions and do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. An index is a statistical composite that tracks a specified financial market or sector. Unlike the Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by the Fund. These expenses negatively impact the performance of the Fund. The Fund’s past performance does not predict future performance.

Frequency Distribution of Discounts and Premiums

Information showing the number of days the market price of the Fund’s shares was greater (at a premium) and less (at a discount) than the Fund’s net asset value for the most recently completed year, and the most recently completed calendar quarters since that year (or life of the Fund, if shorter), is available at https://www.ftportfolios.com/Retail/etf/home.aspx.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Food & Beverage ETF (FTXG)

The First Trust Nasdaq Food & Beverage ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Food & Beverage^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXG.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the food and beverage sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: gross income, return on assets, momentum and cash flow. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TM Index that have been classified as comprising either the beverages sector or food producers sector according to the Industry Classification Benchmark (“ICB”). The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) manufacturers and shippers of cider or malt products; (ii) producers, distillers, vintners, blenders and shippers of wine and spirits; (iii) manufacturers, bottlers and distributors of non-alcoholic beverages; (iv) companies that grow crops or raise livestock, operate fisheries or own non-tobacco plantations; (v) food producers, including meatpacking, snacks, fruits, vegetables, dairy products and frozen seafood; (vi) producers of pet food; and (vii) manufacturers of dietary supplements, vitamins and related items.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	1.10%	8.00%	6.21%	46.92%	48.15%
Market Price	0.87%	7.95%	6.19%	46.58%	48.03%
Index Performance
Nasdaq US Smart Food & Beverage^TM Index	1.70%	8.69%	6.89%	51.70%	54.44%
Nasdaq US Benchmark Food, Beverage and Tobacco Index	5.17%	10.29%	8.54%	63.18%	70.73%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 1.10% during the period covered by this report. During the same period, the Nasdaq US Benchmark Food, Beverage and Tobacco Index (the “Benchmark”) generated a return of 5.17%. During the same period, the Fund was most heavily weighted toward investments in the Food Products GICS sub-industry, which had an average weight of 69.2%. The Beverages sub-industry, however, contributed the most toward the Fund’s return during the period, with a 1.5% contribution. The Personal Care products sub-industry, which had a relatively low weighting of 0.8% during the period, was the only negative contributor to the Fund’s return, generating -0.3%.

Nasdaq^® and Nasdaq US Smart Food & Beverage^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Food & Beverage ETF (FTXG) (Continued)

Sector Allocation	% of Total Investments
Consumer Staples	96.3%
Materials	3.7
Total	100.0%

Top Ten Holdings	% of Total Investments
General Mills, Inc.	8.3%
Mondelez International, Inc., Class A	8.2
PepsiCo, Inc.	8.1
Coca-Cola (The) Co.	8.0
Archer-Daniels-Midland Co.	7.7
Hershey (The) Co.	4.1
J.M. Smucker (The) Co.	4.1
Campbell Soup Co.	4.0
Conagra Brands, Inc.	4.0
Keurig Dr. Pepper, Inc.	3.9
Total	60.4%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Oil & Gas ETF (FTXN)

The First Trust Nasdaq Oil & Gas ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Oil & Gas^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXN.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the oil and gas sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: gross income, return on assets, momentum and cash flow. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TM Index that have been classified as comprising either the oil & gas producers sector or the oil equipment, services & distribution sector according to the Industry Classification Benchmark (“ICB”). The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) companies engaged in the exploration for and drilling, production, refining and supply of oil and gas products; (ii) integrated oil and gas companies engaged in the exploration for, and drilling, production, refining, distribution and retail sales of, oil and gas products; (iii) suppliers of equipment and services to oil fields and offshore platforms, such as drilling, exploration, seismic-information services and platform construction; and (iv) operators of pipelines carrying oil, gas or other forms of fuel.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	4.66%	8.40%	6.89%	49.66%	54.46%
Market Price	4.62%	8.37%	6.88%	49.46%	54.41%
Index Performance
Nasdaq US Smart Oil & Gas^TM Index	5.14%	9.08%	7.57%	54.39%	60.97%
Nasdaq US Benchmark Energy Index	11.05%	8.91%	7.63%	53.25%	61.62%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of 4.66% during the period covered by this report. During the same period, the Nasdaq US Benchmark Energy Index (the “Benchmark”) generated a return of 11.05%. The Oil, Gas & Consumable Fuels industry received a 97.2% allocation in the Fund during the same period and provided the largest contribution to the Fund’s return at 5.4%. No industry had a negative contribution to the Fund’s return during the period.

Nasdaq^® and Nasdaq US Smart Oil & Gas^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Oil & Gas ETF (FTXN) (Continued)

Sector Allocation	% of Total Investments
Energy	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Chevron Corp.	8.0%
Exxon Mobil Corp.	7.9
ConocoPhillips	7.6
Occidental Petroleum Corp.	7.5
Marathon Petroleum Corp.	7.5
Valero Energy Corp.	4.2
Pioneer Natural Resources Co.	4.0
EOG Resources, Inc.	4.0
Cheniere Energy, Inc.	4.0
Phillips 66	3.9
Total	58.6%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

The First Trust Nasdaq Pharmaceuticals ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Pharmaceuticals^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXH.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the pharmaceutical sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: gross income, return on assets, momentum and cash flow. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TMIndex that have been classified as comprising the pharmaceuticals and biotechnology sub-sectors according to the Industry Classification Benchmark. The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes vaccine producers and manufacturers of prescription or over-the-counter drugs.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	-0.61%	5.31%	5.29%	29.50%	40.02%
Market Price	-0.46%	5.29%	5.29%	29.39%	39.96%
Index Performance
Nasdaq US Smart Pharmaceuticals^TM Index	0.07%	5.99%	5.99%	33.79%	46.17%
Nasdaq US Benchmark Pharmaceuticals Index	2.49%	12.74%	11.66%	82.17%	105.42%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -0.61% during the period covered by this report. During the same period, the Nasdaq US Benchmark Pharmaceuticals Index (the “Benchmark”) generated a return of 2.49%. During the same period, the Fund was most heavily weighted toward investments in the Pharmaceuticals and Biotechnology industries, with an average portfolio weight of 51.3% and 43.9%, respectively. The Biotechnology industry was a relative outperformer for the period covered by this report, contributing 4.5% to the Fund’s return, which was the largest contribution. The largest negative contribution to the Fund’s return was from the Pharmaceuticals industry at -4.8%.

Nasdaq^® and Nasdaq US Smart Pharmaceuticals^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Pharmaceuticals ETF (FTXH) (Continued)

Sector Allocation	% of Total Investments
Health Care	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
AbbVie, Inc.	7.4%
Johnson & Johnson	7.2
Pfizer, Inc.	7.2
Bristol-Myers Squibb Co.	7.2
Merck & Co., Inc.	7.2
Moderna, Inc.	4.0
Eli Lilly & Co.	3.9
Vertex Pharmaceuticals, Inc.	3.9
Regeneron Pharmaceuticals, Inc.	3.9
Amgen, Inc.	3.7
Total	55.6%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network E-Commerce ETF (ISHP)

The First Trust S-Network E-Commerce ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the S-Network Global E-Commerce Index^TM(the “Index”). The Fund lists and principally trades its shares on The Nasdaq Stock Market LLC under the symbol “ISHP.” The Fund will normally invest at least 90% of its net assets (plus any borrowings for investment purposes) in the common stocks and depository receipts that comprise the Index.

The Index seeks to provide exposure to companies with securities listed on recognized global securities exchanges that are principally engaged in the global e-commerce industry. According to VettaFi LLC, to be eligible for inclusion in the Index, a security must be issued by a company engaged in at least one of the four following business segments comprising the global e-commerce industry: (1) content navigation; (2) online retail; (3) online marketplace; and (4) e-commerce infrastructure. The Index is owned and is developed, maintained and sponsored by VettaFi LLC.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	-13.57%	5.87%	5.58%	30.01%	42.52%
Market Price	-15.24%	5.42%	5.24%	30.20%	39.58%
Index Performance
S-Network Global E-Commerce Index^TM⁽¹⁾⁽²⁾	-13.91%	N/A	N/A	N/A	N/A
MSCI ACWI Index⁽³⁾	-7.44%	6.94%	9.05%	39.88%	75.97%
Nasdaq US Smart Retail Index	-7.15%	9.91%	8.81%	60.39%	73.49%
Nasdaq US Benchmark Retail Index	-19.16%	9.54%	12.05%	57.71%	110.12%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -13.57% during the period covered by this report. During the same period, the MSCI ACWI Index (the “Benchmark”) generated a return of -7.44%. During the same period, the Fund was most heavily weighted toward investments in the Internet & Direct Marketing Retail industry and the Interactive Media & Services industry, which had an average weight of 24.2% and 21.3%, respectively. Investments in the Interactive Media & Services industry also contributed the most negatively to the Fund’s return, generating -4.0%. The most positive contribution to the Fund’s return came from the Real Estate Management & Development and Air Freight & Logistics industries, with each contributing 0.6% to the Fund’s return, while only being weighted 3.4% and 5.9%, respectively.

⁽¹⁾

On January 26, 2022, the Fund’s underlying index changed from the Nasdaq US Smart Retail Index to the S-Network Global E-Commerce Index^TM. Therefore, performance and historical returns shown for the periods prior to January 26, 2022, are not necessarily indicative of the performance of the Fund, based on its current Index, would have generated.

⁽²⁾	Because the Fund’s new underlying Index had an inception date of April 30, 2021, performance data is not available for all the periods shown in the table for the Index because performance data does not exist for some of the entire periods.

⁽³⁾	The MSCI ACWI Index serves as the Fund’s new primary benchmark index. The Fund’s investment advisor determined that the MSCI ACWI Index provides a more appropriate comparison to Fund returns.

S-Network and S-Network Global E-Commerce Index^TMare service marks of VettaFi LLC and have been licensed for use by First Trust Advisors L.P. The Fund is not issued, sponsored, endorsed, sold or promoted by VettaFi LLC or its affiliates (collectively, “VettaFi”). VettaFi makes no representation or warranty, express or implied, to the purchasers or owners of the Fund or any member of the public regarding the advisability of investing in securities generally or in the Fund particularly or the ability of the Index to track general market performance.

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Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network E-Commerce ETF (ISHP) (Continued)

Sector Allocation	% of Total Investments
Consumer Discretionary	34.9%
Communication Services	26.7
Industrials	15.6
Financials	11.3
Real Estate	5.0
Consumer Staples	4.4
Information Technology	2.1
Total	100.0%

Top Ten Holdings	% of Total Investments
Meta Platforms, Inc., Class A	2.5%
Shopify, Inc., Class A	2.1
MercadoLibre, Inc.	2.1
Airbnb, Inc., Class A	2.1
DoorDash, Inc., Class A	2.0
Copart, Inc.	2.0
FedEx Corp.	2.0
Booking Holdings, Inc.	1.9
Snap, Inc., Class A	1.9
REA Group Ltd.	1.9
Total	20.5%

Frequency Distribution of Discounts and Premiums

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Semiconductor ETF (FTXL)

The First Trust Nasdaq Semiconductor ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Semiconductor^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXL.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the semiconductor sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: gross income, return on assets, momentum and cash flow. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TM Index that have been classified as comprising the semiconductors sub-sector according to the Industry Classification Benchmark. The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. This classification includes producers and distributors of semiconductors and other integrated chips, including other products related to the semiconductor industry, such as semiconductor capital equipment and motherboards.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	-6.54%	15.55%	20.59%	106.03%	239.28%
Market Price	-6.68%	15.55%	20.58%	106.00%	239.23%
Index Performance
Nasdaq US Smart Semiconductor^TM Index	-6.01%	16.28%	21.36%	112.55%	253.71%
Nasdaq US Benchmark Semiconductors Index	-4.38%	19.00%	22.80%	138.60%	282.11%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -6.54% during the period covered by this report. During the same period, the Nasdaq US Benchmark Semiconductors Index (the “Benchmark”) generated a return of -4.38%. During the same period, the Fund was most heavily weighted toward investments in the Semiconductors industry as expected, with 79.9% weighted towards the Semiconductors sub-industry, and 14.5% toward the Semiconductor Materials and Equipment sub-industry. The largest negative contributions to the Fund’s return were the investments in the Semiconductors and Electronic Components sub-industries, which contributed -3.2% and -2.6% to the Fund’s return, respectively. The largest positive contribution to the Fund’s return was from the Electronic Manufacturing Services sub-industry at 0.7%.

Nasdaq^® and Nasdaq US Smart Semiconductor^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

Page 14

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Semiconductor ETF (FTXL) (Continued)

Sector Allocation	% of Total Investments
Information Technology	100.0%
Total	100.0%

Top Ten Holdings	% of Total Investments
Intel Corp.	9.6%
Texas Instruments, Inc.	8.0
Broadcom, Inc.	7.9
Micron Technology, Inc.	7.7
QUALCOMM, Inc.	7.6
NVIDIA Corp.	4.4
Lam Research Corp.	4.0
Analog Devices, Inc.	3.9
ON Semiconductor Corp.	3.9
Applied Materials, Inc.	3.9
Total	60.9%

Frequency Distribution of Discounts and Premiums

Page 15

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Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Transportation ETF (FTXR)

The First Trust Nasdaq Transportation ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an equity index called the Nasdaq US Smart Transportation^TM Index (the “Index”). The shares of the Fund are listed and trade on The Nasdaq Stock Market LLC under the ticker symbol “FTXR.” The Fund will normally invest at least 90% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Index is owned and is developed, maintained and sponsored by Nasdaq, Inc. (the “Index Provider”).

The Index is designed to provide exposure to U.S. companies comprising the transportation sector that have been selected based upon their liquidity and weighted based upon their cumulative score on four investing factors: gross income, return on assets, momentum and cash flow. The Index’s initial selection universe consists of the component securities of the Nasdaq US Benchmark^TM Index that have been classified as comprising the industrial transportation sector, the automobiles & parts sector or the airlines sub-sector according to the Industry Classification Benchmark. The Nasdaq US Benchmark^TM Index is an index seeking to track the performance of small, mid and large capitalization U.S. companies. These classifications include: (i) operators of mail and package delivery services; (ii) providers of on-water transportation for commercial markets; (iii) providers of industrial railway transportation and railway lines; (iv) companies that manage airports, train depots, roads, bridges, tunnels, ports, and providers of logistic services to shippers of goods; (v) companies that provide commercial trucking services; (vi) makers of motorcycles and passenger vehicles; (vii) manufacturers and distributors of new and replacement parts for motorcycles and automobiles; (viii) manufacturers, distributors and retreaders of automobile, truck and motorcycle tires; and (ix) companies providing primarily passenger air transport.

Performance
		Average Annual Total Returns		Cumulative Total Returns
	1 Year Ended 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23	5 Years Ended 3/31/23	Inception (9/20/16) to 3/31/23
Fund Performance
NAV	-13.76%	3.11%	6.26%	16.55%	48.60%
Market Price	-13.78%	3.08%	6.26%	16.37%	48.59%
Index Performance
Nasdaq US Smart Transportation^TM Index	-13.63%	3.50%	6.73%	18.75%	53.00%
Nasdaq US Benchmark Industrial Transportation Index	-9.67%	11.77%	14.50%	74.43%	142.02%
Nasdaq US Benchmark^TM Index	-8.97%	10.44%	12.01%	64.29%	109.61%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -13.76% during the period covered by this report. During the same period, the Nasdaq US Benchmark Industrial Transportation Index (the “Benchmark”) generated a return of -9.67%. The Ground Transportation industry’s 28.9% allocation was the largest weight in the Fund during the period. This industry also had the greatest negative contribution to the Fund’s return, generating -6.8% during the period. The greatest contribution to the Fund’s return was the 1.0% from the Distributors industry.

Nasdaq^® and Nasdaq US Smart Transportation^TM Index are registered trademarks and service marks of Nasdaq, Inc. (together with its affiliates hereinafter referred to as the “Corporations”) and are licensed for use by First Trust. The Fund has not been passed on by the Corporations as to its legality or suitability. The Fund is not issued, endorsed, sold or promoted by the Corporations. THE CORPORATIONS MAKE NO WARRANTIES AND BEAR NO LIABILITY WITH RESPECT TO THE FUND.

Page 16

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust Nasdaq Transportation ETF (FTXR) (Continued)

Sector Allocation	% of Total Investments
Industrials	74.7%
Consumer Discretionary	25.3
Total	100.0%

Top Ten Holdings	% of Total Investments
FedEx Corp.	9.1%
United Parcel Service, Inc., Class B	8.6
Tesla, Inc.	8.1
Union Pacific Corp.	7.8
General Motors Co.	7.6
PACCAR, Inc.	4.0
CSX Corp.	4.0
Norfolk Southern Corp.	3.8
Delta Air Lines, Inc.	3.7
United Airlines Holdings, Inc.	3.4
Total	60.1%

Frequency Distribution of Discounts and Premiums

Page 17

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network Streaming & Gaming ETF (BNGE)

The First Trust S-Network Streaming & Gaming ETF (the “Fund”) seeks investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of an index called the S-Network Streaming & Gaming Index (the “Index”). The Fund lists and principally trades its shares on The NYSE Arca, Inc. under the ticker symbol “BNGE.” The Fund will normally invest at least 80% of its net assets (including investment borrowings) in the common stocks and depositary receipts that comprise the Index. The Fund, using an indexing investment approach, attempts to replicate, before fees and expenses, the performance of the Index.

According to VettaFi LLC (the “Index Provider”), the Index is composed of common stock and depositary receipts issued by U.S. and non-U.S. companies that enable remote users to access online content; publish online content; participate in prospective wagering; spectate or participate in competitive video gaming; and that provide the products, services and technology that are necessary for the streaming and gaming industries. The Index is owned and is developed, maintained and sponsored by VettaFi LLC. The Index Provider retains the right at any time, upon prior written notice, to modify the Index methodology.

Performance
		Average Annual Total Returns	Cumulative Total Returns
	1 Year Ended 3/31/23	Inception (1/25/22) to 3/31/23	Inception (1/25/22) to 3/31/23
Fund Performance
NAV	-9.08%	-11.55%	-13.46%
Market Price	-9.37%	-11.37%	-13.25%
Index Performance
S-Network Streaming & Gaming Index	-8.64%	-10.64%	-12.41%
MSCI ACWI Index	-7.44%	-4.78%	-5.60%

(See Notes to Fund Performance Overview on page 20.)

Performance Review

The Fund generated a NAV return of -9.08% during the period covered by this report. During the same period, the MSCI ACWI Index (the “Benchmark”) generated a return of -7.44%. The United States was the highest weighted country in the Fund during the period with an allocation of 53.0%. Investments in this country contributed -7.9% to the Fund’s return, which was the greatest drag on the Fund’s return of any country in the Fund. The greatest positive contribution to the Fund’s return came from investments in Ireland with a contribution of 2.2%. Exposure to foreign currency contributed -1.7% to the Fund’s total return for the period.

S-Network and S-Network Streaming & Gaming Indexare service marks of VettaFi LLC and have been licensed for use by First Trust Advisors L.P. The Fund is not issued, sponsored, endorsed, sold or promoted by VettaFi LLC or its affiliates (collectively, “VettaFi”). VettaFi makes no representation or warranty, express or implied, to the purchasers or owners of the Fund or any member of the public regarding the advisability of investing in securities generally or in the Fund particularly or the ability of the Index to track general market performance.

Page 18

Table of Contents

Fund Performance Overview (Unaudited) (Continued)

First Trust S-Network Streaming & Gaming ETF (BNGE) (Continued)

Portfolio Sector Allocation	% of Total Long-Term Investments
Communication Services	57.2%
Consumer Discretionary	24.1
Information Technology	18.7
Total	100.0%

Top Ten Holdings	% of Total Long-Term Investments
NVIDIA Corp.	6.9%
Advanced Micro Devices, Inc.	5.7
Warner Bros Discovery, Inc.	4.7
Flutter Entertainment PLC	4.7
Activision Blizzard, Inc.	4.6
Intel Corp.	4.4
Sony Group Corp.	4.4
Netflix, Inc.	4.3
Tencent Holdings Ltd.	4.3
NetEase, Inc., ADR	4.3
Total	48.3%

Frequency Distribution of Discounts and Premiums

Page 19

Table of Contents

Notes to Fund Performance Overview (Unaudited)

Total returns for the periods since inception are calculated from the inception date of each Fund. “Average Annual Total Returns” represent the average annual change in value of an investment over the periods indicated. “Cumulative Total Returns” represent the total change in value of an investment over the periods indicated.

Each Fund’s per share net asset value (“NAV”) is the value of one share of the Fund and is computed by dividing the value of all assets of the Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of outstanding shares. The price used to calculate market return (“Market Price”) is determined by using the midpoint of the national best bid and offer price (“NBBO”) as of the time that the Fund’s NAV is calculated. Under SEC rules, the NBBO consists of the highest displayed buy and lowest sell prices among the various exchanges trading the Fund at the time the Fund’s NAV is calculated. Prior to January 1, 2019, the price used was the midpoint between the highest bid and the lowest offer on the stock exchange on which shares of the Fund were listed for trading as of the time that the Fund’s NAV was calculated. Since shares of each Fund did not trade in the secondary market until after the Fund’s inception, for the period from inception to the first day of secondary market trading in shares of the Fund, the NAV of each Fund is used as a proxy for the secondary market trading price to calculate market returns. NAV and market returns assume that all distributions have been reinvested in each Fund at NAV and Market Price, respectively.

An index is a statistical composite that tracks a specified financial market or sector. Unlike each Fund, the indices do not actually hold a portfolio of securities and therefore do not incur the expenses incurred by each Fund. These expenses negatively impact the performance of each Fund. Also, market returns do not include brokerage commissions that may be payable on secondary market transactions. If brokerage commissions were included, market returns would be lower. The total returns presented reflect the reinvestment of dividends on securities in the indices. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. The investment return and principal value of shares of each Fund will vary with changes in market conditions. Shares of each Fund may be worth more or less than their original cost when they are redeemed or sold in the market. Each Fund’s past performance is no guarantee of future performance.

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First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses

March 31, 2023 (Unaudited)

As a shareholder of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust S-Network E-Commerce ETF, First Trust Nasdaq Semiconductor ETF, First Trust Nasdaq Transportation ETF or First Trust S-Network Streaming & Gaming ETF (each a “Fund” and collectively, the “Funds”), you incur two types of costs: (1) transaction costs; and (2) ongoing costs, including management fees, distribution and/or service (12b-1) fees, if any, and other Fund expenses. This Example is intended to help you understand your ongoing costs of investing in the Funds and to compare these costs with the ongoing costs of investing in other funds.

The Example is based on an investment of $1,000 invested at the beginning of the period and held through the six-month period ended March 31, 2023.

Actual Expenses

The first line in the following table provides information about actual account values and actual expenses. You may use the information in this line, together with the amount you invested, to estimate the expenses that you paid over the period. Simply divide your account value by $1,000 (for example, an $8,600 account value divided by $1,000 = 8.6), then multiply the result by the number in the first line under the heading entitled “Expenses Paid During the Six-Month Period” to estimate the expenses you paid on your account during this six-month period.

Hypothetical Example for Comparison Purposes

The second line in the following table provides information about hypothetical account values and hypothetical expenses based on each Fund’s actual expense ratio and an assumed rate of return of 5% per year before expenses, which is not each Fund’s actual return. The hypothetical account values and expenses may not be used to estimate the actual ending account balance or expenses you paid for the period. You may use this information to compare the ongoing costs of investing in the Funds and other funds. To do so, compare this 5% hypothetical example with the 5% hypothetical examples that appear in the shareholder reports of the other funds.

Please note that the expenses shown in the table are meant to highlight your ongoing costs only and do not reflect any transactional costs such as brokerage commissions. Therefore, the second line in the table is useful in comparing ongoing costs only, and will not help you determine the relative total costs of owning different funds. In addition, if these transactional costs were included, your costs would have been higher.

	Beginning Account Value October 1, 2022	Ending Account Value March 31, 2023	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
First Trust Nasdaq Bank ETF (FTXO)
Actual	$1,000.00	$833.60	0.60%	$2.74
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Food & Beverage ETF (FTXG)
Actual	$1,000.00	$1,096.00	0.60%	$3.14
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Oil & Gas ETF (FTXN)
Actual	$1,000.00	$1,114.90	0.60%	$3.16
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Pharmaceuticals ETF (FTXH)
Actual	$1,000.00	$1,096.20	0.60%	$3.14
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust S-Network E-Commerce ETF (ISHP)
Actual	$1,000.00	$1,238.60	0.60%	$3.35
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust Nasdaq Semiconductor ETF (FTXL)
Actual	$1,000.00	$1,339.10	0.60%	$3.50
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02

Page 21

Table of Contents

First Trust Exchange-Traded Fund VI

Understanding Your Fund Expenses (Continued)

March 31, 2023 (Unaudited)

	Beginning Account Value October 1, 2022	Ending Account Value March 31, 2023	Annualized Expense Ratio Based on the Six-Month Period	Expenses Paid During the Six-Month Period (a)
First Trust Nasdaq Transportation ETF (FTXR)
Actual	$1,000.00	$1,178.80	0.60%	$3.26
Hypothetical (5% return before expenses)	$1,000.00	$1,021.94	0.60%	$3.02
First Trust S-Network Streaming & Gaming ETF (BNGE)
Actual	$1,000.00	$1,322.20	0.70%	$4.05
Hypothetical (5% return before expenses)	$1,000.00	$1,021.44	0.70%	$3.53

(a)	Expenses are equal to the annualized expense ratios as indicated in the table multiplied by the average account value over the period (October 1, 2022 through March 31, 2023), multiplied by 182/365 (to reflect the six-month period).

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Table of Contents

First Trust Nasdaq Bank ETF (FTXO)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.7%
	Banks – 96.7%
27,479	Ameris Bancorp	$1,005,182
67,909	Associated Banc-Corp.	1,221,004
27,558	Atlantic Union Bankshares Corp.	965,908
11,438	BancFirst Corp.	950,498
479,179	Bank of America Corp.	13,704,519
38,883	Bank OZK	1,329,799
18,402	BOK Financial Corp.	1,553,313
24,053	Cathay General Bancorp	830,310
324,241	Citigroup, Inc.	15,203,660
196,787	Citizens Financial Group, Inc.	5,976,421
28,094	Comerica, Inc.	1,219,841
15,605	Commerce Bancshares, Inc.	910,552
9,338	Cullen/Frost Bankers, Inc.	983,665
32,307	East West Bancorp, Inc.	1,793,038
226,387	Fifth Third Bancorp	6,030,950
4,922	First Citizens BancShares, Inc., Class A	4,789,598
37,744	First Hawaiian, Inc.	778,659
159,885	FNB Corp.	1,854,666
61,703	Fulton Financial Corp.	852,735
27,994	Hancock Whitney Corp.	1,018,982
60,197	Home BancShares, Inc.	1,306,877
417,944	Huntington Bancshares, Inc.	4,680,973
14,905	Independent Bank Corp.	978,066
21,273	International Bancshares Corp.	910,910
114,654	JPMorgan Chase & Co.	14,940,563
246,383	KeyCorp	3,084,715
52,921	M&T Bank Corp.	6,327,764
114,036	Old National Bancorp	1,644,399
35,510	Pacific Premier Bancorp, Inc.	852,950
29,441	Pinnacle Financial Partners, Inc.	1,623,966
52,038	PNC Financial Services Group (The), Inc.	6,614,030
23,459	Popular, Inc.	1,346,781
37,502	Prosperity Bancshares, Inc.	2,307,123
252,057	Regions Financial Corp.	4,678,178
25,877	SouthState Corp.	1,843,995
38,755	Synovus Financial Corp.	1,194,817
17,116	Texas Capital Bancshares, Inc. (a)	837,999
350,069	Truist Financial Corp.	11,937,353
12,103	UMB Financial Corp.	698,585
45,571	United Bankshares, Inc.	1,604,099
172,174	US Bancorp	6,206,873
219,945	Valley National Bancorp	2,032,292
57,993	Webster Financial Corp.	2,286,084
351,418	Wells Fargo & Co.	13,136,005
28,045	Western Alliance Bancorp	996,719
19,578	Wintrust Financial Corp.	1,428,215
20,686	WSFS Financial Corp.	778,000
		159,251,631

Shares	Description	Value

	Consumer Finance – 3.0%
49,711	Discover Financial Services	$4,913,435
	Total Investments – 99.7%	164,165,066
	(Cost $194,286,325)
	Net Other Assets and Liabilities – 0.3%	542,958
	Net Assets – 100.0%	$164,708,024

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 164,165,066	$ 164,165,066	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 23

Table of Contents

First Trust Nasdaq Food & Beverage ETF (FTXG)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.9%
	Beverages – 27.4%
581,855	Brown-Forman Corp., Class B	$37,395,821
1,268,544	Coca-Cola (The) Co.	78,687,785
46,148	Coca-Cola Consolidated, Inc.	24,692,872
1,092,492	Keurig Dr. Pepper, Inc.	38,543,118
94,309	Monster Beverage Corp. (a)	5,093,629
120,442	National Beverage Corp. (a)	6,349,702
435,031	PepsiCo, Inc.	79,306,151
		270,069,078
	Chemicals – 3.7%
605,952	Corteva, Inc.	36,544,965
	Consumer Staples Distribution & Retail – 3.4%
897,496	US Foods Holding Corp. (a)	33,153,502
	Food Products – 64.9%
948,389	Archer-Daniels-Midland Co.	75,548,668
50,255	Bunge Ltd.	4,800,358
718,685	Campbell Soup Co.	39,513,301
1,036,674	Conagra Brands, Inc.	38,937,475
566,314	Flowers Foods, Inc.	15,522,667
949,426	General Mills, Inc.	81,137,946
158,356	Hershey (The) Co.	40,287,350
850,525	Hormel Foods Corp.	33,918,937
450,342	Hostess Brands, Inc. (a)	11,204,509
58,252	Ingredion, Inc.	5,925,976
255,231	J.M. Smucker (The) Co.	40,165,702
572,418	Kellogg Co.	38,329,109
969,309	Kraft Heinz (The) Co.	37,483,179
218,511	Lamb Weston Holdings, Inc.	22,838,770
46,449	Lancaster Colony Corp.	9,423,573
1,158,200	Mondelez International, Inc., Class A	80,749,704
159,886	Post Holdings, Inc. (a)	14,368,955
138,491	Simply Good Foods (The), Co. (a)	5,507,787
98,371	TreeHouse Foods, Inc. (a)	4,960,849
637,130	Tyson Foods, Inc., Class A	37,794,552
		638,419,367
	Personal Care Products – 0.5%
155,442	BellRing Brands, Inc. (a)	5,285,028
	Total Investments – 99.9%	983,471,940
	(Cost $968,528,695)
	Net Other Assets and Liabilities – 0.1%	867,494
	Net Assets – 100.0%	$984,339,434

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 983,471,940	$ 983,471,940	$ —	$ —

*	See Portfolio of Investments for industry breakout.

Page 24

See Notes to Financial Statements

Table of Contents

First Trust Nasdaq Oil & Gas ETF (FTXN)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.8%
	Energy Equipment & Services – 4.4%
80,592	Baker Hughes Co.	$2,325,885
51,811	ChampionX Corp.	1,405,632
90,159	Halliburton Co.	2,852,631
104,186	Liberty Energy, Inc.	1,334,622
94,478	Schlumberger N.V.	4,638,870
23,911	Weatherford International PLC (a)	1,419,118
		13,976,758
	Oil, Gas & Consumable Fuels – 95.4%
187,817	APA Corp.	6,772,681
78,910	Cheniere Energy, Inc.	12,436,216
73,962	Chesapeake Energy Corp.	5,624,070
154,686	Chevron Corp.	25,238,568
20,409	Chord Energy Corp.	2,747,051
50,789	Civitas Resources, Inc.	3,470,920
203,317	Comstock Resources, Inc.	2,193,790
240,410	ConocoPhillips	23,851,076
314,173	Coterra Energy, Inc.	7,709,805
49,830	CVR Energy, Inc.	1,633,427
18,914	Denbury, Inc. (a)	1,657,434
229,251	Devon Energy Corp.	11,602,393
64,932	Diamondback Energy, Inc.	8,776,858
109,828	EOG Resources, Inc.	12,589,584
152,278	EQT Corp.	4,859,191
226,214	Exxon Mobil Corp.	24,806,627
42,708	Hess Corp.	5,651,977
110,336	HF Sinclair Corp.	5,338,056
202,768	Kosmos Energy Ltd. (a)	1,508,594
85,723	Magnolia Oil & Gas Corp., Class A	1,875,619
311,153	Marathon Oil Corp.	7,455,226
174,490	Marathon Petroleum Corp.	23,526,487
53,647	Matador Resources, Co.	2,556,280
78,664	Murphy Oil Corp.	2,908,995
378,479	Occidental Petroleum Corp.	23,628,444
65,009	ONEOK, Inc.	4,130,672
120,421	Ovintiv, Inc.	4,344,790
160,105	PBF Energy, Inc., Class A	6,942,153
59,910	PDC Energy, Inc.	3,845,024
172,513	Permian Resources Corp.	1,811,387
121,116	Phillips 66	12,278,740
62,031	Pioneer Natural Resources Co.	12,669,211
58,810	Range Resources Corp.	1,556,701
846,191	Southwestern Energy Co. (a)	4,230,955
45,996	Targa Resources Corp.	3,355,408
786	Texas Pacific Land Corp.	1,337,002

Shares	Description	Value

	Oil, Gas & Consumable Fuels (Continued)
94,222	Valero Energy Corp.	$13,153,391
		300,074,803
	Total Investments – 99.8%	314,051,561
	(Cost $309,207,818)
	Net Other Assets and Liabilities – 0.2%	544,677
	Net Assets – 100.0%	$314,596,238

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 314,051,561	$ 314,051,561	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 25

Table of Contents

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.9%
	Biotechnology – 44.2%
15,163	AbbVie, Inc.	$2,416,527
7,838	ACADIA Pharmaceuticals, Inc. (a)	147,511
6,065	Alkermes PLC (a)	170,972
847	Alnylam Pharmaceuticals, Inc. (a)	169,671
5,036	Amgen, Inc.	1,217,453
12,296	Amicus Therapeutics, Inc. (a)	136,363
3,862	Biogen, Inc. (a)	1,073,752
1,629	BioMarin Pharmaceutical, Inc. (a)	158,404
2,602	Exact Sciences Corp. (a)	176,442
15,179	Exelixis, Inc. (a)	294,624
14,489	Gilead Sciences, Inc.	1,202,152
4,657	Halozyme Therapeutics, Inc. (a)	177,851
9,690	Incyte Corp. (a)	700,296
4,517	Ionis Pharmaceuticals, Inc. (a)	161,438
7,804	IVERIC bio, Inc. (a)	189,871
813	Karuna Therapeutics, Inc. (a)	147,673
8,405	Moderna, Inc. (a)	1,290,840
1,875	Neurocrine Biosciences, Inc. (a)	189,788
1,325	Prometheus Biosciences, Inc. (a)	142,199
2,909	Prothena Corp. PLC (a)	140,999
3,713	PTC Therapeutics, Inc. (a)	179,858
1,535	Regeneron Pharmaceuticals, Inc. (a)	1,261,263
20,046	Roivant Sciences Ltd. (a)	147,940
1,328	Sarepta Therapeutics, Inc. (a)	183,038
903	Seagen, Inc. (a)	182,830
2,685	United Therapeutics Corp. (a)	601,333
3,958	Vaxcyte, Inc. (a)	148,346
4,019	Vertex Pharmaceuticals, Inc. (a)	1,266,266
7,113	Vir Biotechnology, Inc. (a)	165,520
		14,441,220
	Health Care Equipment & Supplies – 0.4%
2,107	Novocure Ltd. (a)	126,715
	Health Care Providers & Services – 3.6%
15,411	Cardinal Health, Inc.	1,163,530
	Life Sciences Tools & Services – 3.5%
2,421	Charles River Laboratories International, Inc. (a)	488,606
1,846	Medpace Holdings, Inc. (a)	347,141
8,600	Syneos Health, Inc. (a)	306,332
		1,142,079
	Pharmaceuticals – 48.2%
2,379	Axsome Therapeutics, Inc. (a)	146,737
33,840	Bristol-Myers Squibb Co.	2,345,450
4,113	Catalent, Inc. (a)	270,265
14,139	Elanco Animal Health, Inc. (a)	132,907

Shares	Description	Value

	Pharmaceuticals (Continued)
3,749	Eli Lilly & Co.	$1,287,482
3,683	Harmony Biosciences Holdings, Inc. (a)	120,250
7,241	Jazz Pharmaceuticals PLC (a)	1,059,576
15,226	Johnson & Johnson	2,360,030
21,965	Merck & Co., Inc.	2,336,856
30,293	Organon & Co.	712,491
6,587	Perrigo Co. PLC	236,276
57,519	Pfizer, Inc.	2,346,775
3,548	Prestige Consumer Healthcare, Inc. (a)	222,211
102,348	Viatris, Inc.	984,588
6,987	Zoetis, Inc.	1,162,916
		15,724,810
	Total Investments – 99.9%	32,598,354
	(Cost $32,505,824)
	Net Other Assets and Liabilities – 0.1%	41,349
	Net Assets – 100.0%	$32,639,703

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 32,598,354	$ 32,598,354	$ —	$ —

*	See Portfolio of Investments for industry breakout.

Page 26

See Notes to Financial Statements

Table of Contents

First Trust S-Network E-Commerce ETF (ISHP)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 97.6%
	Air Freight & Logistics – 7.2%
2,111	Deutsche Post AG (a)	$98,870
452	FedEx Corp.	103,278
474	United Parcel Service, Inc., Class B	91,951
3,047	ZTO Express Cayman, Inc., ADR (b)	87,327
		381,426
	Banks – 1.4%
3,901	KakoaBank Corp. (a)	72,910
	Broadline Retail – 15.4%
766	Alibaba Group Holding Ltd., ADR (b)	78,270
909	Amazon.com, Inc. (b)	93,891
5,124	Coupang, Inc. (b)	81,984
1,866	eBay, Inc.	82,794
658	Etsy, Inc. (b)	73,255
1,372	JD.com, Inc., ADR	60,217
85	MercadoLibre, Inc. (b)	112,035
444	Naspers Ltd., Class N (a)	82,271
927	PDD Holdings, Inc., ADR (b)	70,359
1,066	Prosus N.V. (a)	83,472
		818,548
	Commercial Services & Supplies – 1.9%
1,385	Copart, Inc. (b)	104,166
	Consumer Staples Distribution & Retail – 4.3%
92,000	Alibaba Health Information Technology Ltd. (a) (b)	66,352
10,106	JD Health International, Inc. (a) (b) (c) (d)	74,936
598	Walmart, Inc.	88,175
		229,463
	Financial Services – 9.8%
61	Adyen N.V. (a) (b) (c) (d)	97,199
1,251	Fidelity National Information Services, Inc.	67,967
846	Fiserv, Inc. (b)	95,623
445	FleetCor Technologies, Inc. (b)	93,828
800	Global Payments, Inc.	84,192
1,086	PayPal Holdings, Inc. (b)	82,471
		521,280
	Ground Transportation – 1.8%
2,984	Uber Technologies, Inc. (b)	94,593
	Hotels, Restaurants & Leisure – 11.5%
880	Airbnb, Inc., Class A (b)	109,472
38	Booking Holdings, Inc. (b)	100,792
1,604	Delivery Hero SE (a) (b) (c) (d)	54,720

Shares	Description	Value

	Hotels, Restaurants & Leisure (Continued)
1,665	DoorDash, Inc., Class A (b)	$105,827
841	Expedia Group, Inc. (b)	81,602
3,907	Meituan, Class B (a) (b) (c) (d)	70,882
2,343	Trip.com Group Ltd., ADR (b)	88,261
		611,556
	Interactive Media & Services – 24.8%
951	Alphabet, Inc., Class A (b)	98,647
12,901	Auto Trader Group PLC (a) (c) (d)	98,405
635	Baidu, Inc., ADR (b)	95,834
5,715	carsales.com Ltd. (a)	85,411
9,200	Kuaishou Technology (a) (b) (c) (d)	70,742
634	Meta Platforms, Inc., Class A (b)	134,370
555	NAVER Corp. (a)	86,963
3,277	Pinterest, Inc., Class A (b)	89,364
1,078	REA Group Ltd. (a)	100,516
13,062	Rightmove PLC (a)	90,920
5,600	SEEK Ltd. (a)	90,525
8,987	Snap, Inc., Class A (b)	100,744
4,328	Weibo Corp., ADR (b)	86,820
6,796	Yandex N.V., Class A (a) (b) (e) (f)	0
32,800	Z Holdings Corp. (a)	93,003
		1,322,264
	IT Services – 2.1%
2,357	Shopify, Inc., Class A (b)	112,995
	Marine Transportation – 3.2%
41	AP Moller - Maersk A.S., Class B (a)	74,526
84,500	COSCO SHIPPING Holdings Co., Ltd., Class H (a)	95,263
		169,789
	Professional Services – 1.4%
1,079	CoStar Group, Inc. (b)	74,289
	Real Estate Management & Development – 3.3%
4,601	KE Holdings, Inc., ADR (b)	86,683
2,004	Zillow Group, Inc., Class C (b)	89,118
		175,801
	Specialty Retail – 5.9%
1,003	Best Buy Co., Inc.	78,505
1,295	CarMax, Inc. (b)	83,243
1,980	Chewy, Inc., Class A (b)	74,012
1,914	Zalando SE (a) (b) (c) (d)	80,217
		315,977

See Notes to Financial Statements

Page 27

Table of Contents

First Trust S-Network E-Commerce ETF (ISHP)

Portfolio of Investments (Continued)

March 31, 2023

Shares	Description	Value
COMMON STOCKS (Continued)
	Textiles, Apparel & Luxury Goods – 1.9%
275	Lululemon Athletica, Inc. (b)	$100,152
	Wireless Telecommunication Services – 1.7%
27,243	Taiwan Mobile Co., Ltd. (a)	90,394
	Total Common Stocks	5,195,603
	(Cost $6,137,705)
REAL ESTATE INVESTMENT TRUSTS – 1.6%
	Industrial REITs – 1.6%
709	Prologis, Inc.	88,462
	(Cost $108,155)
	Total Investments – 99.2%	5,284,065
	(Cost $6,245,860)
	Net Other Assets and Liabilities – 0.8%	40,163
	Net Assets – 100.0%	$5,324,228

(a)	This security is fair valued by the Advisor’s Pricing Committee in accordance with procedures approved by the Trust’s Board of Trustees and in accordance with provisions of the Investment Company Act of 1940 and rules thereunder, as amended. At March 31, 2023, securities noted as such are valued at $1,758,497 or 33.0% of net assets. Certain of these securities are fair valued using a factor provided by a third-party pricing service due to the change in value between the foreign markets’ close and the New York Stock Exchange close exceeding a certain threshold. On days when this threshold is not exceeded, these securities are typically valued at the last sale price on the exchange on which they are principally traded.
(b)	Non-income producing security.
(c)	This security may be resold to qualified foreign investors and foreign institutional buyers under Regulation S of the Securities Act of 1933, as amended (the “1933 Act”).
(d)	This security is exempt from registration upon resale under Rule 144A of the 1933 Act and may be resold in transactions exempt from registration, normally to qualified institutional buyers. This security is not restricted on the foreign exchange where it trades freely without any additional registration. As such, it does not require the additional disclosure required of restricted securities.
(e)	Pursuant to procedures adopted by the Trust’s Board of Trustees, this security has been determined to be illiquid by the Advisor.
(f)	This security’s value was determined using significant unobservable inputs (see Note 2A – Portfolio Valuation in the Notes to Financial Statements).

ADR	American Depositary Receipt

Currency Exposure Diversification	% of Total Investments
United States Dollar	66.7%
Euro	7.8
Hong Kong Dollar	7.2
Australian Dollar	5.2
British Pound Sterling	3.6
South Korean Won	3.0
Japanese Yen	1.8
New Taiwan Dollar	1.7
South African Rand	1.6
Danish Krone	1.4
Total	100.0%

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks:
Air Freight & Logistics	$ 381,426	$ 282,556	$ 98,870	$ —
Banks	72,910	—	72,910	—
Broadline Retail	818,548	652,805	165,743	—
Consumer Staples Distribution & Retail	229,463	88,175	141,288	—
Financial Services	521,280	424,081	97,199	—
Hotels, Restaurants & Leisure	611,556	485,954	125,602	—
Interactive Media & Services	1,322,264	605,779	716,485	—**
Marine Transportation	169,789	—	169,789	—
Specialty Retail	315,977	235,760	80,217	—
Wireless Telecommunication Services	90,394	—	90,394	—
Other Industry Categories*	661,996	661,996	—	—
Real Estate Investment Trusts*	88,462	88,462	—	—
Total Investments	$ 5,284,065	$ 3,525,568	$ 1,758,497	$—**

*	See Portfolio of Investments for industry breakout.
**	Investment is valued at $0.

Level 3 investments are fair valued by the Advisor’s Pricing Committee and are footnoted in the Portfolio of Investments. The Level 3 investments values are based on unobservable and non-quantitative inputs.

Page 28

See Notes to Financial Statements

Table of Contents

First Trust Nasdaq Semiconductor ETF (FTXL)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.8%
	Electronic Equipment, Instruments & Components – 4.2%
77,179	Advanced Energy Industries, Inc.	$7,563,542
102,171	Avnet, Inc.	4,618,129
63,145	IPG Photonics Corp. (a)	7,786,410
961,048	Vishay Intertechnology, Inc.	21,738,906
		41,706,987
	Semiconductors & Semiconductor Equipment – 95.6%
128,417	Allegro MicroSystems, Inc. (a)	6,162,732
1,405,440	Amkor Technology, Inc.	36,569,549
197,334	Analog Devices, Inc.	38,918,212
311,709	Applied Materials, Inc.	38,287,216
65,891	Axcelis Technologies, Inc. (a)	8,779,976
121,715	Broadcom, Inc.	78,085,041
203,132	Cirrus Logic, Inc. (a)	22,218,578
169,878	Diodes, Inc. (a)	15,757,883
2,904,509	Intel Corp.	94,890,309
95,460	KLA Corp.	38,104,768
74,430	Lam Research Corp.	39,456,832
101,251	Lattice Semiconductor Corp. (a)	9,669,471
91,786	MACOM Technology Solutions Holdings, Inc. (a)	6,502,120
446,822	Microchip Technology, Inc.	37,434,747
1,252,327	Micron Technology, Inc.	75,565,411
14,012	Monolithic Power Systems, Inc.	7,013,566
155,867	NVIDIA Corp.	43,295,177
202,828	NXP Semiconductors N.V.	37,822,351
467,582	ON Semiconductor Corp. (a)	38,491,350
60,709	Onto Innovation, Inc. (a)	5,335,107
102,492	Power Integrations, Inc.	8,674,923
358,967	Qorvo, Inc. (a)	36,460,278
586,203	QUALCOMM, Inc.	74,787,779
25,615	Silicon Laboratories, Inc. (a)	4,484,930
324,517	Skyworks Solutions, Inc.	38,286,516
227,530	Teradyne, Inc.	24,461,750
422,412	Texas Instruments, Inc.	78,572,856
		944,089,428
	Total Investments – 99.8%	985,796,415
	(Cost $945,362,146)
	Net Other Assets and Liabilities – 0.2%	2,299,635
	Net Assets – 100.0%	$988,096,050

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 985,796,415	$ 985,796,415	$ —	$ —

*	See Portfolio of Investments for industry breakout.

See Notes to Financial Statements

Page 29

Table of Contents

First Trust Nasdaq Transportation ETF (FTXR)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS – 99.9%
	Air Freight & Logistics – 23.6%
9,818	CH Robinson Worldwide, Inc.	$975,615
12,287	Expeditors International of Washington, Inc.	1,353,044
18,897	FedEx Corp.	4,317,776
2,361	Forward Air Corp.	254,421
2,998	Hub Group, Inc., Class A (a)	251,652
21,044	United Parcel Service, Inc., Class B	4,082,326
		11,234,834
	Automobile Components – 6.1%
6,317	Aptiv PLC (a)	708,704
19,387	BorgWarner, Inc.	952,096
2,618	Dorman Products, Inc. (a)	225,829
8,530	Gentex Corp.	239,096
4,097	Lear Corp.	571,490
1,457	Visteon Corp. (a)	228,501
		2,925,716
	Automobiles – 15.7%
99,127	General Motors Co.	3,635,978
18,669	Tesla, Inc. (a)	3,873,071
		7,509,049
	Construction & Engineering – 0.9%
8,708	WillScot Mobile Mini Holdings Corp. (a)	408,231
	Distributors – 3.3%
5,041	Genuine Parts Co.	843,410
13,257	LKQ Corp.	752,467
		1,595,877
	Ground Transportation – 27.5%
62,974	CSX Corp.	1,885,442
5,966	JB Hunt Transport Services, Inc.	1,046,794
15,809	Knight-Swift Transportation Holdings, Inc.	894,473
2,112	Landstar System, Inc.	378,597
8,541	Norfolk Southern Corp.	1,810,692
3,075	Old Dominion Freight Line, Inc.	1,048,083
14,395	Ryder System, Inc.	1,284,610
1,085	Saia, Inc. (a)	295,207
18,527	Union Pacific Corp.	3,728,744
5,903	Werner Enterprises, Inc.	268,527
14,292	XPO, Inc. (a)	455,915
		13,097,084
	Machinery – 6.6%
8,369	Allison Transmission Holdings, Inc.	378,614

Shares	Description	Value

	Machinery (Continued)
4,616	Federal Signal Corp.	$250,233
25,885	PACCAR, Inc.	1,894,782
5,976	Westinghouse Air Brake Technologies Corp.	603,934
		3,127,563
	Passenger Airlines – 9.6%
81,604	American Airlines Group, Inc. (a)	1,203,659
50,079	Delta Air Lines, Inc. (a)	1,748,759
36,952	United Airlines Holdings, Inc. (a)	1,635,126
		4,587,544
	Trading Companies & Distributors – 6.6%
3,881	Herc Holdings, Inc.	442,046
16,897	Triton International Ltd.	1,068,228
4,098	United Rentals, Inc.	1,621,825
		3,132,099
	Total Investments – 99.9%	47,617,997
	(Cost $50,036,810)
	Net Other Assets and Liabilities – 0.1%	47,311
	Net Assets – 100.0%	$47,665,308

(a)	Non-income producing security.

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks*	$ 47,617,997	$ 47,617,997	$ —	$ —

*	See Portfolio of Investments for industry breakout.

Page 30

See Notes to Financial Statements

Table of Contents

First Trust S-Network Streaming & Gaming ETF (BNGE)

Portfolio of Investments

March 31, 2023

Shares	Description	Value
COMMON STOCKS (a) – 99.5%
	Australia – 2.6%
3,706	Aristocrat Leisure Ltd. (b)	$92,659
25,027	Tabcorp Holdings Ltd. (b)	16,687
		109,346
	Cayman Islands – 19.0%
2,004	Bilibili, Inc., ADR (c) (d)	47,094
1,889	Hello Group, Inc., ADR	17,190
5,077	iQIYI, Inc., ADR (d)	36,961
4,774	JOYY, Inc., ADR	148,853
13,775	Kuaishou Technology (b) (d) (e) (f)	105,921
2,014	NetEase, Inc., ADR	178,118
3,671	Tencent Holdings Ltd. (b)	179,399
10,636	Tencent Music Entertainment Group, ADR (d)	88,066
		801,602
	Greece – 0.5%
1,338	OPAP S.A. (b)	21,460
	Ireland – 4.6%
1,084	Flutter Entertainment PLC (b) (d)	195,599
	Isle Of Man (U.K.) – 1.3%
3,673	Entain PLC (b)	57,042
	Japan – 9.8%
2,861	Nexon Co., Ltd. (b)	68,317
4,090	Nintendo Co., Ltd. (b)	158,862
2,023	Sony Group Corp. (b)	184,262
		411,441
	Luxembourg – 2.7%
837	Spotify Technology S.A. (d)	111,840
	Malta – 0.5%
1,717	Kindred Group PLC, SDR (b)	19,227
	South Korea – 0.5%
302	AfreecaTV Co., Ltd. (b)	19,849
	Sweden – 4.1%
1,132	Evolution AB (b) (e) (f)	151,664
896	Viaplay Group AB (b) (d)	22,905
		174,569
	United States – 53.9%
2,233	Activision Blizzard, Inc.	191,122
2,426	Advanced Micro Devices, Inc. (d)	237,772
893	Bally’s Corp. (d)	17,431
2,431	Draftkings, Inc., Class A (d)	47,064
1,359	Electronic Arts, Inc.	163,692
9,131	fuboTV, Inc. (d)	11,049
1,633	GameStop Corp., Class A (c) (d)	37,592
2,562	iHeartMedia, Inc., Class A (d)	9,992

Shares	Description	Value

	United States (Continued)
5,670	Intel Corp.	$185,239
587	Light & Wonder, Inc. (d)	35,249
2,011	MGM Resorts International	89,329
520	Netflix, Inc. (d)	179,650
1,040	NVIDIA Corp.	288,881
975	Penn Entertainment, Inc. (d)	28,918
2,661	ROBLOX Corp., Class A (d)	119,692
770	Roku, Inc. (d)	50,681
4,512	Rush Street Interactive, Inc. (d)	14,032
981	Take-Two Interactive Software, Inc. (d)	117,033
1,613	Unity Software, Inc. (d)	52,326
1,721	Walt Disney (The) Co. (d)	172,324
13,061	Warner Bros Discovery, Inc. (d)	197,221
1,926	Xperi, Inc.	21,051
		2,267,340
	Total Common Stocks	4,189,315
	(Cost $4,213,648)
WARRANTS (a) – 0.0%
	Australia – 0.0%
339	PointsBet Holdings Ltd., expiring 7/28/24 (b) (d) (g)	0
	(Cost $0)
MONEY MARKET FUNDS – 1.7%
71,857	Goldman Sachs Financial Square Treasury Obligations Fund - Institutional Class - 4.69% (h) (i)	71,857
	(Cost $71,857)
Principal Value	Description	Value
REPURCHASE AGREEMENTS – 0.3%
$11,568	BNP Paribas, 4.74% (h), dated 03/31/23, due 04/03/23 with a maturity value of $11,572. Collateralized by U.S. Treasury Securities, interest rates of 1.50% to 2.125%, due 05/15/2025 to 11/30/2028. The value of the collateral including accrued interest is 11,835. (i)	11,568
	(Cost $11,568)
	Total Investments – 101.5%	4,272,740
	(Cost $4,297,073)
	Net Other Assets and Liabilities – (1.5)%	(63,174)
	Net Assets – 100.0%	$4,209,566

See Notes to Financial Statements

Page 31

Table of Contents

First Trust S-Network Streaming & Gaming ETF (BNGE)

Portfolio of Investments (Continued)

March 31, 2023

(a)	Portfolio securities are categorized based upon their country of incorporation, which can be different from the country categorization of the Fund’s underlying index. For a breakdown of the portfolio securities by sector, please see the Fund Performance Overview.
(b)	This security is fair valued by the Advisor’s Pricing Committee in accordance with procedures approved by the Trust’s Board of Trustees and in accordance with provisions of the Investment Company Act of 1940 and rules thereunder, as amended. At March 31, 2023, securities noted as such are valued at $1,293,853 or 30.7% of net assets. Certain of these securities are fair valued using a factor provided by a third-party pricing service due to the change in value between the foreign markets’ close and the New York Stock Exchange close exceeding a certain threshold. On days when this threshold is not exceeded, these securities are typically valued at the last sale price on the exchange on which they are principally traded.
(c)	All or a portion of this security is on loan (See Note 2E - Securities Lending in the Notes to Financial Statements). The remaining contractual maturity of all of the securities lending transactions is overnight and continuous. The aggregate value of such securities is $79,180 and the total value of the collateral held by the Fund is $83,425.
(d)	Non-income producing security.
(e)	This security may be resold to qualified foreign investors and foreign institutional buyers under Regulation S of the Securities Act of 1933, as amended (the “1933 Act”).
(f)	This security is exempt from registration upon resale under Rule 144A of the 1933 Act and may be resold in transactions exempt from registration, normally to qualified institutional buyers. This security is not restricted on the foreign exchange where it trades freely without any additional registration. As such, it does not require the additional disclosure required of restricted securities.
(g)	Pursuant to procedures adopted by the Trust’s Board of Trustees, this security has been determined to be illiquid by the Advisor.
(h)	Rate shown reflects yield as of March 31, 2023.
(i)	This security serves as collateral for securities on loan.

ADR	American Depositary Receipt
SDR	Swedish Depositary Receipt

Offsetting Assets and Liabilities

Offsetting assets and liabilities requires entities to disclose both gross and net information about instruments and transactions eligible for offset, and to disclose instruments and transactions subject to master netting or similar agreements (see Note 2D – Offsetting on the Statements of Assets and Liabilities in the Notes to Financial Statements).

The Fund’s loaned securities were all subject to an enforceable Securities Lending Agency Agreement. Securities lent in accordance with the Securities Lending Agency Agreement on a gross basis were as follows:

Securities Lending Agency Agreement
Total gross amount presented on the Statements of Assets and Liabilities ⁽¹⁾	$79,180
Non-cash Collateral ⁽²⁾	(79,180)
Net Amount	$—

⁽¹⁾	The amount presented on the Statements of Assets and Liabilities, which is included in “Investments, at value,” is not offset and is shown on a gross basis.
⁽²⁾	At March 31, 2023, the value of the collateral received from each borrower exceeded the value of the related securites loaned. This amount is disclosed on the Portfolio of Investments.

The Fund’s investments in repurchase agreements were all subject to an enforceable Master Repurchase Agreement. Repurchase Agreements on a gross basis were as follows:

Repurchase Agreements
Total gross amount presented on the Statements of Assets and Liabilities ⁽³⁾	$11,568
Non-cash Collateral ⁽⁴⁾	(11,568)
Net Amount	$—

⁽³⁾	The amount is included in “Investments, at value” on the Statements of Assets and Liabilities.
⁽⁴⁾	At March 31, 2023, the value of the collateral received from each seller exceeded the value of the repurchase agreements.

Currency Exposure Diversification	% of Total Investments
United States Dollar	69.7%
Japanese Yen	9.6
Hong Kong Dollar	6.7
British Pound Sterling	5.9
Swedish Krona	4.5
Australian Dollar	2.6
Euro	0.5
South Korean Won	0.5
Total	100.0%

Page 32

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Table of Contents

First Trust S-Network Streaming & Gaming ETF (BNGE)

Portfolio of Investments (Continued)

March 31, 2023

Valuation Inputs

A summary of the inputs used to value the Fund’s investments as of March 31, 2023 is as follows (see Note 2A - Portfolio Valuation in the Notes to Financial Statements):

	Total Value at 3/31/2023	Level 1 Quoted Prices	Level 2 Significant Observable Inputs	Level 3 Significant Unobservable Inputs
Common Stocks:
Cayman Islands	$ 801,602	$ 516,282	$ 285,320	$ —
Luxembourg	111,840	111,840	—	—
United States	2,267,340	2,267,340	—	—
Other Country Categories*	1,008,533	—	1,008,533	—
Warrants*	—**	—	—**	—
Money Market Funds	71,857	71,857	—	—
Repurchase Agreements	11,568	—	11,568	—
Total Investments	$ 4,272,740	$ 2,967,319	$ 1,305,421	$—

*	See Portfolio of Investments for country breakout.
**	Investment is valued at $0.

See Notes to Financial Statements

Page 33

Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Assets and Liabilities

March 31, 2023

	First Trust Nasdaq Bank ETF (FTXO)	First Trust Nasdaq Food & Beverage ETF (FTXG)	First Trust Nasdaq Oil & Gas ETF (FTXN)
ASSETS:
Investments, at value	$ 164,165,066	$ 983,471,940	$ 314,051,561
Cash	76,277	341,165	434,206
Foreign currency	—	—	—
Due from authorized participant	—	—	242,635,773
Receivables:
Fund shares sold	—	4,030,886	1,350,154
Dividends	574,981	1,045,983	445,275
Dividend reclaims	—	—	—
Securities lending income	—	—	—
Investment securities sold	5,252,136	1,336,802	4,011,137
Miscellaneous	—	—	229,350
Total Assets	170,068,460	990,226,776	563,157,456
LIABILITIES:
Payables:
Investment securities purchased	—	4,027,935	1,347,180
Investment advisory fees	94,536	521,643	563,893
Collateral for securities on loan	—	—	—
Fund shares redeemed	5,265,900	1,337,764	246,650,145
Total Liabilities	5,360,436	5,887,342	248,561,218
NET ASSETS	$164,708,024	$984,339,434	$314,596,238
NET ASSETS consist of:
Paid-in capital	$ 344,117,195	$ 1,034,664,153	$ 410,543,839
Par value	77,500	365,500	116,500
Accumulated distributable earnings (loss)	(179,486,671)	(50,690,219)	(96,064,101)
NET ASSETS	$164,708,024	$984,339,434	$314,596,238
NET ASSET VALUE, per share	$21.25	$26.93	$27.00
Number of shares outstanding (unlimited number of shares authorized, par value $0.01 per share)	7,750,002	36,550,002	11,650,002
Investments, at cost	$194,286,325	$968,528,695	$309,207,818
Foreign currency, at cost (proceeds)	$—	$—	$—
Securities on loan, at value	$—	$—	$—

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Table of Contents

First Trust Nasdaq Pharmaceuticals ETF (FTXH)	First Trust S-Network E-Commerce ETF (ISHP)	First Trust Nasdaq Semiconductor ETF (FTXL)	First Trust Nasdaq Transportation ETF (FTXR)	First Trust S-Network Streaming & Gaming ETF (BNGE)

$ 32,598,354	$ 5,284,065	$ 985,796,415	$ 47,617,997	$ 4,272,740
30,351	5,451	2,023,674	28,299	10,757
—	19,111	—	—	—
—	—	—	—	—

—	—	—	—	—
28,901	9,411	53,791	26,858	5,371
286	8,788	—	79	354
—	—	—	18,852	149
—	—	3,232,090	—	8,344
—	—	342,265	—	—
32,657,892	5,326,826	991,448,235	47,692,085	4,297,715


—	—	—	—	2,377
18,189	2,598	112,533	26,777	2,347
—	—	—	—	83,425
—	—	3,239,652	—	—
18,189	2,598	3,352,185	26,777	88,149
$ 32,639,703	$ 5,324,228	$ 988,096,050	$ 47,665,308	$ 4,209,566

$ 37,818,562	$ 11,336,914	$ 968,156,049	$ 111,954,016	$ 4,614,814
12,500	2,000	152,500	17,500	2,000
(5,191,359)	(6,014,686)	19,787,501	(64,306,208)	(407,248)
$ 32,639,703	$ 5,324,228	$ 988,096,050	$ 47,665,308	$ 4,209,566
$26.11	$26.62	$64.79	$27.24	$21.05
1,250,002	200,002	15,250,002	1,750,002	200,002
$32,505,824	$6,245,860	$945,362,146	$50,036,810	$4,297,073
$—	$19,146	$—	$—	$—
$—	$—	$—	$—	$79,180

See Notes to Financial Statements

Page 35

Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Operations

For the Year Ended March 31, 2023

	First Trust Nasdaq Bank ETF (FTXO)	First Trust Nasdaq Food & Beverage ETF (FTXG)	First Trust Nasdaq Oil & Gas ETF (FTXN)
INVESTMENT INCOME:
Dividends	$ 7,917,357	$ 19,320,693	$ 36,677,003
Interest	8,412	26,560	40,458
Securities lending income (net of fees)	—	—	—
Foreign withholding tax	(52,336)	—	—
Other	—	—	—
Total investment income	7,873,433	19,347,253	36,717,461
EXPENSES:
Investment advisory fees	1,405,400	5,021,610	7,013,809
Total expenses	1,405,400	5,021,610	7,013,809
NET INVESTMENT INCOME (LOSS)	6,468,033	14,325,643	29,703,652
NET REALIZED AND UNREALIZED GAIN (LOSS):
Net realized gain (loss) on:
Investments	(69,162,767)	(70,568,399)	(128,492,612)
In-kind redemptions	267,718	14,210,368	213,604,191
Foreign currency transactions	—	—	—
Net realized gain (loss)	(68,895,049)	(56,358,031)	85,111,579
Net change in unrealized appreciation (depreciation) on:
Investments	(24,928,953)	14,148,675	(160,545,326)
Foreign currency translation	—	—	—
Net change in unrealized appreciation (depreciation)	(24,928,953)	14,148,675	(160,545,326)
NET REALIZED AND UNREALIZED GAIN (LOSS)	(93,824,002)	(42,209,356)	(75,433,747)
NET INCREASE (DECREASE) IN NET ASSETS RESULTING FROM OPERATIONS	$(87,355,969)	$(27,883,713)	$(45,730,095)

Page 36

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Table of Contents

First Trust Nasdaq Pharmaceuticals ETF (FTXH)	First Trust S-Network E-Commerce ETF (ISHP)	First Trust Nasdaq Semiconductor ETF (FTXL)	First Trust Nasdaq Transportation ETF (FTXR)	First Trust S-Network Streaming & Gaming ETF (BNGE)

$708,752	$65,572	$1,314,577	$1,585,755	$29,871
1,159	720	3,725	2,364	—
—	—	—	319,005	1,106
—	(7,262)	(10,478)	—	(957)
—	154	—	—	6
709,911	59,184	1,307,824	1,907,124	30,026

212,943	43,089	566,621	567,449	24,152
212,943	43,089	566,621	567,449	24,152
496,968	16,095	741,203	1,339,675	5,874


(3,427,408)	(1,821,734)	(15,068,450)	(25,263,128)	(379,392)
4,266,164	(2,213,337)	7,202,562	(24,343,883)	—
—	(222)	—	—	274
838,756	(4,035,293)	(7,865,888)	(49,607,011)	(379,118)

(1,491,531)	886,232	39,410,046	10,350,564	146,392
—	(177)	—	—	(14)
(1,491,531)	886,055	39,410,046	10,350,564	146,378
(652,775)	(3,149,238)	31,544,158	(39,256,447)	(232,740)
$(155,807)	$(3,133,143)	$32,285,361	$(37,916,772)	$(226,866)

See Notes to Financial Statements

Page 37

Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets

	First Trust Nasdaq Bank ETF (FTXO)		First Trust Nasdaq Food & Beverage ETF (FTXG)
	Year Ended 3/31/2023	Year Ended 3/31/2022	Year Ended 3/31/2023	Year Ended 3/31/2022
OPERATIONS:
Net investment income (loss)	$ 6,468,033	$ 5,262,818	$ 14,325,643	$ 109,767
Net realized gain (loss)	(68,895,049)	(1,019,467)	(56,358,031)	(349,011)
Net change in unrealized appreciation (depreciation)	(24,928,953)	(11,467,228)	14,148,675	692,861
Net increase (decrease) in net assets resulting from operations	(87,355,969)	(7,223,877)	(27,883,713)	453,617
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(6,261,407)	(5,155,141)	(13,322,256)	(116,496)
Return of capital	—	—	—	—
Total distributions to shareholders	(6,261,407)	(5,155,141)	(13,322,256)	(116,496)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	38,456,834	231,246,175	1,447,529,232	9,224,482
Cost of shares redeemed	(142,068,023)	(84,224,058)	(432,794,312)	(3,884,145)
Net increase (decrease) in net assets resulting from shareholder transactions	(103,611,189)	147,022,117	1,014,734,920	5,340,337
Total increase (decrease) in net assets	(197,228,565)	134,643,099	973,528,951	5,677,458
NET ASSETS:
Beginning of period	361,936,589	227,293,490	10,810,483	5,133,025
End of period	$164,708,024	$361,936,589	$984,339,434	$10,810,483
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	11,400,002	7,300,002	400,002	200,002
Shares sold	1,400,000	6,750,000	52,250,000	350,000
Shares redeemed	(5,050,000)	(2,650,000)	(16,100,000)	(150,000)
Shares outstanding, end of period	7,750,002	11,400,002	36,550,002	400,002

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First Trust Nasdaq Oil & Gas ETF (FTXN)		First Trust Nasdaq Pharmaceuticals ETF (FTXH)		First Trust S-Network E-Commerce ETF (ISHP)
Year Ended 3/31/2023	Year Ended 3/31/2022	Year Ended 3/31/2023	Year Ended 3/31/2022	Year Ended 3/31/2023	Year Ended 3/31/2022

$ 29,703,652	$ 6,902,387	$ 496,968	$ 185,875	$ 16,095	$ 174,149
85,111,579	170,957,349	838,756	387,327	(4,035,293)	359,766
(160,545,326)	162,037,630	(1,491,531)	444,270	886,055	(2,624,610)
(45,730,095)	339,897,366	(155,807)	1,017,472	(3,133,143)	(2,090,695)

(27,976,256)	(6,320,716)	(500,150)	(176,100)	(39,201)	(143,821)
—	—	—	—	—	—
(27,976,256)	(6,320,716)	(500,150)	(176,100)	(39,201)	(143,821)

1,343,270,023	1,655,064,859	50,373,967	2,582,284	—	36,521,440
(2,102,598,406)	(877,458,299)	(34,389,637)	(5,245,253)	(10,089,830)	(25,144,637)
(759,328,383)	777,606,560	15,984,330	(2,662,969)	(10,089,830)	11,376,803
(833,034,734)	1,111,183,210	15,328,373	(1,821,597)	(13,262,174)	9,142,287

1,147,630,972	36,447,762	17,311,330	19,132,927	18,586,402	9,444,115
$314,596,238	$1,147,630,972	$32,639,703	$17,311,330	$5,324,228	$18,586,402

43,350,002	2,350,002	650,002	750,002	600,002	300,002
50,450,000	76,750,000	1,900,000	100,000	—	1,050,000
(82,150,000)	(35,750,000)	(1,300,000)	(200,000)	(400,000)	(750,000)
11,650,002	43,350,002	1,250,002	650,002	200,002	600,002

See Notes to Financial Statements

Page 39

Table of Contents

First Trust Exchange-Traded Fund VI

Statements of Changes in Net Assets (Continued)

	First Trust Nasdaq Semiconductor ETF (FTXL)		First Trust Nasdaq Transportation ETF (FTXR)
	Year Ended 3/31/2023	Year Ended 3/31/2022	Year Ended 3/31/2023	Year Ended 3/31/2022
OPERATIONS:
Net investment income (loss)	$ 741,203	$ 361,146	$ 1,339,675	$ 10,254,406
Net realized gain (loss)	(7,865,888)	14,839,706	(49,607,011)	18,134,255
Net change in unrealized appreciation (depreciation)	39,410,046	(11,810,521)	10,350,564	(109,717,327)
Net increase (decrease) in net assets resulting from operations	32,285,361	3,390,331	(37,916,772)	(81,328,666)
DISTRIBUTIONS TO SHAREHOLDERS FROM:
Investment operations	(931,111)	(338,211)	(1,511,736)	(10,039,966)
Return of capital	—	—	—	—
Total distributions to shareholders	(931,111)	(338,211)	(1,511,736)	(10,039,966)
SHAREHOLDER TRANSACTIONS:
Proceeds from shares sold	903,564,157	93,443,236	2,951,382	720,128,082
Cost of shares redeemed	(55,273,060)	(72,200,805)	(196,699,292)	(1,419,772,038)
Net increase (decrease) in net assets resulting from shareholder transactions	848,291,097	21,242,431	(193,747,910)	(699,643,956)
Total increase (decrease) in net assets	879,645,347	24,294,551	(233,176,418)	(791,012,588)
NET ASSETS:
Beginning of period	108,450,703	84,156,152	280,841,726	1,071,854,314
End of period	$988,096,050	$108,450,703	$47,665,308	$280,841,726
CHANGES IN SHARES OUTSTANDING:
Shares outstanding, beginning of period	1,550,002	1,300,002	8,700,002	32,600,002
Shares sold	14,600,000	1,300,000	100,000	22,150,000
Shares redeemed	(900,000)	(1,050,000)	(7,050,000)	(46,050,000)
Shares outstanding, end of period	15,250,002	1,550,002	1,750,002	8,700,002

(a)	Inception date is January 25, 2022, which is consistent with the commencement of investment operations and is the date the initial creation units were established.

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First Trust S-Network Streaming & Gaming ETF (BNGE)
Year Ended 3/31/2023		Period Ended 3/31/2022 (a)

$ 5,874		$ 2,572
(379,118)		91
146,378		(170,718)
(226,866)		(168,055)

(11,922)		(405)
(3,048)		—
(14,970)		(405)

959,545		3,660,317
—		—
959,545		3,660,317
717,709		3,491,857

3,491,857		—
$ 4,209,566		$ 3,491,857

150,002		—
50,000		150,002
—		—
200,002		150,002

See Notes to Financial Statements

Page 41

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights

For a share outstanding throughout each period

First Trust Nasdaq Bank ETF (FTXO)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 31.75	$ 31.14	$ 15.64	$ 24.41	$ 29.50
Income from investment operations:
Net investment income (loss)	0.83	0.61	0.59 (a)	0.73	0.84
Net realized and unrealized gain (loss)	(10.54)	0.61 (b)	15.50	(8.77)	(5.14)
Total from investment operations	(9.71)	1.22	16.09	(8.04)	(4.30)
Distributions paid to shareholders from:
Net investment income	(0.79)	(0.61)	(0.59)	(0.73)	(0.79)
Net asset value, end of period	$21.25	$31.75	$31.14	$15.64	$24.41
Total return (c)	(30.94)%	3.89%	105.13%	(33.93)%	(14.49)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 164,708	$ 361,937	$ 227,293	$ 58,658	$ 168,447
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	2.76%	1.91%	2.65%	2.69%	1.83%
Portfolio turnover rate (d)	69%	78%	176%	59%	87%

(a)	Based on average shares outstanding.
(b)	The per share amount does not correlate with the aggregate realized and unrealized gain (loss) due to the timing of the Fund share sales and repurchases in relation to market value fluctuation of the underlying investments.
(c)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(d)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

Page 42

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Food & Beverage ETF (FTXG)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 27.03	$ 25.66	$ 17.28	$ 20.06	$ 19.71
Income from investment operations:
Net investment income (loss)	0.41	0.41	0.32	0.27	0.27
Net realized and unrealized gain (loss)	(0.13)	1.39	8.38	(2.77)	0.33
Total from investment operations	0.28	1.80	8.70	(2.50)	0.60
Distributions paid to shareholders from:
Net investment income	(0.38)	(0.43)	(0.32)	(0.28)	(0.25)
Net asset value, end of period	$26.93	$27.03	$25.66	$17.28	$20.06
Total return (a)	1.10%	7.13%	50.65%	(12.69)%	3.13%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 984,339	$ 10,810	$ 5,133	$ 2,592	$ 2,006
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.71%	1.61%	1.44%	1.58%	1.55%
Portfolio turnover rate (b)	78%	77%	131%	59%	108%

(a)

Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.

(b)

Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

See Notes to Financial Statements

Page 43

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Oil & Gas ETF (FTXN)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 26.47	$ 15.51	$ 8.10	$ 18.91	$ 19.95
Income from investment operations:
Net investment income (loss)	0.69 (a)	0.31	0.22	0.31	0.41
Net realized and unrealized gain (loss)	0.50 (b)	10.96	7.39	(10.79)	(1.06)
Total from investment operations	1.19	11.27	7.61	(10.48)	(0.65)
Distributions paid to shareholders from:
Net investment income	(0.66)	(0.31)	(0.20)	(0.32)	(0.39)
Return of capital	—	—	—	(0.01)	—
Total distributions	(0.66)	(0.31)	(0.20)	(0.33)	(0.39)
Net asset value, end of period	$27.00	$26.47	$15.51	$8.10	$18.91
Total return (c)	4.66%	73.19%	95.16%	(56.26)%	(3.27)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 314,596	$ 1,147,631	$ 36,448	$ 6,885	$ 12,294
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	2.54%	1.87%	2.01%	2.14%	1.69%
Portfolio turnover rate (d)	100%	139%	136%	76%	126%

(a)	Based on average shares outstanding.
(b)	The per share amount does not correlate with the aggregate realized and unrealized gain (loss) due to the timing of the Fund share sales and repurchases in relation to market value fluctuation of the underlying investments.
(c)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(d)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

Page 44

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 26.63	$ 25.51	$ 19.36	$ 21.50	$ 21.14
Income from investment operations:
Net investment income (loss)	0.33	0.27	0.24	0.18	0.13
Net realized and unrealized gain (loss)	(0.50)	1.10	6.14	(2.13)	0.35
Total from investment operations	(0.17)	1.37	6.38	(1.95)	0.48
Distributions paid to shareholders from:
Net investment income	(0.35)	(0.25)	(0.23)	(0.19)	(0.12)
Net asset value, end of period	$26.11	$26.63	$25.51	$19.36	$21.50
Total return (a)	(0.61)%	5.39%	33.00%	(9.13)%	2.30%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 32,640	$ 17,311	$ 19,133	$ 5,810	$ 5,376
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.39%	0.97%	1.07%	0.85%	0.69%
Portfolio turnover rate (b)	76%	77%	83%	42%	107%

(a)

(b)

See Notes to Financial Statements

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First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust S-Network E-Commerce ETF (ISHP)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 30.98	$ 31.48	$ 18.10	$ 22.34	$ 20.86
Income from investment operations:
Net investment income (loss)	0.06 (a)	0.26	0.19	0.27	0.21
Net realized and unrealized gain (loss)	(4.28)	(0.54)	13.39	(4.22)	1.45
Total from investment operations	(4.22)	(0.28)	13.58	(3.95)	1.66
Distributions paid to shareholders from:
Net investment income	(0.14)	(0.22)	(0.20)	(0.29)	(0.18)
Net asset value, end of period	$26.62	$30.98	$31.48	$18.10	$22.34
Total return (b)	(13.57)%	(0.94)%	75.23%	(17.90)%	7.98%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 5,324	$ 18,586	$ 9,444	$ 3,619	$ 8,934
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.23%	0.91%	0.70%	1.11%	1.41%
Portfolio turnover rate (c)	95%	213%	114%	65%	127%

(a)	Based on average shares outstanding.
(b)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(c)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

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Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Semiconductor ETF (FTXL)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 69.97	$ 64.74	$ 33.00	$ 31.83	$ 32.58
Income from investment operations:
Net investment income (loss)	0.46	0.27	0.23	0.38	0.25
Net realized and unrealized gain (loss)	(5.14) (a)	5.22	31.75	1.18	(0.79)
Total from investment operations	(4.68)	5.49	31.98	1.56	(0.54)
Distributions paid to shareholders from:
Net investment income	(0.50)	(0.26)	(0.24)	(0.39)	(0.21)
Net asset value, end of period	$64.79	$69.97	$64.74	$33.00	$31.83
Total return (b)	(6.54)%	8.46%	97.11%	4.82%	(1.62)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 988,096	$ 108,451	$ 84,156	$ 31,353	$ 30,242
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	0.78%	0.40%	0.45%	1.00%	0.78%
Portfolio turnover rate (c)	46%	58%	113%	64%	94%

(a)	The per share amount does not correlate with the aggregate realized and unrealized gain (loss) due to the timing of the Fund share sales and repurchases in relation to market value fluctuation of the underlying investments.
(b)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(c)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

See Notes to Financial Statements

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First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust Nasdaq Transportation ETF (FTXR)

	Year Ended March 31,
	2023	2022	2021	2020	2019
Net asset value, beginning of period	$ 32.28	$ 32.88	$ 15.11	$ 23.33	$ 24.93
Income from investment operations:
Net investment income (loss)	0.56	0.45	0.04	0.30	0.35
Net realized and unrealized gain (loss)	(5.04)	(0.62)	17.79	(8.22)	(1.62)
Total from investment operations	(4.48)	(0.17)	17.83	(7.92)	(1.27)
Distributions paid to shareholders from:
Net investment income	(0.56)	(0.43)	(0.06)	(0.30)	(0.33)
Net asset value, end of period	$27.24	$32.28	$32.88	$15.11	$23.33
Total return (a)	(13.76)%	(0.53)%	118.10%	(34.35)%	(5.11)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 47,665	$ 280,842	$ 1,071,854	$ 1,511	$ 2,333
Ratio of total expenses to average net assets	0.60%	0.60%	0.60%	0.60%	0.60%
Ratio of net investment income (loss) to average net assets	1.42%	0.92%	0.10%	1.04%	1.38%
Portfolio turnover rate (b)	71%	43%	129%	89%	108%

(a)

(b)

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See Notes to Financial Statements

Table of Contents

First Trust Exchange-Traded Fund VI

Financial Highlights (Continued)

For a share outstanding throughout each period

First Trust S-Network Streaming & Gaming ETF (BNGE)

	Year Ended 3/31/2023	Period Ended 3/31/2022 (a)
Net asset value, beginning of period	$ 23.28	$ 24.46
Income from investment operations:
Net investment income (loss)	0.04	0.03
Net realized and unrealized gain (loss)	(2.17)	(1.20)
Total from investment operations	(2.13)	(1.17)
Distributions paid to shareholders from:
Net investment income	(0.08)	(0.00) (b)
Net realized gain	(0.02)	-
Total distributions	(0.10)	(0.00)
Net asset value, end of period	$21.05	$23.28
Total return (c)	(9.08)%	(4.81)%
Ratios to average net assets/supplemental data:
Net assets, end of period (in 000’s)	$ 4,210	$ 3,492
Ratio of total expenses to average net assets	0.70%	0.71% (d)
Ratio of net investment income (loss) to average net assets	0.17%	0.47% (d)
Portfolio turnover rate (e)	42%	0%

(a)	Inception date is January 25, 2022, which is consistent with the commencement of investment operations and is the date the initial creation units were established.
(b)	Amount is less than $0.01.
(c)	Total return is calculated assuming an initial investment made at the net asset value at the beginning of the period, reinvestment of all distributions at net asset value during the period, and redemption at net asset value on the last day of the period. The returns presented do not reflect the deduction of taxes that a shareholder would pay on Fund distributions or the redemption or sale of Fund shares. Total return is calculated for the time period presented and is not annualized for periods of less than a year.
(d)	Annualized.
(e)	Portfolio turnover is calculated for the time period presented and is not annualized for periods of less than a year and does not include securities received or delivered from processing creations or redemptions and in-kind transactions.

See Notes to Financial Statements

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Notes to Financial Statements

First Trust Exchange-Traded Fund VI

March 31, 2023

1. Organization

First Trust Exchange-Traded Fund VI (the “Trust”) is an open-end management investment company organized as a Massachusetts business trust on June 4, 2012, and is registered with the Securities and Exchange Commission under the Investment Company Act of 1940, as amended (the “1940 Act”).

The Trust currently consists of thirty-three exchange-traded funds that are offering shares. This report covers the eight funds (each a “Fund” and collectively, the “Funds”) listed below, each a non-diversified series of the Trust and listed and traded on The Nasdaq Stock Market LLC (“Nasdaq”) with the exception of BNGE which is listed and traded on The NYSE Arca, Inc.

First Trust Nasdaq Bank ETF - (ticker “FTXO”)

First Trust Nasdaq Food & Beverage ETF - (ticker “FTXG”)

First Trust Nasdaq Oil & Gas ETF - (ticker “FTXN”)

First Trust Nasdaq Pharmaceuticals ETF - (ticker “FTXH”)

First Trust S-Network E-Commerce ETF - (ticker “ISHP”)

First Trust Nasdaq Semiconductor ETF - (ticker “FTXL”)

First Trust Nasdaq Transportation ETF - (ticker “FTXR”)

First Trust S-Network Streaming & Gaming ETF - (ticker “BNGE”)

Each Fund represents a separate series of shares of beneficial interest in the Trust. Unlike conventional mutual funds, each Fund issues and redeems shares on a continuous basis, at net asset value (“NAV”), only in large blocks of shares known as “Creation Units.” The investment objective of each Fund is to seek investment results that correspond generally to the price and yield (before the Fund’s fees and expenses) of the following indices:

Fund	Index
First Trust Nasdaq Bank ETF	Nasdaq US Smart Banks^TM Index
First Trust Nasdaq Food & Beverage ETF	Nasdaq US Smart Food & Beverage^TM Index
First Trust Nasdaq Oil & Gas ETF	Nasdaq US Smart Oil & Gas^TM Index
First Trust Nasdaq Pharmaceuticals ETF	Nasdaq US Smart Pharmaceuticals^TM Index
First Trust S-Network E-Commerce ETF	S-Network Global E-Commerce Index^TM
First Trust Nasdaq Semiconductor ETF	Nasdaq US Smart Semiconductor^TM Index
First Trust Nasdaq Transportation ETF	Nasdaq US Smart Transportation^TM Index
First Trust S-Network Streaming & Gaming ETF	S-Network Streaming & Gaming Index

2. Significant Accounting Policies

The Funds are each considered an investment company and follow accounting and reporting guidance under Financial Accounting Standards Board Accounting Standards Codification Topic 946, “Financial Services-Investment Companies.” The following is a summary of significant accounting policies consistently followed by the Funds in the preparation of the financial statements. The preparation of the financial statements in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) requires management to make estimates and assumptions that affect the reported amounts and disclosures in the financial statements. Actual results could differ from those estimates.

A. Portfolio Valuation

Each Fund’s NAV is determined daily as of the close of regular trading on the New York Stock Exchange (“NYSE”), normally 4:00 p.m. Eastern time, on each day the NYSE is open for trading. If the NYSE closes early on a valuation day, the NAV is determined as of that time. Foreign securities are priced using data reflecting the earlier closing of the principal markets for those securities. Each Fund’s NAV is calculated by dividing the value of all assets of each Fund (including accrued interest and dividends), less all liabilities (including accrued expenses and dividends declared but unpaid), by the total number of shares outstanding.

Each Fund’s investments are valued daily at market value or, in the absence of market value with respect to any portfolio securities, at fair value. Market value prices represent readily available market quotations such as last sale or official closing prices from a national or foreign exchange (i.e., a regulated market) and are primarily obtained from third-party pricing services. Fair value prices represent any prices not considered market value prices and are either obtained from a third-party pricing service or are determined by the Pricing Committee of the Funds’ investment advisor, First Trust Advisors L.P. (“First Trust” or the “Advisor”), in accordance with valuation procedures approved by the Trust’s Board of Trustees, and in accordance with provisions of the 1940 Act and rules thereunder. Investments valued by the Advisor’s Pricing Committee, if any, are footnoted as such in the footnotes to the Portfolio of Investments. Each Fund’s investments are valued as follows:

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First Trust Exchange-Traded Fund VI

March 31, 2023

Common stocks, real estate investment trusts (“REITs”), and other equity securities listed on any national or foreign exchange (excluding Nasdaq and the London Stock Exchange Alternative Investment Market (“AIM”)) are valued at the last sale price on the exchange on which they are principally traded or, for Nasdaq and AIM securities, the official closing price. Securities traded on more than one securities exchange are valued at the last sale price or official closing price, as applicable, at the close of the securities exchange representing the primary exchange for such securities.

Securities trading on foreign exchanges or over-the-counter markets that close prior to the NYSE close may be valued using a systematic fair valuation model provided by a third-party pricing service. If these foreign securities meet certain criteria in relation to the valuation model, their valuation is systematically adjusted to reflect the impact of movement in the U.S. market after the close of the foreign markets.

Shares of open-end funds are valued based on NAV per share.

Securities traded in an over-the-counter market are valued at the mean of their most recent bid and asked price, if available, and otherwise at their last trade price.

Overnight repurchase agreements are valued at amortized cost when it represents the most appropriate reflection of fair market value.

Certain securities may not be able to be priced by pre-established pricing methods. Such securities may be valued by the Advisor’s Pricing Committee at fair value. These securities generally include, but are not limited to, restricted securities (securities which may not be publicly sold without registration under the Securities Act of 1933, as amended) for which a third-party pricing service is unable to provide a market price; securities whose trading has been formally suspended; a security whose market or fair value price is not available from a pre-established pricing source; a security with respect to which an event has occurred that is likely to materially affect the value of the security after the market has closed but before the calculation of a Fund’s NAV or make it difficult or impossible to obtain a reliable market quotation; and a security whose price, as provided by the third-party pricing service, does not reflect the security’s fair value. As a general principle, the current fair value of a security would appear to be the amount which the owner might reasonably expect to receive for the security upon its current sale. When fair value prices are used, generally they will differ from market quotations or official closing prices on the applicable exchanges. A variety of factors may be considered in determining the fair value of such securities, including, but not limited to, the following:

1)	the last sale price on the exchange on which they are principally traded or, for Nasdaq and AIM securities, the official closing price;
2)	the type of security;
3)	the size of the holding;
4)	the initial cost of the security;
5)	transactions in comparable securities;
6)	price quotes from dealers and/or third-party pricing services;
7)	relationships among various securities;
8)	information obtained by contacting the issuer, analysts, or the appropriate stock exchange;
9)	an analysis of the issuer’s financial statements;
10)	the existence of merger proposals or tender offers that might affect the value of the security; and
11)	other relevant factors.

If the securities in question are foreign securities, the following additional information may be considered:

1)	the value of similar foreign securities traded on other foreign markets;
2)	ADR trading of similar securities;
3)	closed-end fund or exchange-traded fund trading of similar securities;
4)	foreign currency exchange activity;
5)	the trading prices of financial products that are tied to baskets of foreign securities;
6)	factors relating to the event that precipitated the pricing problem;
7)	whether the event is likely to recur;
8)	whether the effects of the event are isolated or whether they affect entire markets, countries or regions; and
9)	other relevant factors.

In addition, differences between the prices used to calculate a Fund’s NAV and the prices used by such Fund’s corresponding index could result in a difference between a Fund’s performance and the performance of its underlying index.

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First Trust Exchange-Traded Fund VI

March 31, 2023

Because foreign markets may be open on different days than the days during which investors may transact in the shares of a Fund, the value of the Fund’s securities may change on the days when investors are not able to transact in the shares of the Fund. The value of securities denominated in foreign currencies is converted into U.S. dollars using exchange rates determined daily as of the close of regular trading on the NYSE. Any use of a different rate from the rates used by a relevant index may adversely affect the Fund’s ability to track the index.

The Funds are subject to fair value accounting standards that define fair value, establish the framework for measuring fair value and provide a three-level hierarchy for fair valuation based upon the inputs to the valuation as of the measurement date. The three levels of the fair value hierarchy are as follows:

•	Level 1 – Level 1 inputs are quoted prices in active markets for identical investments. An active market is a market in which transactions for the investment occur with sufficient frequency and volume to provide pricing information on an ongoing basis.
•	Level 2 – Level 2 inputs are observable inputs, either directly or indirectly, and include the following:

o	Quoted prices for similar investments in active markets.
o	Quoted prices for identical or similar investments in markets that are non-active. A non-active market is a market where there are few transactions for the investment, the prices are not current, or price quotations vary substantially either over time or among market makers, or in which little information is released publicly.
o	Inputs other than quoted prices that are observable for the investment (for example, interest rates and yield curves observable at commonly quoted intervals, volatilities, prepayment speeds, loss severities, credit risks, and default rates).
o	Inputs that are derived principally from or corroborated by observable market data by correlation or other means.

•	Level 3 – Level 3 inputs are unobservable inputs. Unobservable inputs may reflect the reporting entity’s own assumptions about the assumptions that market participants would use in pricing the investment.

The inputs or methodologies used for valuing investments are not necessarily an indication of the risk associated with investing in those investments. A summary of the inputs used to value each Fund’s investments as of March 31, 2023, is included with each Fund’s Portfolio of Investments.

B. Securities Transactions and Investment Income

Securities transactions are recorded as of the trade date. Realized gains and losses from securities transactions are recorded on the identified cost basis. Dividend income is recorded on the ex-dividend date except that certain dividends from foreign securities are recorded as soon as the information becomes available after the ex-dividend date. Interest income, if any, is recorded on the accrual basis.

Withholding taxes and tax reclaims on foreign dividends have been provided for in accordance with each Fund’s understanding of the applicable country’s tax rules and rates.

Distributions received from a Fund’s investments in REITs may be comprised of return of capital, capital gains, and income. The actual character of the amounts received during the year are not known until after the REITs’ fiscal year end. A Fund records the character of distributions received from the REITs during the year based on estimates available. The characterization of distributions received by a Fund may be subsequently revised based on information received from the REITs after their tax reporting periods conclude.

C. Foreign Currency

The books and records of the Funds are maintained in U.S. dollars. Foreign currencies, investments and other assets and liabilities are translated into U.S. dollars at the exchange rates prevailing at the end of the period. Purchases and sales of investments and items of income and expense are translated on the respective dates of such transactions. Unrealized gains and losses on assets and liabilities, other than investments in securities, which result from changes in foreign currency exchange rates have been included in “Net change in unrealized appreciation (depreciation) on foreign currency translation” on the Statements of Operations. Unrealized gains and losses on investments in securities which result from changes in foreign exchange rates are included with fluctuations arising from changes in market price and are included in “Net change in unrealized appreciation (depreciation) on investments” on the Statements of Operations. Net realized foreign currency gains and losses include the effect of changes in exchange rates between trade date and settlement date on investment security transactions, foreign currency transactions and interest and dividends received and are included in “Net realized gain (loss) on foreign currency transactions” on the Statements of Operations. The portion of foreign currency gains and losses related to fluctuations in exchange rates between the initial purchase settlement date and subsequent sale trade date is included in “Net realized gain (loss) on investments” on the Statements of Operations.

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First Trust Exchange-Traded Fund VI

March 31, 2023

D. Offsetting on the Statements of Assets and Liabilities

Offsetting assets and liabilities requires entities to disclose both gross and net information about instruments and transactions eligible for offset on the Statements of Assets and Liabilities and disclose instruments and transactions subject to master netting or similar agreements. These disclosure requirements are intended to help investors and other financial statement users better assess the effect or potential effect of offsetting arrangements on a Fund’s financial position. The transactions subject to offsetting disclosures are derivative instruments, repurchase agreements and reverse repurchase agreements, and securities borrowing and securities lending transactions.

This disclosure, if applicable, is included within each Fund’s Portfolio of Investments under the heading “Offsetting Assets and Liabilities.” For financial reporting purposes, the Funds do not offset financial assets and financial liabilities that are subject to master netting arrangements (“MNAs”) or similar agreements on the Statements of Assets and Liabilities. MNAs provide the right, in the event of default (including bankruptcy and insolvency), for the non-defaulting counterparty to liquidate the collateral and calculate the net exposure to the defaulting party or request additional collateral.

E. Securities Lending

The Funds may lend securities representing up to 33 1/3% of the value of their total assets to broker-dealers, banks and other institutions to generate additional income. When a Fund loans its portfolio securities, it will receive, at the inception of each loan, collateral equal to at least 102% (for domestic securities) or 105% (for international securities) of the market value of the loaned securities. The collateral amount is valued at the beginning of each business day and is compared to the market value of the loaned securities from the prior business day to determine if additional collateral is required. If additional collateral is required, a request is sent to the borrower. Securities lending involves the risk that the Fund may lose money because the borrower of the Fund’s loaned securities fails to return the securities in a timely manner or at all. The Fund could also lose money in the event of (i) a decline in the value of the collateral provided for the loaned securities, (ii) a decline in the value of any investments made with cash collateral or (iii) an increase in the value of the loaned securities if the borrower does not increase the collateral accordingly and the borrower fails to return the securities. These events could also trigger adverse tax consequences for the Funds.

Under the Funds’ Securities Lending Agency Agreement, the securities lending agent will generally bear the risk that a borrower may default on its obligation to return loaned securities. Brown Brothers Harriman & Co. (“BBH”) acts as the Funds’ securities lending agent and is responsible for executing the lending of the portfolio securities to creditworthy borrowers. The Funds, however, will be responsible for the risks associated with the investment of cash collateral. A Fund may lose money on its investment of cash collateral, which may affect its ability to repay the collateral to the borrower without the use of other Fund assets. Each Fund that engages in securities lending receives compensation (net of any rebate and securities lending agent fees) for lending its securities. Compensation can be in the form of fees received from the securities lending agent or dividends or interest earned from the investment of cash collateral. The fees received from the securities lending agent are accrued daily. The dividend and interest earned on the securities loaned is accounted for in the same manner as other dividend and interest income. At March 31, 2023, only BNGE had securities in the securities lending program. During the fiscal year ended March 31, 2023, only FTXR and BNGE participated in the securities lending program.

In the event of a default by a borrower with respect to any loan, BBH will exercise any and all remedies provided under the applicable borrower agreement to make the Funds whole. These remedies include purchasing replacement securities by applying the collateral held from the defaulting broker against the purchase cost of the replacement securities. If, despite such efforts by BBH to exercise these remedies, a Fund sustains losses as a result of a borrower’s default, BBH will indemnify the Fund by purchasing replacement securities at its own expense, or paying the Funds an amount equal to the market value of the replacement securities, subject to certain limitations which are set forth in detail in the Securities Lending Agency Agreement between the Trust on behalf of the Funds and BBH.

F. Repurchase Agreements

Repurchase agreements involve the purchase of securities subject to the seller’s agreement to repurchase the securities at a mutually agreed upon date and price, under the terms of a Master Repurchase Agreement (“MRA”). During the term of a repurchase agreement, the value of the underlying securities held as collateral on behalf of a Fund, including accrued interest, is required to exceed the value of the repurchase agreement, including accrued interest. The underlying securities for all repurchase agreements are held at the Funds’ custodian or designated sub-custodians under tri-party repurchase agreements.

MRAs govern transactions between a Fund and select counterparties. The MRAs maintain provisions for, among other things, initiation, income payments, events of default, and maintenance of collateral for repurchase agreements.

Repurchase agreements received for lending securities are collateralized by U.S. Treasury securities. The U.S. Treasury securities are held in a joint custody account at BBH on behalf of the Funds participating in the securities lending program. In the event the

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First Trust Exchange-Traded Fund VI

March 31, 2023

counterparty defaults on the repurchase agreement, the U.S. Treasury securities can either be maintained as part of a Fund’s portfolio or sold for cash. A Fund could suffer a loss to the extent that the proceeds from the sale of the underlying collateral held by the Fund are less than the repurchase price and the Fund’s costs associated with the delay and enforcement of the MRA.

While the Funds may invest in repurchase agreements, any repurchase agreements held by the Funds during the fiscal year ended March 31, 2023, were received as collateral for lending securities.

G. Dividends and Distributions to Shareholders

Dividends from net investment income, if any, are declared and paid quarterly by each Fund, or as the Board of Trustees may determine from time to time. Distributions of net realized capital gains earned by each Fund, if any, are distributed at least annually. A Fund may also designate a portion of the amount paid to redeeming shareholders as a distribution for tax purposes.

Distributions from net investment income and realized capital gains are determined in accordance with federal income tax regulations, which may differ from U.S. GAAP. Certain capital accounts in the financial statements are periodically adjusted for permanent differences in order to reflect their tax character. These permanent differences are primarily due to the varying treatment of income and gain/loss on portfolio securities held by the Funds and have no impact on net assets or NAV per share. Temporary differences, which arise from recognizing certain items of income, expense and gain/loss in different periods for financial statement and tax purposes, will reverse at some time in the future.

The tax character of distributions paid by each Fund during the fiscal year ended March 31, 2023, was as follows:

	Distributions paid from Ordinary Income	Distributions paid from Capital Gains	Distributions paid from Return of Capital
First Trust Nasdaq Bank ETF	$ 6,261,407	$ —	$ —
First Trust Nasdaq Food & Beverage ETF	13,322,256	—	—
First Trust Nasdaq Oil & Gas ETF	27,976,256	—	—
First Trust Nasdaq Pharmaceuticals ETF	500,150	—	—
First Trust S-Network E-Commerce ETF	39,201	—	—
First Trust Nasdaq Semiconductor ETF	931,111	—	—
First Trust Nasdaq Transportation ETF	1,511,736	—	—
First Trust S-Network Streaming & Gaming ETF	11,922	—	3,048

The tax character of distributions paid by each Fund during the fiscal period ended March 31, 2022, was as follows:

	Distributions paid from Ordinary Income	Distributions paid from Capital Gains	Distributions paid from Return of Capital
First Trust Nasdaq Bank ETF	$ 5,155,141	$ —	$ —
First Trust Nasdaq Food & Beverage ETF	116,496	—	—
First Trust Nasdaq Oil & Gas ETF	6,320,716	—	—
First Trust Nasdaq Pharmaceuticals ETF	176,100	—	—
First Trust S-Network E-Commerce ETF	143,821	—	—
First Trust Nasdaq Semiconductor ETF	338,211	—	—
First Trust Nasdaq Transportation ETF	10,039,966	—	—
First Trust S-Network Streaming & Gaming ETF	405	—	—

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First Trust Exchange-Traded Fund VI

March 31, 2023

As of March 31, 2023, the components of distributable earnings on a tax basis for each Fund were as follows:

	Undistributed Ordinary Income	Accumulated Capital and Other Gain (Loss)	Net Unrealized Appreciation (Depreciation)
First Trust Nasdaq Bank ETF	$ 536,448	$ (148,409,375)	$ (31,613,744)
First Trust Nasdaq Food & Beverage ETF	1,003,387	(63,514,879)	11,821,273
First Trust Nasdaq Oil & Gas ETF	2,351,864	(93,410,183)	(5,005,782)
First Trust Nasdaq Pharmaceuticals ETF	18,103	(5,088,267)	(121,195)
First Trust S-Network E-Commerce ETF	67,042	(5,050,919)	(1,030,809)
First Trust Nasdaq Semiconductor ETF	—	(18,825,804)	38,613,305
First Trust Nasdaq Transportation ETF	42,379	(61,692,799)	(2,655,788)
First Trust S-Network Streaming & Gaming ETF	—	(287,109)	(120,139)

H. Income Taxes

Each Fund intends to continue to qualify as a regulated investment company by complying with the requirements under Subchapter M of the Internal Revenue Code of 1986, as amended, which includes distributing substantially all of its net investment income and net realized gains to shareholders. Accordingly, no provision has been made for federal and state income taxes. However, due to the timing and amount of distributions, each Fund may be subject to an excise tax of 4% of the amount by which approximately 98% of each Fund’s taxable income exceeds the distributions from such taxable income for the calendar year.

The Funds are subject to accounting standards that establish a minimum threshold for recognizing, and a system for measuring, the benefits of a tax position taken or expected to be taken in a tax return. For all the Funds, with the exception of BNGE, the taxable years ended 2020, 2021, 2022, and 2023 remain open to federal and state audit. For BNGE, the taxable period ended 2022 and year ended 2023 remain open to federal and state audit. As of March 31, 2023, management has evaluated the application of these standards to the Funds and has determined that no provision for income tax is required in the Funds’ financial statements for uncertain tax positions.

The Funds intend to utilize provisions of the federal income tax laws, which allow them to carry a realized capital loss forward indefinitely following the year of the loss and offset such loss against any future realized capital gains. The Funds are subject to certain limitations under U.S. tax rules on the use of capital loss carryforwards and net unrealized built-in losses. These limitations apply when there has been a 50% change in ownership. At March 31, 2023, for federal income tax purposes, the Funds had a capital loss carryforward available that is shown in the following table, to the extent provided by regulations, to offset future capital gains.

	Non-Expiring Capital Loss Carryforward
First Trust Nasdaq Bank ETF	$ 148,409,375
First Trust Nasdaq Food & Beverage ETF	63,514,879
First Trust Nasdaq Oil & Gas ETF	93,410,183
First Trust Nasdaq Pharmaceuticals ETF	5,088,267
First Trust S-Network E-Commerce ETF	5,050,919
First Trust Nasdaq Semiconductor ETF	18,825,804
First Trust Nasdaq Transportation ETF	61,692,799
First Trust S-Network Streaming & Gaming ETF	287,109

In order to present paid-in capital and accumulated distributable earnings (loss) (which consists of accumulated net investment income (loss), accumulated net realized gain (loss) on investments and net unrealized appreciation (depreciation) on investments) on the Statements of Assets and Liabilities that more closely represent their tax character, certain adjustments have been made to paid-in capital, accumulated net investment income (loss) and accumulated net realized gain (loss) on investments. These adjustments are primarily due to the difference between book and tax treatments of income and gains on various investment securities held by the

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Notes to Financial Statements (Continued)

First Trust Exchange-Traded Fund VI

March 31, 2023

Funds and in-kind transactions. The results of operations and net assets were not affected by these adjustments. For the fiscal year ended March 31, 2023, the adjustments for each Fund were as follows:

	Accumulated Net Investment Income (Loss)	Accumulated Net Realized Gain (Loss) on Investments	Paid-in Capital
First Trust Nasdaq Bank ETF	$ —	$ 3,314,741	$ (3,314,741)
First Trust Nasdaq Food & Beverage ETF	—	(9,096,158)	9,096,158
First Trust Nasdaq Oil & Gas ETF	—	(167,616,837)	167,616,837
First Trust Nasdaq Pharmaceuticals ETF	—	(3,873,156)	3,873,156
First Trust S-Network E-Commerce ETF	30,380	2,208,454	(2,238,834)
First Trust Nasdaq Semiconductor ETF	144,387	(5,559,816)	5,415,429
First Trust Nasdaq Transportation ETF	—	25,029,562	(25,029,562)
First Trust S-Network Streaming & Gaming ETF	2,763	(2,763)	—

As of March 31, 2023, the aggregate cost, gross unrealized appreciation, gross unrealized depreciation, and net unrealized appreciation/(depreciation) on investments (including short positions and derivatives, if any) for federal income tax purposes were as follows:

	Tax Cost	Gross Unrealized Appreciation	Gross Unrealized (Depreciation)	Net Unrealized Appreciation (Depreciation)
First Trust Nasdaq Bank ETF	$ 195,778,810	$ 1,960,847	$ (33,574,591)	$ (31,613,744)
First Trust Nasdaq Food & Beverage ETF	971,650,667	46,101,647	(34,280,374)	11,821,273
First Trust Nasdaq Oil & Gas ETF	319,057,343	11,090,775	(16,096,557)	(5,005,782)
First Trust Nasdaq Pharmaceuticals ETF	32,719,549	1,416,176	(1,537,371)	(121,195)
First Trust S-Network E-Commerce ETF	6,314,726	193,839	(1,224,500)	(1,030,661)
First Trust Nasdaq Semiconductor ETF	947,183,110	40,698,040	(2,084,735)	38,613,305
First Trust Nasdaq Transportation ETF	50,273,785	1,491,259	(4,147,047)	(2,655,788)
First Trust S-Network Streaming & Gaming ETF	4,392,872	411,931	(532,063)	(120,132)

I. Expenses

Expenses, other than the investment advisory fee and other excluded expenses, are paid by the Advisor (See Note 3).

First Trust has entered into licensing agreements with Nasdaq, Inc. and VettaFi LLC (each, a “Licensor”), as applicable, for the Funds. The respective license agreement allows for the use by First Trust of each Fund’s respective index and of certain trademarks and trade names of the Licensor. The Funds are sub-licensees to the applicable license agreements.

3. Investment Advisory Fee, Affiliated Transactions and Other Fee Arrangements

First Trust, the investment advisor to the Funds, is a limited partnership with one limited partner, Grace Partners of DuPage L.P., and one general partner, The Charger Corporation. The Charger Corporation is an Illinois corporation controlled by James A. Bowen, Chief Executive Officer of First Trust. First Trust is responsible for the selection and ongoing monitoring of the securities in each Fund’s portfolio, managing the Funds’ business affairs and providing certain administrative services necessary for the management of the Funds.

First Trust is responsible for the expenses of each Fund including the cost of transfer agency, custody, fund administration, licensing fees, legal, audit, and other services, but excluding fee payments under the Investment Management Agreement, interest, taxes, brokerage commissions and other expenses associated with the execution of portfolio transactions, distribution and service fees pursuant to a Rule 12b-1 plan, if any, acquired fund fees and expenses, and extraordinary expenses, which are paid by each respective Fund. First Trust also provides fund reporting services to the Funds for a flat annual fee in the amount of $9,250 per Fund, which is covered under the annual unitary management fee. Effective November 1, 2022, the annual unitary management fee payable by each Fund to First Trust for these services will be reduced at certain levels of each Fund’s net assets (“breakpoints”) and calculated pursuant to the following schedules:

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First Trust Exchange-Traded Fund VI

March 31, 2023

Breakpoints	ISHP	BNGE
Fund net assets up to and including $2.5 billion	0.600%	0.7000%
Fund net assets greater than $2.5 billion up to and including $5 billion	0.585%	0.6825%
Fund net assets greater than $5 billion up to and including $7.5 billion	0.570%	0.6650%
Fund net assets greater than $7.5 billion up to and including $10 billion	0.555%	0.6475%
Fund net assets greater than $10 billion	0.540%	0.6300%

For FTXO, FTXG, FTXN, FTXH, FTXL, and FTXR, the annual unitary management fee payable by each Fund will be calculated pursuant to the schedule below:

Breakpoints
Fund net assets up to and including $2.5 billion	0.600%
Fund net assets greater than $2.5 billion up to and including $5 billion	0.585%
Fund net assets greater than $5 billion up to and including $7.5 billion	0.570%
Fund net assets greater than $7.5 billion up to and including $10 billion	0.555%
Fund net assets greater than $10 billion up to and including $15 billion	0.540%
Fund net assets greater than $15 billion	0.510%

Prior to November 1, 2022, First Trust was paid an annual unitary management fee of 0.60% of each Fund’s average daily net assets, except for BNGE which paid 0.70% of its average daily net assets.

The Trust has multiple service agreements with Brown Brothers Harriman & Co. (“BBH”). Under the service agreements, BBH performs custodial, fund accounting, certain administrative services, and transfer agency services for the Funds. As custodian, BBH is responsible for custody of each Fund’s assets. As fund accountant and administrator, BBH is responsible for maintaining the books and records of each Fund’s securities and cash. As transfer agent, BBH is responsible for maintaining shareholder records for each Fund.

Each Trustee who is not an officer or employee of First Trust, any sub-advisor or any of their affiliates (“Independent Trustees”) is paid a fixed annual retainer that is allocated equally among each fund in the First Trust Fund Complex. Each Independent Trustee is also paid an annual per fund fee that varies based on whether the fund is a closed-end or other actively managed fund, a target outcome fund or an index fund.

Additionally, the Lead Independent Trustee and the Chairs of the Audit Committee, Nominating and Governance Committee and Valuation Committee are paid annual fees to serve in such capacities, with such compensation allocated pro rata among each fund in the First Trust Fund Complex based on net assets. Independent Trustees are reimbursed for travel and out-of-pocket expenses in connection with all meetings. The Lead Independent Trustee and Committee Chairs rotate every three years. The officers and “Interested” Trustee receive no compensation from the Trust for acting in such capacities.

4. Purchases and Sales of Securities

For the fiscal year ended March 31, 2023, the cost of purchases and proceeds from sales of investment securities for each Fund, excluding short-term investments and in-kind transactions, were as follows:

	Purchases	Sales
First Trust Nasdaq Bank ETF	$ 163,288,117	$ 163,386,739
First Trust Nasdaq Food & Beverage ETF	652,278,295	650,499,250
First Trust Nasdaq Oil & Gas ETF	1,113,943,820	1,107,446,926
First Trust Nasdaq Pharmaceuticals ETF	26,135,114	26,091,375
First Trust S-Network E-Commerce ETF	7,006,172	7,353,055
First Trust Nasdaq Semiconductor ETF	70,762,140	70,770,237
First Trust Nasdaq Transportation ETF	71,370,257	71,021,714
First Trust S-Network Streaming & Gaming ETF	1,526,516	1,457,582

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Notes to Financial Statements (Continued)

First Trust Exchange-Traded Fund VI

March 31, 2023

For the fiscal year ended March 31, 2023, the cost of in-kind purchases and proceeds from in-kind sales for each Fund were as follows:

	Purchases	Sales
First Trust Nasdaq Bank ETF	$ 38,350,486	$ 141,397,126
First Trust Nasdaq Food & Beverage ETF	1,445,381,618	432,281,025
First Trust Nasdaq Oil & Gas ETF	1,337,669,413	2,097,484,023
First Trust Nasdaq Pharmaceuticals ETF	50,258,672	34,341,137
First Trust S-Network E-Commerce ETF	—	9,745,589
First Trust Nasdaq Semiconductor ETF	901,172,793	55,163,431
First Trust Nasdaq Transportation ETF	2,948,082	196,275,531
First Trust S-Network Streaming & Gaming ETF	876,675	—

5. Creations, Redemptions and Transaction Fees

Each Fund generally issues and redeems its shares in primary market transactions through a creation and redemption mechanism and does not sell or redeem individual shares. Instead, financial entities known as “Authorized Participants” have contractual arrangements with a Fund or one of the Fund’s service providers to purchase and redeem Fund shares directly with the Fund in large blocks of shares known as “Creation Units.” Prior to the start of trading on every business day, a Fund publishes through the National Securities Clearing Corporation (“NSCC”) the “basket” of securities, cash or other assets that it will accept in exchange for a Creation Unit of the Fund’s shares. An Authorized Participant that wishes to effectuate a creation of a Fund’s shares deposits with the Fund the “basket” of securities, cash or other assets identified by the Fund that day, and then receives the Creation Unit of the Fund’s shares in return for those assets. After purchasing a Creation Unit, the Authorized Participant may continue to hold the Fund’s shares or sell them in the secondary market. The redemption process is the reverse of the purchase process: the Authorized Participant redeems a Creation Unit of a Fund’s shares for a basket of securities, cash or other assets. The combination of the creation and redemption process with secondary market trading in a Fund’s shares and underlying securities provides arbitrage opportunities that are designed to help keep the market price of a Fund’s shares at or close to the NAV per share of the Fund.

Each Fund imposes fees in connection with the purchase of Creation Units. These fees may vary based upon various fact-based circumstances, including, but not limited to, the composition of the securities included in the Creation Unit or the countries in which the transactions are settled. The price for each Creation Unit will equal the daily NAV per share of a Fund times the number of shares in a Creation Unit, plus the fees described above and, if applicable, any operational processing and brokerage costs, transfer fees, stamp taxes and part or all of the spread between the expected bid and offer side of the market related to the securities comprising the creation basket.

Each Fund also imposes fees in connection with the redemption of Creation Units. These fees may vary based upon various fact-based circumstances, including, but not limited to, the composition of the securities included in the Creation Unit or the countries in which the transactions are settled. The price received for each Creation Unit will equal the daily NAV per share of a Fund times the number of shares in a Creation Unit, minus the fees described above and, if applicable, any operational processing and brokerage costs, transfer fees, stamp taxes and part or all of the spread between the expected bid and offer side of the market related to the securities comprising the redemption basket. Investors who use the services of a broker or other such intermediary in addition to an Authorized Participant to effect a redemption of a Creation Unit may also be assessed an amount to cover the cost of such services. The redemption fee charged by a Fund will comply with Rule 22c-2 of the 1940 Act which limits redemption fees to no more than 2% of the value of the shares redeemed.

6. Distribution Plan

The Board of Trustees adopted a Distribution and Service Plan pursuant to Rule 12b-1 under the 1940 Act. In accordance with the Rule 12b-1 plan, each Fund is authorized to pay an amount up to 0.25% of its average daily net assets each year to reimburse First Trust Portfolios L.P. (“FTP”), the distributor of the Funds, for amounts expended to finance activities primarily intended to result in the sale of Creation Units or to provide investor services. FTP may also use this amount to compensate securities dealers or other persons that are Authorized Participants for providing distribution assistance, including broker-dealer and shareholder support and educational and promotional services.

No 12b-1 fees are currently paid by the Funds, and pursuant to a contractual arrangement, no 12b-1 fees will be paid any time before July 31, 2023.

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First Trust Exchange-Traded Fund VI

March 31, 2023

7. Indemnification

The Trust, on behalf of the Funds, has a variety of indemnification obligations under contracts with its service providers. The Trust’s maximum exposure under these arrangements is unknown. However, the Trust has not had prior claims or losses pursuant to these contracts and expects the risk of loss to be remote.

8. Subsequent Events

Management has evaluated the impact of all subsequent events on the Funds through the date the financial statements were issued, and has determined that there was the following subsequent event:

Pursuant to approval by the Trust’s Board of Trustees, The Bank of New York Mellon, 240 Greenwich Street, New York, New York, 10286, replaced Brown Brothers Harriman & Co. as the administrator, custodian, fund accountant and transfer agent for FTXO, FTXG, FTXN, FTXH, FTXL and FTXR on May 8, 2023.

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Report of Independent Registered Public Accounting Firm

To the Shareholders and the Board of Trustees of First Trust Exchange-Traded Fund VI:

Opinion on the Financial Statements and Financial Highlights

We have audited the accompanying statements of assets and liabilities of First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust S-Network E-Commerce ETF, First Trust Nasdaq Semiconductor ETF, First Trust Nasdaq Transportation ETF, and First Trust S-Network Streaming & Gaming ETF (the “Funds”), each a series of First Trust Exchange-Traded Fund VI, including the portfolios of investments, as of March 31, 2023, the related statements of operations for the year then ended, the statements of changes in net assets and the financial highlights for the periods indicated in the table below for the Funds, and the related notes. In our opinion, the financial statements and financial highlights present fairly, in all material respects, the financial position of each of the Funds as of March 31, 2023, and the results of their operations for the year then ended, and the changes in their net assets and the financial highlights for the periods indicated in the table below, in conformity with accounting principles generally accepted in the United States of America.

Individual Funds Included in the Trust	Statements of Changes in Net Assets	Financial Highlights
First Trust Nasdaq Bank ETF	For the years ended March 31, 2023 and 2022	For the years ended March 31, 2023, 2022, 2021, 2020, and 2019
First Trust Nasdaq Food & Beverage ETF
First Trust Nasdaq Oil & Gas ETF
First Trust Nasdaq Pharmaceuticals ETF
First Trust S-Network E-Commerce ETF
First Trust Nasdaq Semiconductor ETF
First Trust Nasdaq Transportation ETF
First Trust S-Network Streaming & Gaming ETF	For the year ended March 31, 2023, and for the period from January 25, 2022 (commencement of operations) through March 31, 2022

Basis for Opinion

These financial statements and financial highlights are the responsibility of the Funds’ management. Our responsibility is to express an opinion on the Funds’ financial statements and financial highlights based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required to be independent with respect to the Funds in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements and financial highlights are free of material misstatement, whether due to error or fraud. The Funds are not required to have, nor were we engaged to perform, an audit of their internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Funds’ internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements and financial highlights, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements and financial highlights. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements and financial highlights. Our procedures included confirmation of securities owned as of March 31, 2023, by correspondence with the custodian and brokers; when replies were not received from brokers, we performed other auditing procedures. We believe that our audits provide a reasonable basis for our opinion.

Chicago, Illinois

May 23, 2023

We have served as the auditor of one or more First Trust investment companies since 2001.

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Additional Information

First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

Proxy Voting Policies and Procedures

A description of the policies and procedures that the Trust uses to determine how to vote proxies and information on how each Fund voted proxies relating to portfolio securities during the most recent 12-month period ended June 30 is available (1) without charge, upon request, by calling (800) 988-5891; (2) on each Fund’s website at www.ftportfolios.com; and (3) on the Securities and Exchange Commission’s (“SEC”) website at www.sec.gov.

Portfolio Holdings

Each Fund files portfolio holdings information for each month in a fiscal quarter within 60 days after the end of the relevant fiscal quarter on Form N-PORT. Portfolio holdings information for the third month of each fiscal quarter will be publicly available on the SEC’s website at www.sec.gov. Each Fund’s complete schedule of portfolio holdings for the second and fourth quarters of each fiscal year is included in the semi-annual and annual reports to shareholders, respectively, and is filed with the SEC on Form N-CSR. The semi-annual and annual report for each Fund is available to investors within 60 days after the period to which it relates. Each Fund’s Forms N-PORT and Forms N-CSR are available on the SEC’s website listed above.

Federal Tax Information

For the taxable year ended March 31, 2023, the following percentages of income dividends paid by the Funds qualify for the dividends received deduction available to corporations:

	Dividends Received Deduction
First Trust Nasdaq Bank ETF	100.00%
First Trust Nasdaq Food & Beverage ETF	100.00%
First Trust Nasdaq Oil & Gas ETF	100.00%
First Trust Nasdaq Pharmaceuticals ETF	100.00%
First Trust S-Network E-Commerce ETF	72.31%
First Trust Nasdaq Semiconductor ETF	100.00%
First Trust Nasdaq Transportation ETF	100.00%
First Trust S-Network Streaming & Gaming ETF	22.61%

For the taxable year ended March 31, 2023, the following percentages of income dividends paid by the Funds are hereby designated as qualified dividend income:

	Qualified Dividend Income
First Trust Nasdaq Bank ETF	100.00%
First Trust Nasdaq Food & Beverage ETF	100.00%
First Trust Nasdaq Oil & Gas ETF	100.00%
First Trust Nasdaq Pharmaceuticals ETF	100.00%
First Trust S-Network E-Commerce ETF	100.00%
First Trust Nasdaq Semiconductor ETF	100.00%
First Trust Nasdaq Transportation ETF	100.00%
First Trust S-Network Streaming & Gaming ETF	50.00%

A portion of the ordinary dividends (including short-term capital gains) that ISHP paid to shareholders during the taxable year ended March 31, 2023, may be eligible for the Qualified Business Income (QBI) Deduction under the Internal Revenue Code of 1986, as amended, Section 199A for the aggregate dividends the Fund received from the underlying Real Estate Investment Trusts (REITs) it invests in.

Risk Considerations

Risks are inherent in all investing. Certain general risks that may be applicable to a Fund are identified below, but not all of the material risks relevant to each Fund are included in this report and not all of the risks below apply to each Fund. The material risks of investing in each Fund are spelled out in its prospectus, statement of additional information and other regulatory filings. Before investing, you should consider each Fund’s investment objective, risks, charges and expenses, and read each

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Additional Information (Continued)

First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

Fund’s prospectus and statement of additional information carefully. You can download each Fund’s prospectus at www.ftportfolios.com or contact First Trust Portfolios L.P. at (800) 621-1675 to request a prospectus, which contains this and other information about each Fund.

Concentration Risk. To the extent that a fund is able to invest a significant percentage of its assets in a single asset class or the securities of issuers within the same country, state, region, industry or sector, an adverse economic, business or political development may affect the value of the fund’s investments more than if the fund were more broadly diversified. A fund that tracks an index will be concentrated to the extent the fund’s corresponding index is concentrated. A concentration makes a fund more susceptible to any single occurrence and may subject the fund to greater market risk than a fund that is more broadly diversified.

Credit Risk. Credit risk is the risk that an issuer of a security will be unable or unwilling to make dividend, interest and/or principal payments when due and the related risk that the value of a security may decline because of concerns about the issuer’s ability to make such payments.

Cyber Security Risk. The funds are susceptible to potential operational risks through breaches in cyber security. A breach in cyber security refers to both intentional and unintentional events that may cause a fund to lose proprietary information, suffer data corruption or lose operational capacity. Such events could cause a fund to incur regulatory penalties, reputational damage, additional compliance costs associated with corrective measures and/or financial loss. In addition, cyber security breaches of a fund’s third-party service providers, such as its administrator, transfer agent, custodian, or sub-advisor, as applicable, or issuers in which the fund invests, can also subject a fund to many of the same risks associated with direct cyber security breaches.

Defined Outcome Funds Risk. To the extent a fund’s investment strategy is designed to deliver returns tied to the price performance of an underlying ETF, an investor may not realize the returns the fund seeks to achieve if that investor does not hold shares for the entire target outcome period. In the event an investor purchases shares after the first day of the target outcome period or sells shares prior to the end of the target outcome period, the buffer that the fund seeks to provide against a decline in the value of the underlying ETF may not be available, the enhanced returns that the fund seeks to provide (if any) may not be available and the investor may not participate in a gain in the value of the underlying ETF up to the cap for the investor’s investment period. Additionally, the fund will not participate in gains of the underlying ETF above the cap and a shareholder may lose their entire investment. If the fund seeks enhanced returns, there are certain time periods when the value of the fund may fall faster than the value of the underlying ETF, and it is very unlikely that, on any given day during which the underlying ETF share price increases in value, the fund’s share price will increase at the same rate as the enhanced returns sought by the fund, which is designed for an entire target outcome period. Trading flexible exchange options involves risks different from, or possibly greater than, the risks associated with investing directly in securities, such as less liquidity and correlation and valuation risks. A fund may experience substantial downside from specific flexible exchange option positions and certain positions may expire worthless.

Derivatives Risk. To the extent a fund uses derivative instruments such as futures contracts, options contracts and swaps, the fund may experience losses because of adverse movements in the price or value of the underlying asset, index or rate, which may be magnified by certain features of the derivative. These risks are heightened when a fund’s portfolio managers use derivatives to enhance the fund’s return or as a substitute for a position or security, rather than solely to hedge (or offset) the risk of a position or security held by the fund.

Equity Securities Risk. To the extent a fund invests in equity securities, the value of the fund’s shares will fluctuate with changes in the value of the equity securities. Equity securities prices fluctuate for several reasons, including changes in investors’ perceptions of the financial condition of an issuer or the general condition of the relevant stock market, such as market volatility, or when political or economic events affecting the issuers occur. In addition, common stock prices may be particularly sensitive to rising interest rates, as the cost of capital rises and borrowing costs increase. Equity securities may decline significantly in price over short or extended periods of time, and such declines may occur in the equity market as a whole, or they may occur in only a particular country, company, industry or sector of the market.

ETF Risk. The shares of an ETF trade like common stock and represent an interest in a portfolio of securities. The risks of owning an ETF generally reflect the risks of owning the underlying securities, although lack of liquidity in an ETF could result in it being more volatile and ETFs have management fees that increase their costs. Shares of an ETF trade on an exchange at market prices rather than net asset value, which may cause the shares to trade at a price greater than net asset value (premium) or less than net asset value (discount). In times of market stress, decisions by market makers to reduce or step away from their role of providing a market for an ETF’s shares, or decisions by an ETF’s authorized participants that they are unable or unwilling to proceed with creation and/or redemption orders of an ETF’s shares, could result in shares of the ETF trading at a discount to net asset value and in greater than normal intraday bid-ask spreads.

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First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

Fixed Income Securities Risk. To the extent a fund invests in fixed income securities, the fund will be subject to credit risk, income risk, interest rate risk, liquidity risk and prepayment risk. Income risk is the risk that income from a fund’s fixed income investments could decline during periods of falling interest rates. Interest rate risk is the risk that the value of a fund’s fixed income securities will decline because of rising interest rates. Liquidity risk is the risk that a security cannot be purchased or sold at the time desired, or cannot be purchased or sold without adversely affecting the price. Prepayment risk is the risk that the securities will be redeemed or prepaid by the issuer, resulting in lower interest payments received by the fund. In addition to these risks, high yield securities, or “junk” bonds, are subject to greater market fluctuations and risk of loss than securities with higher ratings, and the market for high yield securities is generally smaller and less liquid than that for investment grade securities.

Index or Model Constituent Risk. Certain funds may be a constituent of one or more indices or ETF models. As a result, such a fund may be included in one or more index-tracking exchange-traded funds or mutual funds. Being a component security of such a vehicle could greatly affect the trading activity involving a fund, the size of the fund and the market volatility of the fund. Inclusion in an index could increase demand for the fund and removal from an index could result in outsized selling activity in a relatively short period of time. As a result, a fund’s net asset value could be negatively impacted and the fund’s market price may be significantly below its net asset value during certain periods. In addition, index rebalances may potentially result in increased trading activity in a fund’s shares.

Index Provider Risk. To the extent a fund seeks to track an index, it is subject to Index Provider Risk. There is no assurance that the Index Provider will compile the Index accurately, or that the Index will be determined, maintained, constructed, reconstituted, rebalanced, composed, calculated or disseminated accurately. To correct any such error, the Index Provider may carry out an unscheduled rebalance or other modification of the Index constituents or weightings, which may increase the fund’s costs. The Index Provider does not provide any representation or warranty in relation to the quality, accuracy or completeness of data in the Index, and it does not guarantee that the Index will be calculated in accordance with its stated methodology. Losses or costs associated with any Index Provider errors generally will be borne by the fund and its shareholders.

Investment Companies Risk. To the extent a fund invests in the securities of other investment vehicles, the fund will incur additional fees and expenses that would not be present in a direct investment in those investment vehicles. Furthermore, the fund’s investment performance and risks are directly related to the investment performance and risks of the investment vehicles in which the fund invests.

LIBOR Risk. To the extent a fund invests in floating or variable rate obligations that use the London Interbank Offered Rate (“LIBOR”) as a reference interest rate, it is subject to LIBOR Risk. The United Kingdom’s Financial Conduct Authority, which regulates LIBOR has ceased making LIBOR available as a reference rate over a phase-out period that began December 31, 2021. There is no assurance that any alternative reference rate, including the Secured Overnight Financing Rate (“SOFR”) will be similar to or produce the same value or economic equivalence as LIBOR or that instruments using an alternative rate will have the same volume or liquidity. The unavailability or replacement of LIBOR may affect the value, liquidity or return on certain fund investments and may result in costs incurred in connection with closing out positions and entering into new trades. Any potential effects of the transition away from LIBOR on the fund or on certain instruments in which the fund invests can be difficult to ascertain, and they may vary depending on a variety of factors, and they could result in losses to the fund.

Management Risk. To the extent that a fund is actively managed, it is subject to management risk. In managing an actively-managed fund’s investment portfolio, the fund’s portfolio managers will apply investment techniques and risk analyses that may not have the desired result. There can be no guarantee that a fund will meet its investment objective.

Market Risk. Market risk is the risk that a particular security, or shares of a fund in general, may fall in value. Securities held by a fund, as well as shares of a fund itself, are subject to market fluctuations caused by factors such as general economic conditions, political events, regulatory or market developments, changes in interest rates and perceived trends in securities prices. Shares of a fund could decline in value or underperform other investments as a result of the risk of loss associated with these market fluctuations. In addition, local, regional or global events such as war, acts of terrorism, spread of infectious diseases or other public health issues, recessions, or other events could have a significant negative impact on a fund and its investments. Such events may affect certain geographic regions, countries, sectors and industries more significantly than others. In February 2022, Russia invaded Ukraine which has caused and could continue to cause significant market disruptions and volatility within the markets in Russia, Europe, and the United States. The hostilities and sanctions resulting from those hostilities could have a significant impact on certain fund investments as well as fund performance. The COVID-19 global pandemic and the ensuing policies enacted by governments and central banks have caused and may continue to cause significant volatility and uncertainty in global financial markets. While the U.S. has resumed “reasonably” normal business activity, many countries continue to impose lockdown measures. Additionally, there is no guarantee that vaccines will be effective against emerging variants of the disease. These events also adversely affect the prices and liquidity of a fund’s portfolio securities or other instruments and could result in disruptions in the trading markets. Any of such circumstances could have a materially negative impact on the value of a fund’s shares and result in increased market volatility. During any such events, a fund’s shares may trade at increased premiums or discounts to their net asset value and the bid/ask spread on a fund’s shares may widen.

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Additional Information (Continued)

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March 31, 2023 (Unaudited)

Non-U.S. Securities Risk. To the extent a fund invests in non-U.S. securities, it is subject to additional risks not associated with securities of domestic issuers. Non-U.S. securities are subject to higher volatility than securities of domestic issuers due to: possible adverse political, social or economic developments; restrictions on foreign investment or exchange of securities; capital controls; lack of liquidity; currency exchange rates; excessive taxation; government seizure of assets; the imposition of sanctions by foreign governments; different legal or accounting standards; and less government supervision and regulation of exchanges in foreign countries. Investments in non-U.S. securities may involve higher costs than investments in U.S. securities, including higher transaction and custody costs, as well as additional taxes imposed by non-U.S. governments. These risks may be heightened for securities of companies located, or with significant operations, in emerging market countries.

Operational Risk. Each fund is subject to risks arising from various operational factors, including, but not limited to, human error, processing and communication errors, errors of a fund’s service providers, counterparties or other third-parties, failed or inadequate processes and technology or systems failures. Each fund relies on third-parties for a range of services, including custody. Any delay or failure relating to engaging or maintaining such service providers may affect a fund’s ability to meet its investment objective. Although the funds and the funds’ investment advisor seek to reduce these operational risks through controls and procedures, there is no way to completely protect against such risks.

Passive Investment Risk. To the extent a fund seeks to track an index, the fund will invest in the securities included in, or representative of, the index regardless of their investment merit. A fund generally will not attempt to take defensive positions in declining markets.

Preferred Securities Risk. Preferred securities combine some of the characteristics of both common stocks and bonds. Preferred securities are typically subordinated to bonds and other debt securities in a company’s capital structure in terms of priority to corporate income, subjecting them to greater credit risk than those debt securities. Generally, holders of preferred securities have no voting rights with respect to the issuing company unless preferred dividends have been in arrears for a specified number of periods, at which time the preferred security holders may obtain limited rights. In certain circumstances, an issuer of preferred securities may defer payment on the securities and, in some cases, redeem the securities prior to a specified date. Preferred securities may also be substantially less liquid than other securities, including common stock.

Valuation Risk. The valuation of certain securities may carry more risk than that of common stock. Uncertainties in the conditions of the financial markets, unreliable reference data, lack of transparency and inconsistency of valuation models and processes may lead to inaccurate asset pricing. A fund may hold investments in sizes smaller than institutionally sized round lot positions (sometimes referred to as odd lots). However, third-party pricing services generally provide evaluations on the basis of institutionally-sized round lots. If a fund sells certain of its investments in an odd lot transaction, the sale price may be less than the value at which such securities have been held by the fund. Odd lots often trade at lower prices than institutional round lots. There is no assurance that the fund will be able to sell a portfolio security at the price established by the pricing service, which could result in a loss to the fund.

NOT FDIC INSURED

NOT BANK GUARANTEED

MAY LOSE VALUE

Advisory Agreements

Board Considerations Regarding Approval of Amendments to the Investment Management Agreements

The Board of Trustees of First Trust Exchange-Traded Fund VI (the “Trust”), including the Independent Trustees, unanimously approved the amendment (as applicable to a specific Fund, the “Amendment” and collectively, the “Amendments”) of the Investment Management Agreements (as applicable to a specific Fund, the “Agreement” and collectively, the “Agreements”) with First Trust Advisors L.P. (the “Advisor”) on behalf of the following eight series of the Trust (each a “Fund” and collectively, the “Funds”):

First Trust Nasdaq Bank ETF (FTXO)

First Trust Nasdaq Food & Beverage ETF (FTXG)

First Trust Nasdaq Oil & Gas ETF (FTXN)

First Trust Nasdaq Pharmaceuticals ETF (FTXH)

First Trust S-Network E-Commerce ETF (ISHP)

First Trust Nasdaq Semiconductor ETF (FTXL)

First Trust Nasdaq Transportation ETF (FTXR)

First Trust S-Network Streaming & Gaming ETF (BNGE)

The Board approved the Amendment for each Fund at a meeting held on October 24, 2022. As part of the review process, the Board reviewed information and had preliminary discussions with the Advisor regarding the proposed Amendments at meetings held on April 18, 2022, June 12–13, 2022 and September 18–19, 2022. Following those preliminary discussions, the Board requested and

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March 31, 2023 (Unaudited)

received information from the Advisor regarding the proposed Amendments, and that information was considered at an executive session of the Independent Trustees and their counsel held prior to the October 24, 2022 meeting, as well as at the October meeting.

In reviewing the Amendment for each Fund, the Board considered that the purpose of the Amendments is to modify the unitary fee rate for each Fund under the applicable Agreement by introducing a breakpoint schedule pursuant to which the unitary fee rate paid by each Fund to the Advisor will be reduced as assets of such Fund meet certain thresholds. The Board noted the Advisor’s representations that the quality and quantity of the services provided to each Fund by the Advisor under the applicable Agreement will not be reduced or modified as a result of the applicable Amendment, and that the obligations of the Advisor under each Agreement will remain the same in all respects.

The Board noted that it, including the Independent Trustees, last approved the continuation of the applicable Agreement for each Fund other than BNGE for a one-year period ending June 30, 2023 at a meeting held on June 12–13, 2022. The Board noted that in connection with such approval it had determined for each Fund, based upon the information provided, that the terms of the applicable Agreement were fair and reasonable and that the continuation of the applicable Agreement was in the best interests of the Fund in light of the nature, extent and quality of the services provided and such other matters as the Board considered to be relevant in the exercise of its business judgment.

The Board also noted that it, including the Independent Trustees, approved the applicable Agreement for BNGE for an initial two-year period ending May 24, 2023 at a meeting held on April 26, 2021. The Board noted that in connection with such approval it had determined, based upon the information provided, that the terms of the applicable Agreement were fair and reasonable and that the approval of the applicable Agreement was in the best interests of the Fund in light of the nature, extent and quality of the services expected to be provided and such other matters as the Board considered to be relevant in the exercise of its business judgment.

Based on all of the information considered, the Board, including the Independent Trustees, unanimously determined that the terms of the Amendments are fair and reasonable and that the Amendments are in the best interests of each Fund.

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Board of Trustees and Officers

First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

The following tables identify the Trustees and Officers of the Trust. Unless otherwise indicated, the address of all persons is 120 East Liberty Drive, Suite 400, Wheaton, IL 60187.

The Trust’s statement of additional information includes additional information about the Trustees and is available, without charge, upon request, by calling (800) 988-5891.

Name, Year of Birth and Position with the Trust	Term of Office and Year First Elected or Appointed	Principal Occupations During Past 5 Years	Number of Portfolios in the First Trust Fund Complex Overseen by Trustee	Other Trusteeships or Directorships Held by Trustee During Past 5 Years
INDEPENDENT TRUSTEES
Richard E. Erickson, Trustee (1951)	• Indefinite Term • Since Inception	Physician, Edward-Elmhurst Medical Group; Physician and Officer, Wheaton Orthopedics (1990 to 2021)	228	None
Thomas R. Kadlec, Trustee (1957)	• Indefinite Term • Since Inception	Retired; President, ADM Investor Services, Inc. (Futures Commission Merchant) (2010 to July 2022)	228	Director, National Futures Association and ADMIS Singapore Ltd.; Formerly, Director of ADM Investor Services, Inc., ADM Investor Services International, ADMIS Hong Kong Ltd., and Futures Industry Association
Denise M. Keefe, Trustee (1964)	• Indefinite Term • Since 2021	Executive Vice President, Advocate Aurora Health and President, Advocate Aurora Continuing Health Division (Integrated Healthcare System)	228	Director and Board Chair of Advocate Home Health Services, Advocate Home Care Products and Advocate Hospice; Director and Board Chair of Aurora At Home (since 2018); Director of Advocate Physician Partners Accountable Care Organization; Director and Board Chair of RML Long Term Acute Care Hospitals; and Director of Senior Helpers (since 2021)
Robert F. Keith, Trustee (1956)	• Indefinite Term • Since Inception	President, Hibs Enterprises (Financial and Management Consulting)	228	Formerly, Director of Trust Company of Illinois
Niel B. Nielson, Trustee (1954)	• Indefinite Term • Since Inception	Senior Advisor (2018 to Present), Managing Director and Chief Operating Officer (2015 to 2018), Pelita Harapan Educational Foundation (Educational Products and Services)	228	None
INTERESTED TRUSTEE
James A. Bowen⁽¹⁾, Trustee and Chairman of the Board (1955)	• Indefinite Term • Since Inception	Chief Executive Officer, First Trust Advisors L.P. and First Trust Portfolios L.P.; Chairman of the Board of Directors, BondWave LLC (Software Development Company) and Stonebridge Advisors LLC (Investment Advisor)	228	None

⁽¹⁾	Mr. Bowen is deemed an “interested person” of the Trust due to his position as CEO of First Trust Advisors L.P., investment advisor of the Trust.

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Board of Trustees and Officers (Continued)

First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

Name and Year of Birth	Position and Offices with Trust	Term of Office and Length of Service	Principal Occupations During Past 5 Years
OFFICERS⁽²⁾
James M. Dykas (1966)	President and Chief Executive Officer	• Indefinite Term • Since 2016	Managing Director and Chief Financial Officer, First Trust Advisors L.P. and First Trust Portfolios L.P.; Chief Financial Officer, BondWave LLC (Software Development Company) and Stonebridge Advisors LLC (Investment Advisor)
Donald P. Swade (1972)	Treasurer, Chief Financial Officer and Chief Accounting Officer	• Indefinite Term • Since 2016	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.
W. Scott Jardine (1960)	Secretary and Chief Legal Officer	• Indefinite Term • Since Inception	General Counsel, First Trust Advisors L.P. and First Trust Portfolios L.P.; Secretary and General Counsel, BondWave LLC; Secretary, Stonebridge Advisors LLC
Daniel J. Lindquist (1970)	Vice President	• Indefinite Term • Since Inception	Managing Director, First Trust Advisors L.P. and First Trust Portfolios L.P.
Kristi A. Maher (1966)	Chief Compliance Officer and Assistant Secretary	• Indefinite Term • Since Inception	Deputy General Counsel, First Trust Advisors L.P. and First Trust Portfolios L.P.

Roger F. Testin (1966)	Vice President	• Indefinite Term • Since Inception	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.
Stan Ueland (1970)	Vice President	• Indefinite Term • Since Inception	Senior Vice President, First Trust Advisors L.P. and First Trust Portfolios L.P.

⁽²⁾	The term “officer” means the president, vice president, secretary, treasurer, controller or any other officer who performs a policy making function.

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First Trust Exchange-Traded Fund VI

March 31, 2023 (Unaudited)

First Trust values our relationship with you and considers your privacy an important priority in maintaining that relationship. We are committed to protecting the security and confidentiality of your personal information.

Sources of Information

We collect nonpublic personal information about you from the following sources:

•	Information we receive from you and your broker-dealer, investment professional or financial representative through interviews, applications, agreements or other forms;
•	Information about your transactions with us, our affiliates or others;
•	Information we receive from your inquiries by mail, e-mail or telephone; and
•	Information we collect on our website through the use of “cookies.” For example, we may identify the pages on our website that your browser requests or visits.

Information Collected

The type of data we collect may include your name, address, social security number, age, financial status, assets, income, tax information, retirement and estate plan information, transaction history, account balance, payment history, investment objectives, marital status, family relationships and other personal information.

Disclosure of Information

We do not disclose any nonpublic personal information about our customers or former customers to anyone, except as permitted by law. In addition to using this information to verify your identity (as required under law), the permitted uses may also include the disclosure of such information to unaffiliated companies for the following reasons:

•

In order to provide you with products and services and to effect transactions that you request or authorize, we may disclose your personal information as described above to unaffiliated financial service providers and other companies that perform administrative or other services on our behalf, such as transfer agents, custodians and trustees, or that assist us in the distribution of investor materials such as trustees, banks, financial representatives, proxy services, solicitors and printers.

•

We may release information we have about you if you direct us to do so, if we are compelled by law to do so, or in other legally limited circumstances (for example to protect your account from fraud).

In addition, in order to alert you to our other financial products and services, we may share your personal information within First Trust.

Use of Website Analytics

We currently use third party analytics tools, Google Analytics and AddThis, to gather information for purposes of improving First Trust’s website and marketing our products and services to you. These tools employ cookies, which are small pieces of text stored in a file by your web browser and sent to websites that you visit, to collect information, track website usage and viewing trends such as the number of hits, pages visited, videos and PDFs viewed and the length of user sessions in order to evaluate website performance and enhance navigation of the website. We may also collect other anonymous information, which is generally limited to technical and web navigation information such as the IP address of your device, internet browser type and operating system for purposes of analyzing the data to make First Trust’s website better and more useful to our users. The information collected does not include any personal identifiable information such as your name, address, phone number or email address unless you provide that information through the website for us to contact you in order to answer your questions or respond to your requests. To find out how to opt-out of these services click on: Google Analytics and AddThis.

Confidentiality and Security

With regard to our internal security procedures, First Trust restricts access to your nonpublic personal information to those First Trust employees who need to know that information to provide products or services to you. We maintain physical, electronic and procedural safeguards to protect your nonpublic personal information.

Policy Updates and Inquiries

As required by federal law, we will notify you of our privacy policy annually. We reserve the right to modify this policy at any time, however, if we do change it, we will tell you promptly. For questions about our policy, or for additional copies of this notice, please go to www.ftportfolios.com, or contact us at 1-800-621-1675 (First Trust Portfolios) or 1-800-222-6822 (First Trust Advisors).

March 2023

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First Trust Exchange-Traded Fund VI

INVESTMENT ADVISOR

First Trust Advisors L.P.

120 East Liberty Drive, Suite 400

Wheaton, IL 60187

ADMINISTRATOR, CUSTODIAN,
FUND ACCOUNTANT &
TRANSFER AGENT*

Brown Brothers Harriman & Co.

50 Post Office Square

Boston, MA 02110

INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM

Deloitte & Touche LLP

111 S. Wacker Drive

Chicago, IL 60606

LEGAL COUNSEL

Chapman and Cutler LLP

320 South Canal Street

Chicago, IL 60606

* Effective May 8, 2023, the Administrator, Custodian, Fund Accountant & Transfer Agent for First Trust Nasdaq Bank ETF, First Trust Nasdaq Food & Beverage ETF, First Trust Nasdaq Oil & Gas ETF, First Trust Nasdaq Pharmaceuticals ETF, First Trust Nasdaq Semiconductor ETF and First Trust Nasdaq Transportation ETF changed to The Bank of New York Mellon, 240 Greenwich Street, New York, New York, 10286.

Table of Contents

Shareholder Letter	2
Market Overview	3
Fund Performance Overview
First Trust Nasdaq Bank ETF (FTXO)	4
First Trust Nasdaq Food & Beverage ETF (FTXG)	6
First Trust Nasdaq Oil & Gas ETF (FTXN)	8
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	10
First Trust S-Network E-Commerce ETF (ISHP)	12
First Trust Nasdaq Semiconductor ETF (FTXL)	14
First Trust Nasdaq Transportation ETF (FTXR)	16
First Trust S-Network Streaming & Gaming ETF (BNGE)	18
Notes to Fund Performance Overview	20
Understanding Your Fund Expenses	21
Portfolio of Investments
First Trust Nasdaq Bank ETF (FTXO)	23
First Trust Nasdaq Food & Beverage ETF (FTXG)	24
First Trust Nasdaq Oil & Gas ETF (FTXN)	25
First Trust Nasdaq Pharmaceuticals ETF (FTXH)	26
First Trust S-Network E-Commerce ETF (ISHP)	27
First Trust Nasdaq Semiconductor ETF (FTXL)	29
First Trust Nasdaq Transportation ETF (FTXR)	30
First Trust S-Network Streaming & Gaming ETF (BNGE)	31
Statements of Assets and Liabilities	34
Statements of Operations	36
Statements of Changes in Net Assets	38
Financial Highlights	42
Notes to Financial Statements	50
Report of Independent Registered Public Accounting Firm	60
Additional Information	61
Board of Trustees and Officers	66
Privacy Policy	68